文献詳細
今月の主題 Helicobacter pylori―関連疾患と除菌療法のインパクト
特殊なH. pyloriの除菌療法
文献概要
ポイント
★高齢,消化性潰瘍の既往などのあるH. pylori感染者では,NSAIDs・低用量アスピリンの連用に先立ち除菌治療を行うことが望ましい.
★潰瘍の既往が不明なH. pylori感染者についても除菌治療がNSAIDs潰瘍の発症リスクを低減する報告がある.
★潰瘍既往歴のないH. pylori感染者に対しアスピリン連用に先立ち除菌を積極的に行うべき根拠は現時点ではない.
★高齢,消化性潰瘍の既往などのあるH. pylori感染者では,NSAIDs・低用量アスピリンの連用に先立ち除菌治療を行うことが望ましい.
★潰瘍の既往が不明なH. pylori感染者についても除菌治療がNSAIDs潰瘍の発症リスクを低減する報告がある.
★潰瘍既往歴のないH. pylori感染者に対しアスピリン連用に先立ち除菌を積極的に行うべき根拠は現時点ではない.
参考文献
1)Lanas A, et al:A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal antiinflammatory drug use. Am J Gastroenterol 100:1685-1693, 2005
2)Garcia Rodriguez LA, Jick H:Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs. Lancet 343:769-772, 1994
3)Shield MJ, Morant SV:Misoprostol in patients taking non-steroidal anti-inflammatory drugs. Analysis excluded in important events. Bmj 312:846;author reply 847, 1996
4)Leontiadis GI, et al:Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding. Health Technol Assess 11:iii-iv, 1-164, 2007
5)Chan FK, et al:Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs:a randomised trial. Lancet 359:9-13, 2002
6)Hart J, et al:Predictors of gastroduodenal erosions in patients taking low-dose aspirin. Aliment Pharmacol Ther 31:143-149, 2010
7)日本消化器病学会.消化性潰瘍診療ガイドライン.日本消化器病学会,2009
8)Lai KC, et al:Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. N Engl J Med 346:2033-2038, 2002
9)Fischbach W, et al:S3-guideline " Helicobacter pylori and gastroduodenal ulcer disease" of the German society for digestive and metabolic diseases(DGVS)in cooperation with the German society for hygiene and microbiology, society for pediatric gastroenterology and nutrition e. V., German society for rheumatology, AWMF-registration-no. 021/001. Z Gastroenterol 47:1230-1263, 2009
10)Chan FK, et al:Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen. N Engl J Med 344:967-973, 2001
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