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雑誌文献

medicina52巻6号

2015年05月発行

文献概要

特集 感染症診療 それ,ホント? 外来編

腸管出血性大腸菌感染症(血清型O157など)に抗菌薬は危険ってホント?

著者: 大路剛1

所属機関: 1神戸大学大学院医学研究科微生物感染症学講座感染治療学分野

ページ範囲:P.868 - P.871

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●アウトブレイクの経験から,腸管出血性大腸菌(EHEC)感染症において,溶血性尿毒素症症候群(HUS)発症のリスクがないと考えられる抗菌薬は,ホスホマイシンを含め存在しない.
●下血を伴う感染性腸炎疑いの患者では,常にEHECによる感染性腸炎の可能性を考え,抗菌薬投与は慎重であるべきである.

参考文献

1)齊藤 剛,他:腸管出血性大腸菌感染症.IDWR 16:7-9, 2014 http://www.nih.go.jp/niid/ja/ehec/551-idsc/idwr-topic/4841-idwrc-1427.html
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13)腸管出血性大腸菌感染症の診断治療に関する研究班:一次,二次医療機関のための腸管出血性大腸菌(O157等)感染症治療の手引き(改訂版),1997 http://www1.mhlw.go.jp/houdou/0908/h0821-1.html#1-4
14)Bielaszewska M, et al:Effects of antibiotics on Shiga toxin 2 production and bacteriophage induction by epidemic Escherichia coli O104:H4 strain. Antimicrob Agents Chemother 56:3277-3282, 2012
15)Gruppo RA, Rother RP:Eculizumab for congenital atypical hemolytic-uremic syndrome. N Engl J Med 360:544-546, 2009
16)Lapeyraque AL, et al:Eculizumab in severe Shiga-toxin-associated HUS. N Engl J Med 364:2561-2563, 2011
17)Buvens G, et al:Verocytotoxin-producing Escherichia coli O128ab:H2 bacteremia in a 27-year-old male with hemolytic-uremic syndrome. J Clin Microbiol 51:1633-1635, 2013
18)Chiurchiu C, et al:Adult nondiarrhea hemolytic uremic syndrome associated with Shiga toxin Escherichia coli O157:H7 bacteremia and urinary tract infection. Am J Kidney Dis 41:E4, 2003

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1189

印刷版ISSN:0025-7699

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