medicina50巻6号

2013年06月発行

特集 最新の動脈硬化診療―どう診断し，どう治療するか？ 予防と治療の進め方

新しい脂質異常症治療薬―エゼチミブ，EPA・DHA製剤

著者： 山下静也¹

所属機関： ¹大阪大学大学院総合地域医療学・循環器内科学

ページ範囲：P.1046 - P.1055

ポイント

◎エゼチミブは安全性に優れ，スタチンとの併用で強力な効果を発揮する．

◎EPA・DHA製剤は1日1回の投与で効果的にTGを低下させる．

参考文献

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16）GISSI-HF investigators：Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure（the GISSI-HF trial）；A randomised, double-blind, placebo-controlled trial. Lancet 372：1223-1230, 2008

17）Macchia A, et al：Left ventricular systolic dysfunction, total mortality, and sudden death in patients with myocardial infarction treated with n-3 polyunsatuared fatty acids. Eur J Heart Failure 7：904-909, 2005

18）武田薬品：ロトリガインタビューフォーム3版．