Neurological Surgery 脳神経外科37巻6号

2009年06月発行

連載 脳神経外科疾患治療のスタンダード

7．不随意運動症に対する脳深部刺激療法

著者： 上利崇¹ 伊達勲¹

所属機関： ¹岡山大学大学院医歯薬学総合研究科脳神経外科

ページ範囲：P.597 - P.607

Ⅰ．脳深部刺激療法の最近の動向

　脳深部刺激療法（deep brain stimulation：DBS）は定位脳手術手技を用いて深部電極を留置し，脳のさまざまな標的部位に対して電気刺激を行う治療法である．

　不随意運動症に対する外科治療としてこれまで定位脳手術による破壊・凝固術が主であったが，DBSは①脳を破壊することなく，破壊・凝固と同等の効果を得ることができる，②両側の手術が破壊術と比較して安全に行える，③刺激条件を変更することで刺激による副作用を消失させ，症状の変化に合わせて調整することが可能である，という大きな利点があり，現在，破壊・凝固手術に取って代わっている．

参考文献

1）Alterman RL, Miravite J, Weisz D, Shils JL, Bressman SB, Tagliati M：Sixty hertz pallidal deep brain stimulation for primary torsion dystonia. Neurology 69：681-688, 2007

2）Anderson VC, Burchiel KJ, Hogarth P, Favre J, Hammerstad JP：Pallidal vs subthalamic nucleus deep brain stimulation in Parkinson disease. Arch Neurol 62：554-560, 2005

3）Andrade-Souza YM, Schwalb JM, Hamani C, Eltahawy H, Hoque T, Saint-Cyr J, Lozano AM：Comparison of three methods of targeting the subthalamic nucleus for chronic stimulation in Parkinson's disease. Neurosurgery 62 Suppl 2：875-883, 2008

4）Ardouin C, Pillon B, Peiffer E, Bejjani P, Limousin P, Damier P, Arnulf I, Benabid AL, Agid Y, Pollak P：Bilateral subthalamic or pallidal stimulation for Parkinson's disease affects neither memory nor executive functions：a consecutive series of 62 patients. Ann Neurol 46：217-223, 1999

5）Benabid AL, Pollak P, Gao D, Hoffmann D, Limousin P, Gay E, Payen I, Benazzouz A：Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. J Neurosurg 84：203-214, 1996

6）Bereznai B, Steude U, Seelos K, Bötzel K：Chronic high-frequency globus pallidus internus stimulation in different types of dystonia：a clinical, video, and MRI report of six patients presenting with segmental, cervical, and generalized dystonia. Mov Disord 17：138-144, 2002

7）Berney A, Vingerhoets F, Perrin A, Guex P, Villemure JG, Burkhard PR, Benkelfat C, Ghika J：Effect on mood of subthalamic DBS for Parkinson's disease：a consecutive series of 24 patients. Neurology 59：1427-1429, 2002

8）Binder DK, Rau GM, Starr PA：Risk factors for hemorrhage during microelectrode-guided deep brain stimulator implantation for movement disorders. Neurosurgery 56：722-732, 2005

9）Birdno MJ, Grill WM：Mechanisms of deep brain stimulation in movement disorders as revealed by changes in stimulus frequency. Neurotherapeutics 5：14-25, 2008

10）Burchiel KJ, Anderson VC, Favre J, Hammerstad JP：Comparison of pallidal and subthalamic nucleus deep brain stimulation for advanced Parkinson's disease：results of a randomized, blinded pilot study. Neurosurgery 45：1375-1382, 1999

11）Burkhard PR, Vingerhoets FJ, Berney A, Bogousslavsky J, Villemure JG, Ghika J：Suicide after successful deep brain stimulation for movement disorders. Neurology 63：2170-2172, 2004

12）Charles PD, Van Blercom N, Krack P, Lee SL, Xie J, Besson G, Benabid AL, Pollak P：Predictors of effective bilateral subthalamic nucleus stimulation for PD. Neurology 59：932-934, 2002

13）Chou KL, Hurtig HI, Jaggi JL, Baltuch GH：Bilateral subthalamic nucleus deep brain stimulation in a patient with cervical dystonia and essential tremor. Mov Disord 20：377-380, 2005

