medicina58巻10号

2021年09月発行

特集 腎疾患—エキスパートへの質問で学ぶ診療のキホンと最新情報 水・電解質

皮膚や骨などの血液中以外でのナトリウムの役割や骨粗鬆症・高血圧・感染症との関係などの興味深い最近の知見を教えてください

著者： 木戸口慧¹ 北田研人¹ 西山成¹

所属機関： ¹香川大学医学部薬理学

ページ範囲：P.1616 - P.1619

Point
◎従来，血液中と組織中のナトリウム濃度は平衡化されると考えられてきた．
◎しかしながら，皮膚などにおいて組織局所にナトリウムの制御機構が存在し，血液中と組織中のナトリウム濃度は平衡化されていないことが証明されている．
◎皮膚局所におけるナトリウムの制御機構は，体液保持，高血圧，感染症などと関連している．
◎骨や骨髄局所におけるナトリウム制御機構は，骨芽細胞や破骨細胞の機能を変化させ，骨量に影響を与えることが報告されている．

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