Neurological Surgery 脳神経外科35巻4号

2007年04月発行

連載 脳神経外科医療のtranslational research（6）

脳・神経刺激療法のtranslational research

著者： 深谷親¹ 片山容一¹

所属機関： ¹日本大学医学部脳神経外科・先端医学講座応用システム神経科学

ページ範囲：P.391 - P.399

Ⅰ．はじめに

　脳神経外科の様々な領域は，大まかには臨床の場で培われた経験に基づく知見と論理的な方法論に基づく研究の成果の2つを基盤に発展してきたといえよう．その中でも脳・神経刺激療法を中心とした定位・機能神経外科という領域は，研究が寄与する部分の特に多い分野の1つといえる．既に，脳・神経刺激療法は脳神経外科医療の中で1つの分野として確立しているが，これまでの長い歴史の中で数多くの基礎あるいは臨床研究の成果を基盤として発展してきた．そして，これからの発展もこうした研究成果なしにはあり得ないであろう．事実，この領域は，近年の電子工学技術の進歩に伴い，さらなる大きな発展が期待されている．本稿では，定位・機能神経外科領域の基盤となった主たる研究の流れを初めに概観する．さらに，神経刺激の作用機序の解明，新たな刺激部位や適応疾患拡大のための基礎ならびに臨床研究について記載し，最後に今後の展望について述べる．

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