Neurological Surgery 脳神経外科33巻11号

2005年11月発行

研究

神経外傷における血清S-100B蛋白，NSEの検討

著者： 沢内聡¹ 田屋圭介² 村上成之¹ 石井卓也² 大塚俊宏¹ 加藤直樹¹ 郭樟吾¹ 田中俊英¹ 諸岡暁³ 結城研司³ 浦島充佳⁴ 阿部俊昭²

所属機関： ¹東京慈恵会医科大学附属柏病院脳神経外科 ²東京慈恵会医科大学脳神経外科 ³富士市立中央病院脳神経外科 ⁴東京慈恵会医科大学臨床研究開発室

ページ範囲：P.1073 - P.1080

Ⅰ．はじめに

　現在，神経外傷の病態は画像所見により形態的に分類されているが，脳損傷がどの程度なのかを定量的に評価するのは困難である．近年，神経損傷のマーカーとして，血清S-100B蛋白およびneuron specific enolase（NSE）の有用性が注目されている^{1,3-5,8-13,17)}．S-100B蛋白はグリア細胞，NSEは神経細胞に存在するため，神経特異性が比較的高いとされる^{1,3-5,8-13,17)}．本研究は，頭部外傷後，急性期の血清S-100B蛋白，NSEが神経学的重症度の指標，および転帰の予測因子となり得るか，また，画像上の診断との関連を検討し，病態を解析することを目的とした．

参考文献

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