Neurological Surgery 脳神経外科34巻12号

2006年12月発行

海外だより

Toronto小児病院におけるてんかん外科の歴史と現況

著者： 大坪宏¹

所属機関： ¹

ページ範囲：P.1217 - P.1223

はじめに

　Toronto小児病院のてんかん外科は古く，1930年代よりMcKenzieらにより半球切除術が行われてきたことに発する．小児病院のてんかん外科は第一世代，半球切除術の時期，第二世代，1974年から側頭葉てんかんを対象にanterior temporal lobectomyをしていた時期，第三世代，1996年から現在まで脳磁図（magnetoencephalography; MEG）と硬膜下電極の登場で新皮質てんかんを対象とした時期，の3期に分けられる．ここでは，これらの小児てんかんに対するToronto小児病院でのてんかん外科手術の変遷を，発表された論文を渉猟しながら紹介する．

参考文献

1）Akai T, Otsubo H, Pang EW, Rutka JT, Chitoku S, Weiss SK, Snead OC Ⅲ：Complex central cortex in pediatric patients with malformations of cortical development. J Child Neurol 17：347-352, 2002

2）Akiyama T, Otsubo H, Ochi A, Ishiguro T, Kadokura G, RamachandranNair R, Weiss SK, Rutka JT, OC Snead Ⅲ：Focal cortical high frequency oscillations trigger epileptic spasms：Confirmation by digital video subdural EEG. Clin Neurophysiol 116：2819-2825, 2005

3）Akiyama T, Otsubo H, Ochi A, Galicia E, Weiss SK, DOnner E, Rutka JT, Snead OC Ⅲ：Topographic movie of ictal high-frequency oscillations on the brain surface using subdural EEG in neocortical epilepsy. Accepted to Epilepsia (in press)

4）Araki T, Otsubo H, Makino Y, Elliott I, Iida K, Ochi A, Weiss SK, Chuang SH, Rutka JT, Snead OC Ⅲ：Efficacy of dexamethasone on cerebral swelling and seizures during subdural grid EEG recording in children. Epilepsia 47：176-180, 2006

5）Boon P, D’Have M, Adam C, Vonck K, Baulac M, Vandekerckhove T, De Reuck J：Dipole modeling in epilepsy surgery candidates. Epilepsia 38：208-218, 1997

6）Chitoku S, Otsubo H, Harada Y, Jay V, Rutka JT, Weiss SK, Abdoll M, Snead OC Ⅲ：Extraoperative cortical stimulation of motor function in children. Pediatr Neurol 24：344-350, 2001

7）Chitoku S, Otsubo H, Harada Y, Jay V, Rutka JT, Weiss SK, Elliott I, Ochi A, Kitayama M, Snead OC Ⅲ：Characteristics of prolonged afterdischarges in children with malformations of cortical development. J Child Neurol 18：247-253, 2003

8）Drake J, Hoffman HJ, Kobayashi J, Hwang P, Becker LE：Surgical management of children with temporal lobe epilepsy and mass lesions. Neurosurgery 21：792-797, 1987

9）Hendrick EB, Hoffman HJ, Hudson AR：Hemispherectomy in children.Clin Neurosurg 16：315-27, 1969

10）Hodaie M, Musharbash A, Otsubo H, Snead OC 3rd, Chitoku S, Ochi A, Holowka S, Hoffman HJ, Rutka JT：Image-guided, frameless stereotactic sectioning of the corpus callosum in children with intractable epilepsy. Pediatr Neurosurg 34：286-294, 2001

11）Hoffman HJ, Hendrick EB, Dennis M, Armstrong D：Hemispherectomy for Sturge-Weber syndrome. Childs Brain 5：233-248, 1979

12）Holowka S, Otsubo H, Iida K, Pang E, Sharma R, Hunjan A, Xiang J, Snead OC Ⅲ, Chuang N, Chuang SH, Rutka JT：Three dimensionally reconstructed magnetic source imaging and neuronavigation in pediatric epilepsy. Technical Note. Neruosurgery 55：E1244-1248, 2004

13）Iida K, Otsubo H, Matsumoto Y, Ochi A, Oishi M, Holowka S, Pang E, Elliott I, Weiss SK, Chuang SH, Snead OC 3rd, Rutka JT：Characterizing magnetic spike sources with magnetoencephalography-guided neuronavigation in pediatric epilepsy surgery. J Neurosurg 102：187-196, 2005

14）Jacobs KM, Gutnick MJ, Prince DA. Hyperexcitability in a model of cortical maldevelopment. Cerebr Cortex 6：511-523, 1996

15）Kuzniecky R, Garcia JH, Faught E, Morawetz RB： Cortical dysplasia in temporal lobe epilepsy：Magnetic resonance imaging correlations. Ann Neurol 29：293-298, 1991