14）Coubes P, Cif L, El Fertit H, Hemm S, Vayssiere N, Serrat S, Picot MC, Tuffery S, Claustres M, Echenne B, Frerebeau P：Electrical stimulation of the globus pallidus internus in patients with primary generalized dystonia：long-term results. J Neurosurg 101：189-194, 2004

15）Damier P, Thobois S, Witjas T, Cuny E, Derost P, Raoul S, Mertens P, Peragut JC, Lemaire JJ, Burbaud P, Nguyen JM, Llorca PM, Rascol O：French Stimulation for Tardive Dyskinesia (STARDYS) Study Group：Bilateral deep brain stimulation of the globus pallidus to treat tardive dyskineisa. Arch Gen Psychiatry 64：170-176, 2007

16）Deep-Brain Stimulation for Parkinson's Disease Study Group：Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. N Engl J Med 345：956-963, 2001

17）Deuschl G, Schade-Brittinger C, Krack P, Volkmann J, Schäfer H, Bötzel K, Daniels C, Deutschländer A, Dillmann U, Eisner W, Gruber D, Hamel W, Herzog J, Hilker R, Klebe S, Kloss M, Koy J, Krause M, Kupsch A, Lorenz D, Lorenzl S, Mehdorn HM, Moringlane JR, Oertel W, Pinsker MO, Reichmann H, Reuss A, Schneider GH, Schnitzler A, Steude U, Sturm V, Timmermann L, Tronnier V, Trottenberg T, Wojtecki L, Wolf E, Poewe W, Voges J； German Parkinson Study Group, Neurostimulation Section：A randomized trial of deep brain stimulation for Parkinson's disease. N Engl J Med 355：896-908, 2006

18）Dostrovsky JO, Lozano AM：Mechanisms of deep brain stimulation. Mov Disord 17 Suppl 3：S63-S68, 2003

19）Eltahawy HA, Saint-Cyr J, Giladi N, Lang AE, Lozano AM：Primary dystonia is more responsive than secondary dystonia to pallidal interventions：outcome after pallidotomy or pallidal deep brain stimulation. Neurosurgery 54：613-619, 2004

20）Fahn S, Marsden CD, Calne DB：Classification and investigation of dystonia. In：Marsden CD, Fahn S (eds), Movement Disorders 2. Butterworths, London, 1987, pp332-358

21）Ferraye MU, DebûB, Fraix V, Xie-Brustolin J, Chabardès S, Krack P, Benabid AL, Pollak P：Effects of subthalamic nucleus stimulation and levodopa on freezing of gait in Parkinson disease. Neurology 70：1431-1437, 2008

22）Fields JA, Tröster AI, Wilkinson SB, Pahwa R, Koller WC：Cognitive outcome following staged bilateral pallidal stimulation for the treatment of Parkinson's disease. Clin Neurol Neurosurg 101：182-188, 1999

23）Fukaya C, Katayama Y, Kano T, Nagaoka T, Kobayashi K, Oshima H, Yamamoto T：Thalamic deep brain stimulation for writer's cramp. J Neurosurg 107：977-982, 2007

24）Gorgulho A, De Salles AA, Frighetto L, Behnke E：Incidence of hemorrhage associated with electrophysiological studies performed using macroelectrodes and microelectrodes in functional neurosurgery. J Neurosurg 102：888-896, 2005

25）Goto S, Tsuiki H, Soyama N, Okamura A, Yamada K, Yoshikawa M, Hashimoto Y, Ushio Y：Sterotactic selective Vo-complex thalamotomy in a patient with dystonic writer's cramp. Neurology 49：1173-1174, 1997

26）Goto S, Yamada K：Long term continuous bilateral pallidal stimulation produces stimulation independent relief of cervical dystonia. J Neurol Neurosurg Psychiatry 75：1506-1507, 2004

27）Hälbig TD, Gruber D, Kopp UA, Schneider GH, Trottenberg T, Kupsch A：Pallidal stimulation in dystonia：effects on cognition, mood, and quality of life. J Neurol Neurosurg Psychiatry 76：1713-1716, 2005

28）Hamani C, Richter E, Schwalb JM, Lozano AM：Bilateral subthalamic nucleus stimulation for Parkinson's disease：a systematic review of the clinical literature. Neurosurgery 56：1313-1321, 2005

