medicina58巻1号

2021年01月発行

特集 エキスパートに学ぶ—最新の循環器治療薬の使い方 循環器common diseaseの治療を再考する

深部静脈血栓症

著者： 金基泰¹

所属機関： ¹神戸市立医療センター中央市民病院循環器内科

ページ範囲：P.128 - P.132

Question 1
D-dimerが高値でした．抗凝固薬をすぐに始めたほうがよいですか？

参考文献

1）Stein PD, et al：Diagnosis and management of isolated subsegmental pulmonary embolism；Review and assessment of the options. Clin Appl Thromb Hemost 18：20-26, 2012

2）Palareti G, et al：Evolution of untreated calf deep-vein thrombosis in high risk symptomatic outpatients；The blind, prospective CALTHRO study. Thromb Haemost 104：1063-1070, 2010

3）Righini M, et al：Anticoagulant therapy for symptomatic calf deep vein thrombosis（CACTUS）；A randomised, double-blind, placebo-controlled trial. Lancet Haematol 3：e556-e562, 2016

4）Macdonald PS, et al：Short-term natural history of isolated gastrocnemius and soleal vein thrombosis. J Vasc Surg 37：523-527, 2003

5）Hokusai-VTE Investigators, Buller HR, et al：Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med 369：1406-1415, 2013

6）Bauersachs R, et al：EINSTEIN Investigators. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 363：2499-2510, 2010

7）Agnelli G, et al：Oral apixaban for the treatment of acute venous thromboembolism. N Engl J Med 369：799-808, 2013

8）Castellucci LA, et al：Clinical and safety outcomes associated with treatment of acute venous thromboembolism；A systematic review and meta-analysis. JAMA 312：1122-1135, 2014

9）Chai-Adisaksopha C, et al：The impact of bleeding complications in patients receiving target-specific oral anticoagulants；A systematic review and meta-analysis. Blood 124：2450-2458, 2014

10）Lee AY, et al：Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med 349：146-153, 2003

11）Raskob GE, et al, Hokusai VTE Cancer Investigators；Edoxaban for the treatment of cancer-associated venous thromboembolism. N Engl J Med 378：615-624, 2018

12）Young AM, et al：Comparison of an oral factor Xa inhibitor with low molecular weight heparin in patients with cancer with venous thromboembolism；Results of a randomized trial（SELECT-D）. J Clin Oncol 36：2017-2023, 2018

13）Agnelli G, et al：Apixaban for the treatment of venous thromboembolism associated with cancer. N Engl J Med 382：1599-1607, 2020

14）Walker AJ, et al：Incidence of venous thromboembolism in patients with cancer；A cohort study using linked United Kingdom databases. Eur J Cancer 49：1404-1413, 2013

15）Varki A：Trousseau's syndrome；Multiple definitions and multiple mechanisms. Blood 110：1723-1729, 2007

16）van Es N, et al：Screening for occult cancer in patients with unprovoked venous thromboembolism；A systematic review and meta-analysis of individual patient data. Ann Intern Med 167：410-417, 2017

17）Khorana AA, F et al：Frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients. Cancer 110：2339-2346, 2007

18）Khorana AA, et al：Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood 111：4902-4907, 2008