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medicina58巻5号

2021年04月発行

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特集 その考えはもう古い!—最新・感染症診療 診断・治療の最新の考え方 〈治療薬・治療法再考〉

メチシリン耐性黄色ブドウ球菌(MRSA)—どんなときにカバーし,どう治療する?

著者: 冲中敬二12

所属機関: 1国立がん研究センター東病院総合内科 2国立がん研究センター中央病院造血幹細胞移植科

ページ範囲:P.635 - P.640

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◎黄色ブドウ球菌は病原性が強く,播種性感染症のリスクが高い.
◎広域抗菌薬を経験的に開始する際は,終了するための条件を念頭に置く.
◎経験的に開始した場合は,臨床経過や培養検査結果などをもとに,抗MRSA薬の継続の必要性について日々検討する.
◎第一選択はバンコマイシン(VCM)であるが,副作用などの問題がある場合は他剤への変更も考慮する.

参考文献

;Epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev 10:505-520, 1997
among 104 healthy persons during a 19-month period. Epidemiol Infect 115:51-60, 1995
in home care settings;Prevalence, duration, and transmission to household members. Arch Intern Med 169:1372-1378, 2009
. Nat Rev Dis Primers 4:18034, 2018
leads to reduced interactions with endothelial cells and to attenuated virulence in a rabbit model of endocarditis. J Infect Dis 191:1771-1777, 2005
interactions with the endothelium;The role of bacterial “secretable expanded repertoire adhesive molecules”(SERAM)in disturbing host defense systems. Thromb Haemost 94:278-285, 2005
clones increased in Japanese hospitals. J Med Microbiol 67:769-774, 2018
USA300 clone in multiple hospitals in Tokyo, Japan. Clin Microbiol Infect 24:1211 e1-e7, 2018
infection after recent cischarge from an acute-care hospitalization, 2011-2013. Clin Infect Dis 62:45-52, 2016
(MRSA)nares colonization at hospital admission and its effect on subsequent MRSA infection. Clin Infect Dis 39:776-782, 2004
11)Svetitsky S, et al:Comparative efficacy and safety of vancomycin versus teicoplanin;Systematic review and meta-analysis. Antimicrob Agents Chemother 53:4069-4079, 2009
12)Cavalcanti AB, et al:Teicoplanin versus vancomycin for proven or suspected infection. Cochrane Database Syst Rev 6:CD007022, 2010
(MRSA)in a patient with recurrent bacteraemia. J Antimicrob Chemother 57:699-704, 2006
. Clin Infect Dis 38:448-451, 2004
with reduced vancomycin susceptibility. Clin Infect Dis 38:521-528, 2004
16)Lodise TP, et al:Relationship between initial vancomycin concentration-time profile and nephrotoxicity among hospitalized patients. Clin Infect Dis 49:507-514, 2009
infections;A revised consensus guideline and review by the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm 77:835-864, 2020
infections;A systematic review and meta-analysis. Clin Infect Dis 54:755-771, 2012
19)MRSA感染症の治療ガイドライン作成委員会(編):MRSA感染症の治療ガイドライン改訂版2019. http://www.chemotherapy.or.jp/guideline/guideline_mrsa_2019.pdf(2020年12月閲覧)
infections-a systematic review and meta-analysis. Clin Microbiol Infect 24:97-104, 2018
. Clin Infect Dis 42:1652-1653, 2006
(MRSA)blood isolates from 2001-05. J Antimicrob Chemother 60:788-794, 2007
23)Figueroa DA, et al:Safety of high-dose intravenous daptomycin treatment;Three-year cumulative experience in a clinical program. Clin Infect Dis 49:177-180, 2009
bacteremia. Clin Infect Dis 57:1568-1576, 2013
25)Yue J, et al:Linezolid versus vancomycin for skin and soft tissue infections. Cochrane Database Syst Rev 1:CD008056, 2016
26)McCool R, et al:Systematic review and network meta-analysis of tedizolid for the treatment of acute bacterial skin and skin structure infections caused by MRSA. BMC Infect Dis 17:39, 2017
bacteremia;A meta-analysis. Clin Infect Dis 36:53-59, 2003
28)Baddour LM, et al:Infective endocarditis in adults;Diagnosis, antimicrobial therapy, and management of complications;A scientific statement for healthcare professionals from the American Heart Association. Circulation 132:1435-1486, 2015
bacteremia;A pilot multicenter randomized controlled trial. Clin Infect Dis 62:173-180, 2016
bacteremia. Antimicrob Agents Chemother 63:e02483-18, 2019
31)Tong SYC, et al:Effect of vancomycin or daptomycin with vs without an antistaphylococcal beta-lactam on mortality, bacteremia, relapse, or treatment failure in patients with MRSA bacteremia;A randomized clinical trial. JAMA 323:527-537, 2020
32)Talan DA, et al:Trimethoprim-sulfamethoxazole versus placebo for uncomplicated skins abscess. N Engl J Med 374:823-832, 2016
33)Daum RS, et al:A placebo-controlled trial of antibiotics for smaller skin abscesses. N Engl J Med 376:2545-2555, 2017
infections in Taiwan. J Microbiol Immunol Infect 46:147-150, 2013
bacteremia;A systematic review and meta-analysis. J Infect 72:19-28, 2016
bacteremia. Clin Infect Dis 56:527-535, 2013

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1189

印刷版ISSN:0025-7699

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