29）Hariz GM, Blomstedt P, Koskinen LO：Long-term effect of deep brain stimulation for essential tremor on activities of daily living and health-related quality of life. Acta Neurol Scand 118：387-394, 2008

30）Hariz MI, Krack P, Alesch F, Augustinsson LE, Bosch A, Ekberg R, Johansson F, Johnels B, Meyerson BA, N’Guyen JP, Pinter M, Pollak P, von Raison F, Rehncrona S, Speelman JD, Sydow O, Benabid AL：Multicentre European study of thalamic stimulation for parkinsonian tremor：a 6 year follow-up. J Neurol Neurosurg Psychiatry 79：694-699, 2008

31）Herzog J, Fietzek U, Hamel W, Morsnowski A, Steigerwald F, Schrader B, Weinert D, Pfister G, Müller D, Mehdorn HM, Deuschl G, Volkmann J：Most effective stimulation site in subthalamic deep brain stimulation for Parkinson's disease. Mov Disord 19：1050-1054, 2004

32）Herzog J, Hamel W, Wenzelburger R, Pötter M, Pinsker MO, Bartussek J, Morsnowski A, Steigerwald F, Deuschl G, Volkmann J：Kinematic analysis of thalamic versus subthalamic neurostimulation in postural and intention tremor. Brain 130：1608-1625, 2007

33）Houeto JL, Damier P, Bejjani PB, Staedler C, Bonnet AM, Arnulf I, Pidoux B, Dormont D, Cornu P, Agid Y：Subthalamic stimulation in Parkinson disease：a multidisciplinary approach. Arch Neurol 57：461-465, 2000

34）Houeto JL, Mesnage V, Mallet L, Pillon B, Gargiulo M, du Moncel ST, Bonnet AM, Pidoux B, Dormont D, Cornu P, Agid Y：Behavioural disorders, Parkinson's disease and subthalamic stimulation. J Neurol Neurosurg Psychiatry 72：701-707, 2002

35）Johnson MD, Miocinovic S, McIntyre CC, Vitek JL：Mechanisms and targets of deep brain stimulation in movement disorders. Neurotherapeutics 5：294-308, 2008

36）Katayama Y, Kasai M, Oshima H, Fukaya C, Yamamoto T, Ogawa K, Mizutani T：Subthalamic nucleus stimulation for Parkinson disease：benefits observed in levodopa-intolerant patients. J Neurosurg 95：213-221, 2001

37）Kiss ZH, Doig K, Eliasziw M, Ranawaya R, Suchowersky O：The Canadian multicenter trial of pallidal deep brain stimulation for cervical dystonia：preliminary results in three patients. Neurosurg Focus 17：E5, 2004

38）Kitagawa M, Murata J, Kikuchi S, Sawamura Y, Saito H, Sasaki H, Tashiro K：Deep brain stimulation of subthalamic area for severe proximal tremor. Neurology 55：114-116, 2000

39）Kleiner-Fisman G, Herzog J, Fisman DN, Tamma F, Lyons KE, Pahwa R, Lang AE, Deuschl G：Subthalamic nucleus deep brain stimulation：summary and meta-analysis of outcomes. Mov Disord 21 Suppl 14：S290-S304, 2006

40）Kleiner-Fisman G, Liang GS, Moberg PJ, Ruocco AC, Hurtig HI, Baltuch GH, Jaggi JL, Stern MB：Subthalamic nucleus deep brain stimulation for severe idiopathic dystonia：impact on severity, neuropsychological status, and quality of life. J Neurosurg 107：29-36, 2007

41）Koike Y, Shima F, Nakamizo A, Miyagi Y：Direct localization of subthalamic nucleus supplemented by single-track electrophysiological guidance in deep brain stimulation lead implantation：techniques and clinical results. Stereotact Funct Neurosurg 86：173-178, 2008

42）Koller W, Pahwa R, Busenbark K, Hubble J, Wilkinson S, Lang A, Tuite P, Sime E, Lazano A, Hauser R, Malapira T, Smith D, Tarsy D, Miyawaki E, Norregaard T, Kormos T, Olanow CW：High-frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor. Ann Neurol 42：292-299, 1997

