medicina58巻1号

2021年01月発行

特集 エキスパートに学ぶ—最新の循環器治療薬の使い方 循環器common diseaseの治療を再考する

虚血性心疾患に対する抗血小板薬

著者： 鈴木利章¹ 片岡有¹

所属機関： ¹国立循環器病研究センター心臓血管内科冠疾患科

ページ範囲：P.96 - P.101

Question 1
抗血小板薬の作用機序と薬剤間の使い分けについて教えて下さい．

参考文献

1）Ogawa H, et al：Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes；A randomized controlled trial. JAMA 300：2134-2141, 2008

2）Leon MB, et al：A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. N Engl J Med 339：1665-1671, 1998

3）Ishizaki T, et al：Cytochrome P450 and the metabolism of proton pump inhibitors-emphasis on rabeprazole. Aliment Pharmacol Ther 13 suppl：27-36, 1999

4）Wiviot SD, et al：Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 357：2001-2015, 2007

5）Isshiki T, et al：Prasugrel, a third-generation P2Y12 receptor antagonist, in patients with coronary artery disease undergoing elective percutaneous coronary intervention. Circ J 78：2926-2934, 2014

6）Goto S, et al：Ticagrelor vs. clopidogrel in Japanese, Korean and Taiwanese patients with acute coronary syndrome；Randomized, double-blind, phase Ⅲ PHILO study. Circ J 79：2452-2460, 2015

7）Watanabe H, et al：Effect of 1-month dual antiplatelet therapy followed by clopidogrel vs 12-month dual antiplatelet therapy on cardiovascular and bleeding events in patients receiving PCI；The STOPDAPT-2 randomized clinical trial. JAMA 321：2414-2427, 2019

8）Yasuda S, et al：Antithrombotic therapy for atrial fibrillation with stable coronary disease. N Engl J Med 381：1103-1113, 2019