Neurological Surgery 脳神経外科33巻8号

2005年08月発行

研究

Radiosurgery時代の非機能性下垂体腺腫の治療―術後残存，再発腫瘍に対するガンマナイフ治療の有用性

著者： 岩井謙育¹ 山中一浩¹ 吉岡克宣² 吉村政樹¹ 本田雄二¹ 松阪康弘¹ 小宮山雅樹¹ 安井敏裕¹

所属機関： ¹大阪市立総合医療センター脳神経外科 ²大阪市立総合医療センター内科

ページ範囲：P.777 - P.783

Ⅰ．はじめに

　非機能性下垂体腺腫に対する治療の目的は，視神経の減圧による視機能の改善と長期の腫瘍増大抑制効果である．術後の残存腫瘍の再増大や再発予防のための放射線治療の有効性は報告されている^5,18)．しかし，長期の経過にて，下垂体や周辺組織に対する放射線障害も考慮する必要があり，周辺組織に対する影響のより少ない定位的放射線治療が，従来の放射線治療に比して低侵襲かつ有用と思われる．非機能性下垂体腺腫に対する定位放射線治療の1つであるガンマナイフの治療成績として，高い腫瘍増大抑制効果が報告されている ^21,23)．またガンマナイフ治療を行う立場からは，手術の目的は視神経と腫瘍の距離を十分保てるまで摘出を行うことであるとの意見もあるが¹⁵⁾，手術とガンマナイフをどのように組み合わせるかは，十分検討されていない．われわれは，ガンマナイフの有用性を考えた非機能性下垂体腺腫に対する治療を行ってきたのでその治療成績を報告する．

参考文献

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