43）Koller WC, Lyons KE, Wilkinson SB, Troster AI, Pahwa R：Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor. Mov Disord 16：464-468, 2001

44）Krack P, Batir A, Van Blercom N, Chabardes S, Fraix V, Ardouin C, Koudsie A, Limousin PD, Benazzouz A, LeBas JF, Benabid AL, Pollak P：Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease. N Engl J Med 349：1925-1934, 2003

45）Krause M, Fogel W, Kloss M, Rasche D, Volkmann J, Tronnier V：Pallidal stimulation for dystonia. Neurosurgery 55：1361-1370, 2004

46）Krauss JK, Loher TJ, Weigel R, Capelle HH, Weber S, Burgunder JM：Chronic stimulation of the globus pallidus internus for treatment of non-dYT1 generalized dystonia and choreoathetosis：2-year follow up. J Neurosurg 98：785-792, 2003

47）Kumar R, Lozano AM, Kim YJ, Hutchison WD, Sime E, Halket E, Lang AE：Double-blind evaluation of subthalamic nucleus deep brain stimulation in advanced Parkinson's disease. Neurology 51：850-855, 1998

48）Kupsch A, Benecke R, Müller J, Trottenberg T, Schneider GH, Poewe W, Eisner W, Wolters A, Müller JU, Deuschl G, Pinsker MO, Skogseid IM, Roeste GK, Vollmer-Haase J, Brentrup A, Krause M, Tronnier V, Schnitzler A, Voges J, Nikkhah G, Vesper J, Naumann M, Volkmann J：Deep-Brain Stimulation for Dystonia Study Group：Pallidal deep-brain stimulation in primary generalized or segmental dystonia. N Engl J Med 355：1978-1990, 2006

49）Lefaucheur JP, Gurruchaga JM, Pollin B, von Raison F, Mohsen N, Shin M, Ménard-Lefaucheur I, Oshino S, Kishima H, Fénelon G, Rémy P, Cesaro P, Gabriel I, Brugières P, Keravel Y, Nguyen JP：Outcome of bilateral subthalamic nucleus stimulation in the treatment of Parkinson's disease：correlation with intra-operative multi-unit recordings but not with the type of anaesthesia. Eur Neurol 60：186-199, 2008

50）Limousin P, Speelman JD, Gielen F, Janssens M：Multicentre European study of thalamic stimulation in parkinsonian and essential tremor. J Neurol Neurosurg Psychiatry 66：289-296, 1999

51）Loher TJ, Capelle HH, Kaelin-Lang A, Weber S, Weigel R, Burgunder JM, Krauss JK：Deep brain stimulation for dystonia：outcome at long-term follow-up. J Neurol 255：881-884, 2008

52）Lyons KE, Pahwa R, Comella CL, Eisa MS, Elble RJ, Fahn S, Jankovic J, Juncos JL, Koller WC, Ondo WG, Sethi KD, Stern MB, Tanner CM, Tintner R, Watts RL：Benefits and risks of pharmacological treatments for essential tremor. Drug Saf 26：461-481, 2003

53）Machado A, Rezai AR, Kopell BH, Gross RE, Sharan AD, Benabid AL：Deep brain stimulation for Parkinson's disease：surgical technique and perioperative management. Mov Disord 21 Suppl 14：S247-S258, 2006

54）Mehrkens JH, Bötzel K, Steude U, Zeitler K, Schnitzler A, Sturm V, Voges J：Long-term efficacy and safety of chronic globus pallidus internus stimulation in different types of primary dystonia. Stereotact Funct Neurosurg 87：8-17, 2009

55）Minguez-Castellanos A, Escamilla-Sevilla F, Katati MJ, Martin-Linares JM, Meersmans M, Ortega-Moreno A, Arjona V：Different patterns of medication change after subthalamic or pallidal stimulation for Parkinson's disease：target related effect or selection bias? J Neurol Neurosurg Psychiatry 76：34-39, 2005

56）Molinuevo JL, Valldeoriola F, Tolosa E, Rumia J, Valls-Sole J, Roldan H, Ferrer E：Levodopa withdrawal after bilateral subthalamic nucleus stimulation in advanced Parkinson disease. Arch Neurol 57：983-988, 2000

