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文献詳細

雑誌文献

medicina58巻1号

2021年01月発行

文献概要

特集 エキスパートに学ぶ—最新の循環器治療薬の使い方 知っておくべき10種類の循環器治療薬と治療法

—心不全に対する新規治療薬・3—sGC刺激薬:アデムパス®,vericiguat

著者: 杦山陽一1 田原宣広1 福本義弘1

所属機関: 1久留米大学医学部内科学講座心臓・血管内科部門

ページ範囲:P.32 - P.37

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Question 1
可溶性グアニル酸シクラーゼ(sGC)刺激薬ってどのような薬ですか?

参考文献

1)Ghofrani HA, et al:Riociguat for the treatment of pulmonary arterial hypertension. N Engl J Med 369:330-340, 2013
2)Ghofrani HA, et al:Predictors of long-term outcomes in patients treated with riociguat for pulmonary arterial hypertension;Data from the PATENT-2 open-label, randomised, long-term extension trial. Lancet Respir Med 4:361-371, 2016
3)Ghofrani HA, et al:Riociguat for the treatment of chronic thromboembolic pulmonary hypertension. N Engl J Med 369:319-329, 2013
4)Humbert M, et al:Advances in therapeutic interventions for patients with pulmonary arterial hypertension. Circulation 130:2189-2208, 2014
5)Humbert M, et al:Treatment of pulmonary arterial hypertension. N Engl J Med 351:1425-1436, 2004
6)Hoeper MM, et al:RESPITE;Switching to riociguat in pulmonary arterial hypertension patients with inadequate response to phosphodiesterase-5 inhibitors. Eur Respir J 50:1602425, 2017
7)Califf RM, et al:A randomized controlled trial of epoprostenol therapy for severe congestive heart failure;The Flolan International Randomized Survival Trial(FIRST). Am Heart J 134:44-54, 1997
8)Mylona P, Cleland JG:Update of REACH-1 and MERIT-HF clinical trials in heart failure. Cardio.net Editorial Team. Eur J Heart Fail 1:197-200, 1999
9)Vachiéry JL, et al:Macitentan in pulmonary hypertension due to left ventricular dysfunction. Eur Respir J 51:1701886, 2018
10)Guazzi M, et al:Pulmonary hypertension in heart failure with preserved ejection fraction;A target of phosphodiesterase-5 inhibition in a 1-year study. Circulation 124:164-174, 2011
11)Redfield MM, et al:Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction;A randomized clinical trial. JAMA 309:1268-1277, 2013
12)Ghio S, et al:Left ventricular systolic dysfunction associated with pulmonary hypertension riociguat trial(LEPHT);Rationale and design. Eur J Heart Fail 14:946-953, 2012
13)Bonderman D, et al:Acute hemodynamic effects of riociguat in patients with pulmonary hypertension associated with diastolic heart failure(DILATE-1);A randomized, double-blind, placebo-controlled, single-dose study. Chest 146:1274-1285, 2014
14)Galiè N, et al:The 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension;A practical chronicle of progress. Eur Respir J 46:903-975, 2015
15)Fukuda K, et al:Guidelines for the treatment of pulmonary hypertension(JCS 2017/JPCPHS 2017). Circ J 83:842-945, 2019
16)Armstrong PW, et al:Vericiguat in patients with heart failure and reduced ejection fraction. N Engl J Med 382:1883-1893, 2020
17)Bocchi EA, et al:Inhaled nitric oxide leading to pulmonary edema in stable severe heart failure. Am J Cardiol 74:70-72, 1994

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1189

印刷版ISSN:0025-7699

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