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文献詳細

雑誌文献

medicina46巻10号

2009年10月発行

文献概要

今月の主題 一般内科診療における呼吸器薬の使い方 肺炎

耐性菌が疑われる市中肺炎への薬の使い方

著者: 伊藤正仁1 柳秀高1

所属機関: 1東海大学医学部総合内科

ページ範囲:P.1577 - P.1581

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●市中肺炎の最大の起因菌である肺炎球菌のペニシリン感受性の定義が変化した結果,ほとんどの肺炎球菌性肺炎をペニシリンで治療することが公式に可能となった.

●髄膜炎におけるペニシリン感受性の定義はほぼ以前と変わりがないことに注意.

●インフルエンザ桿菌にはβラクタマーゼ陰性でもアンピシリン耐性の株(BLNAR)がある.

●緑膿菌のリスクファクターがある患者では重症度,グラム染色などを手掛かりにカバーするかどうかを決める.

参考文献

1)Mandell LA, et al:IDSA/ATS Consensus Guidelines on Management of Community-Acquired Pneumonia in Adults. Clinical Infectious Diseases 44:S27-72, 2007
2)Hakenbeck R, et al:Mosaic genes and mosaic chromosomes:intra-and interspecies genomic variation of Streptococcus pneumonia. Infect Immun 69:2477-2486, 2001
3)Chiba N, et al:Antibiotic susceptibility according to genotype of penicillin-binding protein and macrolide resistance genes, and serotype of Streptococcus pneumoniae isolates from community-acquired pneumonia in children. Journal of Antimicrobial Chemotherapy 56:756-760, 2005
4)Yu V, et al:An International Prospective Study of Pneumococcal Bacteremia:Correlation with In Vitro Resistance, Antibiotics Administered, and Clinical Outcome. Clinical Infectious Diseases 37:230-237, 2003
5)Whitney CG:Increasing prevalence of multidrug-resistant Streptococcus pneumoniae in the United States. NEJM 343:1917, 2000
6)Wenzel RP, et al:Managing Antibiotic Resistance. NEJM 343:1961-1963, 2000
7)IDSA news. Penicillin‘s back. http://www.idsociety.org/newsArticle.aspx?id=11010, accessed on 2009.5.15.
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9)Song JH, et al:Clinical Outcomes of Pneumococcal Pneumonia Caused by Antibiotic-Resistant Strains in Asian Countries:A study by the Asian Network for Surveillance of Resistant Pathogens. Clinical Infectious Diseases 38:1570, 2004
10)Weinstein MP, et al:Rationale for Revised Penicillin Susceptibility Breakpoints versus Streptococcus pneumoniae:Coping with Antimicrobial Susceptibility in an Era of Resistance. Clinical Infectious Diseases 48:1596, 2009
11)Niki Y, et al:The first nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy. Journal of Infection and Chemotherapy 14:279-290, 2008
12)Thornsberry C, et al:Regional trends in antimicrobial resistance among clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the United States:results from the TRUST Surveillance Program, 1999-2000. Clinical Infectious Diseases 34:S4-16, 2002
13)賀来満夫,他:肺炎球菌およびインフルエンザ菌における薬剤耐性の検討.化学療法の領域23:1318-1326,2007
14)Eskola J, et al:A randomized, prospective field trial of a conjugate vaccine in the protection of infants and young children against invasive Haemophilus influenzae type b disease. NEJM 323:1381-1387, 1990
15)Hasegawa K, et al:High prevalence of type b beta-lactamase-non-producing ampicillin-resistant Haemophilus influenzae in meningitis:the situation in Japan where Hib vaccine has not been introduced. J Antimicrob Chemother 57:1077, 2006
16)Garnacho-Montero J, et al:Optimal management therapy for Pseudomonas aeruginosa ventilator-associated pneumonia:an observational, multicenter study comparing monotherapy with combination antibiotic therapy. Crit Care Med 35:1888-1895, 2007

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1189

印刷版ISSN:0025-7699

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