medicina58巻1号

2021年01月発行

特集 エキスパートに学ぶ—最新の循環器治療薬の使い方 循環器common diseaseの治療を再考する

—心不全治療薬・3—ACE阻害薬/ARB

著者： 澤村昭典¹

所属機関： ¹一宮市立市民病院循環器内科

ページ範囲：P.86 - P.89

Question 1
ACE阻害薬/ARBそれぞれの薬剤の使い分けはありますか．用量調節は必要ですか？

参考文献

1）Tsutsui H, et al：JCS 2017/JHFS 2017 guideline on diagnosis and treatment of acute and chronic heart failure；Digest version. Circ J 83：2084-2184, 2019

2）McMurray JJ, et al：Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med 371：993-1004, 2014

3）Packer M, et al：Comparative effects of low and high doses of the angiotensin-converting enzyme inhibitor, lisinopril, on morbidity and mortality in chronic heart failure. ATLAS Study Group. Circulation 100：2312-2318, 1999

4）Konstam MA, et al：Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure（HEAAL study）；A randomised, double-blind trial. Lancet 374：1840-1848, 2009

5）Yancy CW, et al：2013 ACCF/AHA guideline for the management of heart failure；A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 62：e147-239, 2013

6）Halliday BP, et al：Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy（TRED-HF）；An open-label, pilot, randomised trial. Lancet 393：61-73, 2019