medicina48巻6号

2011年06月発行

今月の主題 睡眠呼吸障害の克服―内科医が知っておきたい病態・症状・関連疾患 睡眠呼吸障害と関連疾患

睡眠呼吸障害と精神疾患

著者： 内村直尚¹

所属機関： ¹久留米大学医学部神経精神医学講座

ページ範囲：P.1014 - P.1018

ポイント

★うつ病や統合失調症などの精神疾患では睡眠時無呼吸症候群を併発しやすい．

★一方，睡眠時無呼吸症候群でもうつ病などの精神疾患を併発しやすい．

★夜間の睡眠障害は全身倦怠感，頭重感および昼間の耐えられない眠気などの身体症状を生じるだけではなく，意欲低下，集中力低下，抑うつ気分などの精神症状も引き起こす．

参考文献

1）Lamphere J, et al:Recovery of alertness after CPAP in apnea. Chest 96:33-38, 1990

2）Walthorn RE, et al:Long-term compliance with nasal continuous positive airway pressure of obstructive sleep apnea. Chest 97:33-38, 1990

3）Cartwright RD, Knights S:Silent partners；The wives of sleep apneic patients. Sleep 10:244-248, 1987

4）Kales A, et al:Severe obstructive sleep apnea-Ⅱ； Associated psychopathology and psychocial consequences. J Chronic Dis 38:427-434, 1985

5）Berry DT, et al:Nocturnal hyoxia and neuropsuchological variables. J Clin Exp Neuropsychol 8:229-238, 1986

6）Derderian SS, et al:Improve after treatment with nasal continuous positive airway pressure. Chest 94:1023-1027, 1988

7）Yang EH, et al:Sleep apnea and quality of life. Sleep 23:535-541, 2000

8）D'Ambrosio C, Bowman T, Mohsenin V:Quality of life in patients with obstructive sleep apnea；Effects of nasal continuous positive airway pressure；A prospective study. Chest 115:123-129, 1999

9）Engleman HM, et al:Randomized placebo controlled trial of daytime function after continuous positive airway pressure（CPAP）therapy for the sleep apnea/hyopopnea syndrome. Thorax 53:341-345, 1998

10）Jenkinson C, et al:Comparison of therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnea；A randomized prospective parallel trial. Lancet 353:2100-2105, 1999

11）Millman RP, et al:Depression as a manifestation of obstructive sleep apnea；Reversal with nasal continuous positive airway pressure. J Clin Psychiatry 5:348-351, 1989

12）Sanchez AI, et al:The effects of continuous positive aire pressure treatment on anxiety and depression levels in apnea patients；Psychiatry Clin. Neurosciences 55:641-646, 2001

13）Watson R, Greenberg G, Bakos L:Sleep apnea and depression. Sleep Res 16:293, 1987

14）Habukawa M, et al:Emotional states and quality of life in patients with obstructive sleep apnea. Sleep and Biological Rhythms 3:99-105, 2005