Neurological Surgery 脳神経外科34巻9号

2006年09月発行

症例

定位放射線手術後のnidus内に血管新生を伴って出血を繰り返した脳動静脈奇形の1例

著者： 粟野貴志¹ 加納利和¹ 永岡右章¹ 木村重吉² 加納恒男¹ 木戸悟郎² 片山容一¹ 小谷昭夫²

所属機関： ¹日本大学医学部脳神経外科 ²春日部市立市民病院脳神経外科

ページ範囲：P.927 - P.932

Ⅰ．は じ め に

　Stereotactic radiosurgery（SRS）後，出血を伴って増大する腫瘤が形成された AVM（arteriovenous malformation）症例について組織学的検討を行ったので報告する．

参考文献

1）György TS, Isabelle S, Danielle B, Jacques B, Marc L：Immunohistochemical analysis of a cerebral arteriovenous malformation obliterated by radiosurgery and presenting with re-bleeding：case report. Neurol Res 25：718-721, 2003

2）Koizumi T, Shiraishi T, Hagihara N, Tabuchi K, Hayashi T, Kawano T：Expression of vascular endothelial growth factors and their receptors in and around intracranial arteriovenous malformations. Neurosurgery 50：117-126, 2002

3）Kurita H, Sasaki T, Kawamoto S, Taniguchi M, Kitanaka C, Nakaguchi H, Kirino T：Chronic encapsulated expanding hematoma in association with gamma knife stereotactic radiosurgery for a cerebral arteriovenous malformation：case report. J Neurosurg 84：874-878, 1996

4）Lindqvist M, Karlsson B, Guo WY, Kihlstro¨m L, Lippitz B, Yamamoto M：Angiographic long-term follow-up data for arteriovenous malformations previously proven to be obliterated after Gamma Knife radiosurgery. Neurosurgery 46：803-810, 2000

5）Millauer B, Wizigmannn-Voos S, Schnurch H, Martinez R, Moller NPH, Risau W, Ullrich A：High affinity VEGF binding and development expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72：835-846, 1993

6）Plate KH, Breier G, Millauer B, Ullrich A, Risau W：Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Res 53：5822-5827, 1993

7）Schneider BF, Eberhard DA, Steiner LE：Histopathology of arteriovenous malformations after gamma knife radiosurgery. J Neurosurg 87：352-357, 1997

8）Stein I, Neeman M, Shweiki D, Itin A, Keshet E：Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol Cell Biol 15：5363-5368, 1995

9）Sure U, Battenberg E, Dempfle A, Tirakotai W, Bien S, Bertalanffy H：Hypoxia-inducible factor and vascular endothelial growth factor are expressed more frequently in embolized than in nonembolized cerebral arteriovenous malformations. Neurosurgery 55：663-670, 2004

10）Yamamoto M, Jimbo M, Kobayashi M, Toyoda C, Ide M, Tanaka N, Lindquist C, Steiner L：Long-term results of radiosurgery for arteriovenous malformation：neurodiagnostic imaging and histological studies of angiographically confirmed nidus obliteration. Surg Neurol 37：219-230, 1992

11）Yamamoto M, Jimbo M, Hara M, Saino I, Mori K：Gamma knife radiosurgery for arteriovenous malformations：long term follow-up results focusing on complications occurring more than 5 years after irradiation. Neurosurgery 38：906-914, 1996