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medicina46巻11号

2009年11月発行

文献概要

今月の主題 脳卒中の征圧をめざして 脳卒中を知る7つの鍵

脳卒中の危険因子

著者: 二宮利治1 清原裕2

所属機関: 1九州大学大学院医学研究院病態機能内科学 2九州大学大学院医学研究院環境医学分野

ページ範囲:P.1743 - P.1746

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●近年,わが国では降圧治療の普及により,脳卒中に及ぼす高血圧の影響が減少した.

●従来,降圧薬治療の対象とならない軽度の血圧上昇も脳卒中のリスクとなる.

●耐糖能異常,高脂血症などの代謝異常が増加し,脳梗塞の危険因子としての重要性が増している.

●多量飲酒,喫煙は脳卒中の危険因子となる.

●最近注目される危険因子として,高感度C反応性蛋白,メタボリック・シンドローム,慢性腎臓病が挙げられる.

参考文献

1)清原 裕・他:脳卒中の疫学, 井村裕夫・他(編):最新内科学大系 66―脳血管障害, pp 3-11, 中山書店, 1996
2)Lewington S, et al:Age-specific relevance of usual blood pressure to vascular mortality;A meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 360:1903-1913, 2002
3)Fujishima M, et al:Diabetes and cardiovascular disease in a prospective population survey in Japan;The Hisayama Study. Diabetes 45(Suppl 3):S14-S16, 1996
4)Woodward M, et al:The effects of diabetes on the risks of major cardiovascular diseases and death in the Asia-Pacific region. Diabetes Care 26:360-366, 2003
5)Imamura T, et al:LDL cholesterol and the development of stroke subtypes and coronary heart disease in a general Japanese population;The Hisayama Study. Stroke 40:382-388, 2009
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7)Amarenco P, Labreuche J:Lipid management in the prevention of stroke;Review and updated meta-analysis of statins for stroke prevention. Lancet Neurol 8:453-463, 2009
8)Tanizaki Y, et al:Incidence and risk factors for subtypes of cerebral infarction in a general population;The Hisayama Study. Stroke 31:2616-2622, 2000
9)Shinton R, Beevers G:Meta-analysis of relation between cigarette smoking and stroke. BMJ 298:789-794, 1989
10)Kiyohara Y, et al:The impact of alcohol and hypertension on stroke incidence in a general Japanese population;The Hisayama Study. Stroke 26:368-372, 1995
11)Reynolds K, et al:Alcohol consumption and risk of stroke;A meta-analysis. JAMA 289:579-588, 2003
12)Wakugawa Y, et al:C-reactive protein and risk of first-ever ischemic and hemorrhagic stroke in a general Japanese population;The Hisayama Study. Stroke 37:27-32, 2006
13)Kuo HK, et al:Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population;Systematic review and meta-analysis. Lancet Neurol 4:371-380, 2005
14)Ninomiya T, et al:Impact of metabolic syndrome on the development of cardiovascular disease in a general Japanese population;The Hisayama Study. Stroke 38:2063-2069, 2007
15)Li W, et al:Association between metabolic syndrome and risk of stroke;A meta-analysis of cohort studies. Cerebrovasc Dis 25:539-547, 2008
16)Ninomiya T, et al:Impact of kidney disease and blood pressure on the development of cardiovascular disease;An overview from the Japan Arteriosclerosis Longitudinal Study. Circulation 118:2694-2701, 2008

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1189

印刷版ISSN:0025-7699

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