Neurological Surgery 脳神経外科38巻6号

2010年06月発行

総説

脳虚血に対する幹細胞移植

著者： 本望修¹² 寳金清博³

所属機関： ¹札幌医科大学神経再生医学講座 ²札幌医科大学脳神経外科学講座 ³北海道大学大学院医学研究科神経病態学神経外科学

ページ範囲：P.515 - P.520

Ⅰ．緒言

　われわれは，1990年代初期から神経系細胞をはじめとする種々のドナー細胞の研究を開始し，特に神経幹細胞やES細胞（embryonic stem cell）などの幹細胞を用いた基礎研究を展開してきた．近年では実用化を念頭に臨床応用に最短位置と予想される骨髄細胞をドナー細胞とした神経再生研究に注目し，基礎的研究成果を数多く報告してきた^{1,2-9,11,13-21)}．その中でも特に神経再生作用の強い細胞群（骨髄間葉系幹細胞）は，経静脈内投与でも実験的脳梗塞に対して著明な治療効果が認められることを報告してきた．これらの基礎研究結果に基づき，2007年1月より脳梗塞亜急性期の患者を対象とした自己骨髄間葉系幹細胞の静脈内投与について，その安全性と治療効果について検討している．

参考文献

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