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雑誌文献

medicina58巻1号

2021年01月発行

文献概要

特集 エキスパートに学ぶ—最新の循環器治療薬の使い方 知っておくべき10種類の循環器治療薬と治療法

高トリグリセリド血症に対する新規治療薬:パルモディア®

著者: 吉田尚史1 山下智也2 平田健一1

所属機関: 1神戸大学大学院医学研究科内科学講座循環器内科学分野 2神戸大学医学部附属病院循環器内科

ページ範囲:P.64 - P.68

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Question 1
高トリグリセリド(TG)血症は冠動脈疾患のリスクになりますか?

参考文献

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2)Kajikawa M, et al:Target of triglycerides as residual risk for cardiovascular events in patients with coronary artery disease;Post hoc analysis of the FMD-J Study A. Circ J 83:1064-1071, 2019
3)Otsuka T, et al. Dyslipidemia and the risk of developing hypertension in a working-age male population. Am Heart Assoc 5:e003053, 2016
4)Ye X, et al :Serum triglycerides as a risk factor for cardiovascular diseases in type 2 diabetes mellitus;A systematic review and meta-analysis of prospective studies. Cardiovas Diabetol 18:48, 2019
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6)Bruckert E, et al :Fibrates effect on cardiovascular risk is greater in patients with high triglyceride levels or atherogenic dyslipidemia profile;A systematic review and meta-analysis. Cardiovasc Pharmacol 57:267-272, 2011
7)Marston NA, et al:Association between triglyceride lowering and reduction of cardiovascular risk across multiple lipid-lowering therapeutic classes. Circulation 140:1308-1317, 2019
8)Pradhan AD, et al:Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes(PROMINENT)study. Am Heart J 206:80-93, 2018
9)Fruchart JC:Selective peroxisome proliferator-activated receptorα modulators(SPPARMα);The next generation of peroxisome proliferator-activated receptor α-agonists. Cardiovasc Diabetol 12:82, 2013
F-fluorodeoxyglucose PET-MRI. Diabetes Care 43:1796-1802, 2020
11)Laufs U, et al:Clinical review on triglycerides. Eur Heart J 41:99-109c, 2019
12)Fujihara K, et al:Impact of body mass index and metabolic phenotypes on coronary artery disease according to glucose tolerance status. Diabetes Metab 43:543-546, 2017
13)Tesfaye S, et al:Vascular risk factors and diabetic neuropathy. N Engl J Med 352:341-350, 2005
14)Sacks FM, et al:Association between plasma triglycerides and high-density lipoprotein cholesterol and microvascular kidney disease and retinopathy in type 2 diabetes mellitus. Circulation 129:999-1008, 2014
15)Frick MH, et al:Helsinki Heart Study;Primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med 317:1237-1245, 1987
16)Rubins HB, et al:Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med 341:410-418, 1999
17)Bezafibrate Infarction Prevention(BIP)study:Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease. Circulation 102:21-27, 2000
18)Keech A, et al:Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus(the FIELD study);Randomised controlled trial. Lancet 366:1849-1861, 2005
19)ACCORD Study Group:Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med 362:1563-1574, 2010

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1189

印刷版ISSN:0025-7699

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