57）Moro E, Scerrati M, Romito LM, Roselli R, Tonali P, Albanese A：Chronic subthalamic nucleus stimulation reduces medication requirements in Parkinson's disease. Neurology 53：85-90, 1999

58）Mueller J, Skogseid IM, Benecke R, Kupsch A, Trottenberg T, Poewe W, Schneider GH, Eisner W, Wolters A, Müller JU, Deuschl G, Pinsker MO, Roeste GK, Vollmer-Haase J, Brentrup A, Krause M, Tronnier V, Schnitzler A, Voges J, Nikkhah G, Vesper J, Naumann M, Volkmann J；Deep-Brain Stimulation for Dystonia Study Group：Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia：results from a prospective, randomized sham-controlled trial. Mov Disord 23：131-134, 2008

59）Munro-Davies LE, Winter J, Aziz TZ, Stein JF：The role of the pedunculopontine region in basal-ganglia mechanisms of akinesia. Exp Brain Res 129：511-517, 1999

60）Murata J, Kitagawa M, Uesugi H, Saito H, Iwasaki Y, Kikuchi S, Tashiro K, Sawamura Y：Electrical stimulation of the posterior subthalamic area for the treatment of intractable proximal tremor. J Neurosurg 99：708-715, 2003

61）Nandi D, Aziz TZ, Giladi N, et al：Reversal of akinesia in experimental parkinsonism by GABA antagonist microinjections in the pedunculopontine nucleus. Brain 125：2418-2430, 2002

62）Novak KE, Nenonene EK, Bernstein LP, Vergenz S, Cozzens JW, Rezak M：Succesful bilateral subthalamic nucleus stimulation for segmental dystonia after unilateral pallidotomy. Stereotact Funct Neurosurg 86：80-86, 2007

63）Ohye C, Shibazaki T, Hirai T, Wada H, Hirato M, Kawashima Y：Further physiological observations on ventralis intermedius neurons in the human thalamus. J Neurophysiol 61：488-500, 1989

64）Ondo W, Almaguer M, Jankovic J, Simpson RK：Thalamic deep brain stimulation：comparison between unilateral and bilateral placement. Arch Neurol 58：218 -222, 2001

65）Ozelius LJ, Hewett JW, Page CE, Bressman SB, Kramer PL, Shalish C, de Leon D, Brin MF, Raymond D, Corey DP, Fahn S, Risch NJ, Buckler AJ, Gusella JF, Breakefield XO：The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein. Nat Genet 17：40-48, 1997

66）Pahwa R, Lyons KE, Wilkinson SB, Tröster AI, Overman J, Kieltyka J, Koller WC：Comparison of thalamotomy to deep brain stimulation of the thalamus in essential tremor. Mov Disord 16：140-143, 2001

67）Pahwa R, Lyons KE, Wilkinson SB, Simpson RK Jr, Ondo WG, Tarsy D, Norregaard T, Hubble JP, Smith DA, Hauser RA, Jankovic J：Long-term evaluation of deep brain stimulation of the thalamus. J Neurosurg 104：506-512, 2006

68）Parsons TD, Rogers SA, Braaten AJ, Woods SP, Tröster AI：Cognitive sequelae of subthalamic nucleus deep brain stimulation in Parkinson's disease：a meta-analysis. Lancet Neurol 5：578-588, 2006

69）Peppe A, Pierantozzi M, Bassi A, Altibrandi MG, Brusa L, Stefani A, Stanzione P, Mazzone P：Stimulation of the subthalamic nucleus compared with the globus pallidus internus in patients with Parkinson disease. J Neurosurg 101：195-200, 2004

70）Pillon B, Ardouin C, Damier P, Krack P, Houeto JL, Klinger H, Bonnet AM, Pollak P, Benabid AL, Agid Y：Neuropsychological changes between “off” and “on” STN or GPi stimulation in Parkinson's disease. Neurology 55：411-418, 2000

71）Pillon B, Ardouin C, Dujardin K, Vittini P, Pelissolo A, Cottencin O, Vercueil L, Houeto JL, Krystkowiak P, Agid Y, Destée A, Pollak P, Vidailhet M；French SPIDY Study Group：Preservation of cognitive function in dystonia treated by pallidal stimulation. Neurology 66：1556-1558, 2006

