文献詳細
文献概要
特集 クリティカル・ケアを極める—一歩進んだ総合内科医を目指して 内科クリティカル・ケア実践編─このパターンを押さえれば8割は対応可能
重症病態に合併する血小板減少のアプローチ
著者: 高岸勝繁1
所属機関: 1京都岡本記念病院総合診療科
ページ範囲:P.1590 - P.1595
文献購入ページに移動Point
◎ICUにおける血小板減少では,敗血症や一過性侵襲による播種性血管内凝固症候群(DIC)として典型的かどうかに注目する.
◎典型的ではない場合は,治療が必要な病態を意識してチェックする.
◎ICUにおける血小板減少では,敗血症や一過性侵襲による播種性血管内凝固症候群(DIC)として典型的かどうかに注目する.
◎典型的ではない場合は,治療が必要な病態を意識してチェックする.
参考文献
1)Hui P, et al:The frequency and clinical significance of thrombocytopenia complicating critical illness;A systematic review. Chest 139:271-278, 2011
2)Thiele T, et al:Thrombocytopenia in the intensive care unit-diagnostic approach and management. Semin Hematol 50:239-250, 2013
3)Zarychanski R, Houston DS:Assessing thrombocytopenia in the intensive care unit;The past, present, and future. Hematology Am Soc Hematol Educ Program 2017:660-666, 2017
4)François B, et al:Thrombocytopenia in the sepsis syndrome;Role of hemophagocytosis and macrophage colony-stimulating factor. Am J Med 103:114-120, 1997
5)Claushuis TA, et al:Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients. Blood 127:3062-3072, 2016
6)Greinacher A, Selleng K:Thrombocytopenia in the intensive care unit patient. Hematology Am Soc Hematol Educ Program 2010:135-143, 2010
7)Kelton JG, et al:Nonheparin anticoagulants for heparin-induced thrombocytopenia. N Engl J Med 368:737-744, 2013
8)Warkentin TE, Heddle NM:Laboratory diagnosis of immune heparin-induced thrombocytopenia. Curr Hematol Rep 2:148-157, 2003
9)Selleng K, et al:Heparin-induced thrombocytopenia in intensive care patients. Crit Care Med 35:1165-1176, 2007
10)Althaus K, et al:Evaluation of automated immunoassays in the diagnosis of heparin induced thrombocytopenia. Thromb Res 131:e85-e90, 2013
11)Ishii E, et al:Nationwide survey of hemophagocytic lymphohistiocytosis in Japan. Int J Hematol 86:58-65, 2007
12)Fardet L, et al:Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Arthritis Rheumatol 66:2613-2620, 2014
13)Valade S, et al:Coagulation disorders and bleeding in critically ill patients with hemophagocytic lymphohistiocytosis. Medicine(Baltimore)94:e1692, 2015
14)Grangé S, et al:The use of ferritin to identify critically ill patients with secondary hemophagocytic lymphohistiocytosis. Crit Care Med 44:e1045-e1053, 2016
15)Demirkol D, et al:Hyperferritinemia in the critically ill child with secondary hemophagocytic lymphohistiocytosis/sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome;What is the treatment? Crit Care 16:R52, 2012
16)George JN, Nester CM:Syndromes of thrombotic microangiopathy. N Engl J Med 371:654-666, 2014
17)George JN:Clinical practice;Thrombotic thrombocytopenic purpura. N Engl J Med 354:1927-1935, 2006
18)Park YA, et al:Platelet count and prothrombin time help distinguish thrombotic thrombocytopenic purpura-hemolytic uremic syndrome from disseminated intravascular coagulation in adults. Am J Clin Pathol 133:460-465, 2010
19)Schapkaitz E, Mezgebe MH:The clinical significance of schistocytes;A prospective evaluation of the International Council for Standardization in Hematology schistocyte guidelines. Turk J Haematol 34:59-63, 2017
20)Huh HJ, et al:Microscopic schistocyte determination according to International Council for Standardization in Hematology recommendations in various diseases. Int J Lab Hematol 35:542-547, 2013
21)Lesesve JF, et al:Schistocytes in disseminated intravascular coagulation. Int J Lab Hematol 36:439-443, 2014
22)Moake JL:Thrombotic microangiopathies. N Engl J Med 347:589-600, 2002
掲載誌情報