medicina53巻9号

2016年08月発行

特集 誰も教えてくれなかった—慢性便秘の診かた 慢性便秘へのアプローチ

機能性消化管疾患とのオーバーラップ

著者： 鈴木秀和¹

所属機関： ¹慶應義塾大学医学部医学教育統轄センター

ページ範囲：P.1354 - P.1358

ポイント
●機能性便秘と，機能性ディスペプシア（FD）や胃食道逆流症（GERD）はオーバーラップしやすい．
●オーバーラップ症例の症状は重いことが多い．
●prokineticsは，FDやGERDとオーバーラップした機能性便秘にも奏功する可能性が高い．

参考文献

1）Longstreth GF, et al：Functional bowel disorders. Gastroenterology 130：1480-1491, 2006

2）Lacy BE, et al：Bowel Disorders. Gastroenterology 150：1393-1407, 2016

3）中島滋美：FGIDの基本的知識─定義とオーバーラップ・合併疾患．日内会誌102：40-45, 2013

4）Talley NJ, et al：Overlapping upper and lower gastrointestinal symptoms in irritable bowel syndrome patients with constipation or diarrhea. Am J Gastroenterol 98：2454-2459, 2003

5）Matsuzaki J, et al：Classification of functional dyspepsia based on concomitant bowel symptoms. Neurogastroenterol Motil 24：325-e164, 2012

6）Suzuki H, Hibi T：Overlap syndrome of functional dyspepsia and irritable bowel syndrome；Are both diseases mutually exclusive? J Neurogastroenterol Motil 17：360-365, 2011

7）Riedl A, et al：Somatic comorbidities of irritable bowel syndrome；A systematic analysis. J Psychosom Res 64：573-582, 2008

8）Kaji M, et al：Prevalence of overlaps between GERD, FD and IBS and impact on health-related quality of life. J Gastroenterol Hepatol 25：1151-1156, 2010

9）Ford AC, et al：Systematic review and meta-analysis of the prevalence of irritable bowel syndrome in individuals with dyspepsia. Clin Gastroenterol Hepatol 8：401-409, 2010

10）Locke GR 3rd, et al：Overlap of gastrointestinal symptom complexes in a US community. Neurogastroenterol Motil 17：29-34, 2005

11）Manabe N, et al：Lower functional gastrointestinal disorders；Evidence of abnormal colonic transit in a 287 patient cohort. Neurogastroenterol Motil 22：293-e82, 2010

12）Stanghellini V, et al：Dyspeptic symptoms and gastric emptying in the irritable bowel syndrome. Am J Gastroenterol 97：2738-2743, 2002

13）Shindo T, et al：Comparison of gastric emptying and plasma ghrelin levels in patients with functional dyspepsia and non-erosive reflux disease. Digestion 79：65-72, 2009

14）Corsetti M, et al：Impact of coexisting irritable bowel syndrome on symptoms and pathophysiological mechanisms in functional dyspepsia. Am J Gastroenterol 99：1152-1159, 2004

15）Matsuzaki J, et al：High frequency of overlap between functional dyspepsia and overactive bladder. Neurogastroenterol Motil 24：821-827, 2012

16）Baran M, et al：Gastroesophageal reflux in children with functional constipation. Turk J Gastroenterol 23：634-638, 2012

-associated dyspepsia be categorized as functional dyspepsia? J Gastroenterol Hepatol 26（suppl 3）：42-45, 2011

-associated dyspepsia and functional dyspepsia? J Neurogastroenterol Motil 17：124-130, 2011

gastritis. Gut 64：1353-1367, 2015

gastritis-a novel distinct disease entity. Nature Rev Gastroenterol Hepatol 12：556-557, 2015

21）Fukudo S, et al：Efficacy and safety of oral lubiprostone in constipated patients with or without irritable bowel syndrome；A randomized, placebo-controlled and dose-finding study. Neurogastroenterol Motil 23：544-e205, 2011

22）Ke M, et al：Effect of prucalopride in the treatment of chronic constipation in Asian and non-Asian women；A pooled analysis of 4 randomized, placebo-controlled studies. J Neurogastroenterol Motil 20：458-468, 2014

23）Lacy BE, et al：Linaclotide；A novel therapy for chronic constipation and constipation-predominant irritable bowel syndrome. Gastroenterol Hepatol（N Y）8：653-660, 2012

24）Acosta A, Camilleri M：Elobixibat and its potential role in chronic idiopathic constipation. Therap Adv Gastroenterol 7：167-175, 2014

25）Moayyedi P, et al：Pharmacological interventions for non-ulcer dyspepsia. Cochrane Database Syst Rev：CD001960, 2006

26）Hiyama T, et al：Meta-analysis of the effects of prokinetic agents in patients with functional dyspepsia. J Gastroenterol Hepatol 22：304-310, 2007

27）Matsueda K, et al：A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia. Gut 61：821-828, 2012

28）Seto K, et al：Acotiamide hydrochloride（Z-338）, a novel prokinetic agent, restores delayed gastric emptying and feeding inhibition induced by restraint stress in rats. Neurogastroenterol Motil 20：1051-1059, 2008

29）Matsushita M, et al：Emerging treatments in neurogastroenterology；Acotiamade, a novel treatment option for functional dyspepsia. Neurogastroenterol Motil 28：631-638, 2016

30）Ueda M, et al：Profile of acotiamide in the treatment of functional dyspepsia. Clin Exp Gastroenterol 9：83-88, 2016

31）Suzuki H, Hibi T：Acotiamide（Z-338）as a possible candidate for the treatment of functional dyspepsia. Neurogastroenterol Motil 22：595-599, 2010