72）Plaha P, Patel NK, Gill SS：Stimulation of the subthalamic region for essential tremor. J Neurosurg 101：48-54, 2004

73）Plaha P, Gill SS：Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson's disease. Neuroreport 16：1883-1887, 2005

74）Plaha P, Ben-Shlomo Y, Patel NK, Gill SS：Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism. Brain 129：1732-1747, 2006

75）Plaha P, Khan S, Gill SS：Bilateral stimulation of the caudal zona incerta nucleus for tremor control. J Neurol Neurosurg Psychiatry 79：504-513, 2008

76）Putzke JD, Wharen RE Jr, Wszolek ZK, Turk MF, Strongosky AJ, Uitti RJ：Thalamic deep brain stimulation for tremor-predominant Parkinson's disease. Parkinsonism Relat Disord 10：81-88, 2003

77）Putzke JD, Wharen RE Jr, Obwegeser AA, Wszolek ZK, Lucas JA, Turk MF, Uitti RJ：Thalamic deep brain stimulation for essential tremor：recommendations for long-term outcome analysis. Can J Neurol Sci 31：333-342, 2004

78）Putzke JD, Uitti RJ, Obwegeser AA, Wszolek ZK, Wharen RE：Bilateral thalamic deep brain stimulation：midline tremor control. J Neurol Neurosurg Psychiatry 76：684-690, 2005

79）Rehncrona S, Johnels B, Widner H, Törnqvist AL, Hariz M, Sydow O：Long-term efficacy of thalamic deep brain stimulation for tremor：double-blind assessments. Mov Disord 18：163-170, 2003

80）Rodriguez-Oroz MC, Obeso JA, Lang AE, Houeto JL, Pollak P, Rehncrona S, Kulisevsky J, Albanese A, Volkmann J, Hariz MI, Quinn NP, Speelman JD, Guridi J, Zamarbide I, Gironell A, Molet J, Pascual-Sedano B, Pidoux B, Bonnet AM, Agid Y, Xie J, Benabid AL, Lozano AM, Saint-Cyr J, Romito L, Contarino MF, Scerrati M, Fraix V, Van Blercom N：Bilateral deep brain stimulation in Parkinson's disease：a multicentre study with 4 years follow-up. Brain 128：2240-2249, 2005

81）Russmann H, Ghika J, Villemure JG, Robert B, Bogousslavsky J, Burkhard PR, Vingerhoets FJ：Subthalamic nucleus deep brain stimulation in Parkinson disease patients over age 70 years. Neurology 63：1952-1954, 2004

82）Saint-Cyr JA, Trépanier LL, Kumar R, Lozano AM, Lang AE：Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson's disease. Brain 123：2091-2108, 2000

83）Schüpbach WM, Chastan N, Welter ML, Houeto JL, Mesnage V, Bonnet AM, Czernecki V, Maltête D, Hartmann A, Mallet L, Pidoux B, Dormont D, Navarro S, Cornu P, Mallet A, Agid Y：Stimulation of the subthalamic nucleus in Parkinson's disease：a 5 year follow up. J Neurol Neurosurg Psychiatry 76：1640-1644, 2005

84）Schüpbach WM, Maltête D, Houeto JL, du Montcel ST, Mallet L, Welter ML, Gargiulo M, Béhar C, Bonnet AM, Czernecki V, Pidoux B, Navarro S, Dormont D, Cornu P, Agid Y：Neurosurgery at an earlier stage of Parkinson disease：a randomized, controlled trial. Neurology 68：267-271, 2007

85）Schuurman PR, Bosch DA, Bossuyt PM, Bonsel GJ, van Someren EJ, de Bie RM, Merkus MP, Speelman JD：A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor. N Engl J Med 342：461-468, 2000

86）Shibata T, Hirashima Y, Ikeda H, Asahi T, Hayashi N, Endo S：Stereotactic Voa-Vop complex thalmotomy for writer's cramp. Eur Neurol 53：38-39, 2005

87）Slavin KV, Thulborn KR, Wess C, Nersesyan H：Direct visualization of the human subthalamic nucleus with 3T MR imaging. AJNR Am J Neuroradiol 27：80-84, 2006

88）Soulas T, Gurruchaga JM, Palfi S, Cesaro P, Nguyen JP, Fénelon G：Attempted and completed suicides after subthalamic nucleus stimulation for Parkinson's disease. J Neurol Neurosurg Psychiatry 79：952-954, 2008

