medicina48巻5号

2011年05月発行

今月の主題 脂質異常症―動脈硬化症を予防するためのStrategy ガイドラインをめぐって 【脂質異常症をどの程度に管理すべきと考えるか】

心疾患予防の観点から

著者： 荻田学¹ 宮内克己¹

所属機関： ¹順天堂大学循環器内科

ページ範囲：P.794 - P.798

ポイント

★スタチンによる脂質低下療法の意義は一次予防・二次予防ともに大規模臨床試験の結果から明らかであり，LDLコレステロール（LDL-C）低下に依存して，心血管イベントは減少する．

★予後不良とされる急性冠症候群（acute coronary syndrome：ACS）も積極的脂質低下療法により予後改善効果は実証されており，現在LDL-C達成目標値はより下げる方向にある．

★スタチンによる心血管イベント抑制機序はプラークの安定化が主体と考えられているが，プラーク退縮の関与についても臨床試験結果が報告されている．

参考文献

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