16）Minassian BA, Otsubo H, Weiss S, Elliott I, Rutka JT, Snead OC Ⅲ：Magnetoencephalographic localization in pediatric epilepsy surgery：comparison with invasive intracranial electroencephalography. Ann Neurol 46：627-633, 1999

17）Mohamed I, Otsubo H, Shroff M, Donner E, Drake J, Snead OC Ⅲ：Magnetoencephalography and diffusion tensor imaging in gelastic seizures secondary to a cingulated gyrus lesion. Clin Neurol Neurosurg 2006 Aug (Epub ahead of print)

18）Ochi A, Otsubo H, Chitoku S, Hunjan A, Sharma R, Rutka JT, Chuang SH, Kamijo K, Yamazaki T, Snead OC 3rd：Dipole localization for identification of neuronal generators in independent neighboring interictal EEG spike foci. Epilepsia 42：483-490, 2001

19）Ochi A, Otsubo H, Sharma R, Hunjan A, Rutka JT, Chuang SH, Kamijo K, Yamazaki T, Quint P, Kurelowech L, Sobel DF, Aung MH, Snead OC Ⅲ：Comparison of electroencephalographic dipoles of interictal spikes from prolonged scalp video-electroencephalo graphy and magnetoencephalographic dipoles from short-term recording in children with extratemporal lobe epilepsy. J Child Neurol 16：661-667, 2001

20）Ochi A, Otsubo H, Donner EJ, Elliot I, Iwata R, Funaki T, Akizuki Y, Akiyama T, Imai K, Rutka JT, Snead OC Ⅲ：Dynamic changes of ictal high-frequency oscillations in neocortical epilepsy：Using multiple band frequency analysis. Accepted to Epilepsia (in press)

21）Oishi M, Otsubo H, Suyama Y, Ochi A, Iida K, Weiss SK, Xiang J, Gaetz W, Cheyne D, Chuang SH, Rutka JT, Snead OC Ⅲ：Virtual intracranial interictal epileptiform discharges using synthetic aperture magnetometry. J Neurosurg (1 Suppl Pediatrics) 105：41-49, 2006

22）Oguni H, Olivier A, Andermann, F, Comair J：Anterior callosotomy in the treatment of medically intractable epilepsies：a study of 43 patients with a mean follow-up of 39 months. Ann Neurol 30：357-364, 1991

23）Onal C, Otsubo H, Araki T, Chitoku S, Ochi A, Weiss S, Elliott I, Snead OC Ⅲ, Rutka JT, Logan W：Complications of invasive subdural grid monitoring in children with epilepsy. J Neurosurg 98：1017-1026, 2003

24）Otsubo H, Chuang SH, Hwang PA, Hoffman HJ：Neuroimaging for investigation of seizures in children. Pediatric Neurosurg 18：105-116, 1992

25）Otsubo H, Hwang PA, Gilday DL, Chuang SH, Becker LE, Jay V, Hoffman HJ：Location of epileptic foci on interictal and postictal single photon emission tomography in children with localization-related epilepsy. J Child Neurol 10：375-381, 1995

26）Otsubo H, Hwang PA, Hunjan A, Armstrong D, Holowka S, Drake JM, Hoffman HJ：Use of frameless stereotaxy with location of electroencephalographic electrodes on three-dimensional computed tomographic images in epilepsy surgery. J Clin Neurophysiol 12：363-371, 1995

27）Otsubo H, Steinlin M, Hwang PA, Sharma R, Jay V, Becker LE, Hoffman HJ, Blaser S：Positive epileptiform discharges in children with neuronal migration disorders. Pediatr Neurol 16：23-31, 1997

28）Otsubo H, Ochi A, Elliott I, Chuang SH, Rutka JT, Jay V, Aung M, Sobel DF, Snead OC：MEG predicts epileptic zone in lesional extrahippocampal epilepsy：12 pediatric surgery cases. Epilepsia 42：1523-1530, 2001

29）Otsubo H, Chitoku S, Ochi A, Jay V, Rutka JT, Smith ML, Elliott IM, Snead OCⅢ：Malignant rolandic-sylvian epilepsy in children：diagnosis, treatment, and outcome. Neurology 57：590-596, 2001

30）Rutka JT, Otsubo H, Kitano S, Sakamoto H, Shirasawa A, Ochi A, Snead OCⅢ：Utility of digital camera-derived intraoperative images in the planning of epilepsy surgery for children. Neurosurgery 45：1186-1191, 1999

31）Snead OCⅢ：Surgical treatment of medically refractory epilepsy in childhood. Brain Dev 23：199-207, 2001