89）Stefani A, Lozano AM, Peppe A, Stanzione P, Galati S, Tropepi D, Pierantozzi M, Brusa L, Scarnati E, Mazzone P：Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease. Brain 130：1596-1607, 2007

90）Sun B, Chen S, Zhan S, Le W, Krahl S：Subthalamic nucleus stimulation for primary dystonia and tardive dystonia. Acta Neurochir Suppl 97：207-214, 2007

91）Sydow O, Thobois S, Alesch F, Speelman JD：Multicentre European study of thalamic stimulation in essential tremor：a six year follow up. J Neurol Neurosurg Psychiatry 74：1387-1391, 2003

92）Taha JM, Janszen MA, Favre J：Thalamic deep brain stimulation for the treatment of head, voice, and bilateral limb tremor. J Neurosurg 91：68-72, 1999

93）Taira T, Hori T：Stereotactic ventrooralis thalamotomy for task-specfic focal hand dystonia (writer's cramp). Stereotact Funct Neurosurg 80：88-91, 2003

94）Takeshita S, Kurisu K, Trop L, Arita K, Akimitsu T, Verhoeff NP：Effect of subthalamic stimulation on mood state in Parkinson's disease：evaluation of previous facts and problems. Neurosurg Rev 28：179-186, 2005

95）Tasker RR：Deep brain stimulation is preferable to thalamotomy for tremor suppression. Surg Neurol 49：145-153, 1998

96）Temel Y, Kessels A, Tan S, Topdag A, Boon P, Visser-Vandewalle V：Behavioural changes after bilateral subthalamic stimulation in advanced Parkinson disease：a systematic review. Parkinsonism Relat Disord 12：265-272, 2006

97）Temel Y, Wilbrink P, Duits A, Boon P, Tromp S, Ackermans L, van Kranen-Mastenbroek V, Weber W, Visser-Vandewalle V：Single electrode and multiple electrode guided electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease. Neurosurgery 61 Suppl 2：346-355, 2007

98）Trottenberg T, Paul G, Meissner W, Maier-Hauff K, Taschner C, Kupsch A：Pallidal and thalamic neurostimulation in severe tardive dystonia. J Neurol Neurosurg Psychiatry 70：557-559, 2001

99）Vidailhet M, Vercueil L, Houeto JL, Krystkowiak P, Benabid AL, Cornu P, Lagrange C, Tézenas du Montcel S, Dormont D, Grand S, Blond S, Detante O, Pillon B, Ardouin C, Agid Y, Destée A, Pollak P：French Stimulation du Pallidum Interne dans la Dystonie (SPIDY) Study Group：Bilateral deep-brain stimulation of the globus pallidus in praimary generalized dystonia. N Engl J Med 352：459-467, 2005

100）Volkmann J, Allert N, Voges J, Sturm V, Schnitzler A, Freund HJ：Long-term results of bilateral pallidal stimulation in Parkinson's disease. Ann Neurol 55：871-875, 2004

101）Voon V, Krack P, Lang AE, Lozano AM, Dujardin K, Schüpbach M, D’Ambrosia J, Thobois S, Tamma F, Herzog J, Speelman JD, Samanta J, Kubu C, Rossignol H, Poon YY, Saint-Cyr JA, Ardouin C, Moro E：A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease. Brain 131：2720-2728, 2008

102）Welter ML, Houeto JL, Tezenas du Montcel S, Mesnage V, Bonnet AM, Pillon B, Arnulf I, Pidoux B, Dormont D, Cornu P, Agid Y：Clinical predictive factors of subthalamic stimulation in Parkinson's disease. Brain 125：575-583, 2002

103）Yamada K, Goto S, Hamasaki T, Kuratsu JI：Effect of bilateral subthalamic nucleus stimulation on levodopa-unresponsive axial symptoms in Parkinson's disease. Acta Neurochir (Wien) 150：15-22, 2008

104）Yianni J, Nandi D, Shad A, Bain P, Gregory R, Aziz T：Incresed risk of lead fracture and migration in dystonia compared with other movement disorders following deep brain stimulation. J Clin Neurosci 11：243-245, 2004