文献詳細
文献概要
連載 脳卒中専門医に必要な基本的知識
(2)脳卒中における血小板活性化とその制御
著者: 長尾毅彦1
所属機関: 1東京女子医科大学神経内科
ページ範囲:P.879 - P.885
文献購入ページに移動Ⅰ.はじめに
脳卒中,特に脳梗塞では血管を閉塞する病的血栓が病態の主役であることは論をまたない.しかし,その血栓の組成は均質ではなく,症例によって大きく異なることはあまり理解されていない.その血栓の組成の違いに大きく関わっているのが血小板の動静である.本稿では,血小板を中心に脳梗塞における血栓止血学的側面を概説する.
脳卒中,特に脳梗塞では血管を閉塞する病的血栓が病態の主役であることは論をまたない.しかし,その血栓の組成は均質ではなく,症例によって大きく異なることはあまり理解されていない.その血栓の組成の違いに大きく関わっているのが血小板の動静である.本稿では,血小板を中心に脳梗塞における血栓止血学的側面を概説する.
参考文献
1) Ertugrul DT, Tutal E, Yildiz M, Akin O, Yalçin AA, Ure OS, Yilmaz H, Yavuz B, Deveci OS, Küçükazman M: Aspirin resistance is associated with glycemic control, the dose of aspirin, and obesity in type 2 diabetes mellitus. J Clin Endocrinol Metab 95:2897-2901, 2010
2) Gurbel PA, Tantry US, Shuldiner AR, Kereiakes DJ:Genotyping:one piece of the puzzle to personalize antiplatelet therapy. J Am Coll Cardiol 56:112-116, 2010
3) Hoshino K, Horiuchi H, Tada T, Tazaki J, Nishi E, Kawato M, Ikeda T, Yamamoto H, Akao M, Furukawa Y, Shizuta S, Toma M, Tamura T, Saito N, Doi T, Ozasa N, Jinnai T, Takahashi K, Watanabe H, Yoshikawa Y, Nishimoto N, Ouchi C, Morimoto T, Kita T, Kimura T:Clopidogrel resistance in Japanese patients scheduled for percutaneous coronary intervention. Circ J 73:336-342, 2009
4) Hosokawa K, Ohnishi T, Fukasawa M, Kondo T, Sameshima H, Koide T, Tanaka KA, Maruyama I:A microchip flow-chamber system for quantitative assessment of the platelet thrombus formation process. Microvasc Res 83:154-161, 2012
5) Jinnai T, Horiuchi H, Makiyama T, Tazaki J, Tada T, Akao M, Ono K, Hoshino K, Naruse Y, Takahashi K, Watanabe H, Kita T, Kimura T:Impact of CYP2C19 polymorphisms on the antiplatelet effect of clopidogrel in an actual clinical setting in Japan. Circ J 73:1498-1503, 2009
6) Lee M, Saver JL, Hong KS, Rao NM, Wu YL, Ovbiagele B:Risk-benefit profile of long-term dual-versus single-antiplatelet therapy among patients with ischemic stroke:a systematic review and meta-analysis. Ann Intern Med 159:463-470, 2013
7) Lordkipanidzé M, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG:A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease. Eur Heart J 28:1702-1708, 2007
8) Miyata S, Kada A, Nagatsuka K;ProGEAR study:Clinical impact of aspirin ‘resistance' on the secondary prevention of atherothrombosis. J Thromb Haemost 9(suppl2):257, 2011
9) 長尾毅彦,濱本 真,神田明美,宮崎徳蔵,赫 彰郎:凝血学的指標と脳梗塞の臨床.日本臨牀51(Suppl):424-432, 1993
10) Nagao T, Hamamoto M, Kanda A, Tsuganesawa T, Ueda M, Kobayashi K, Miyazaki T, Terashi A:Platelet activation is not involved in acceleration of the coagulation system in acute cardioembolic stroke with nonvalvular atrial fibrillation. Stroke 26:1365-1368, 1995
11) 長尾毅彦,片山泰朗,田久保秀樹:血液・凝血学的診断.日内会誌98:1249-1254, 2009
12) Price MJ, Berger PB, Teirstein PS, Tanguay JF, Angiolillo DJ, Spriggs D, Puri S, Robbins M, Garratt KN, Bertrand OF, Stillabower ME, Aragon JR, Kandzari DE, Stinis CT, Lee MS, Manoukian SV, Cannon CP, Schork NJ, Topol EJ;GRAVITAS Investigators:Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention:the GRAVITAS randomized trial. JAMA 305:1097-1105, 2011
13) Smith JP, Haddad EV, Taylor MB, Oram D, Blakemore D, Chen Q, Boutaud O, Oates JA:Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome. Hypertension 59:719-725, 2012
14) SPS3 Investigators, Benavente OR, Hart RG, McClure LA, Szychowski JM, Coffey CS, Pearce LA:Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. N Engl J Med 367:817-825, 2012
15) Trenk D, Zolk O, Fromm MF, Neumann FJ, Hochholzer W:Personalizing antiplatelet therapy with clopidogrel. Clin Pharmacol Ther 92:476-485, 2012
16) Wang Y, Wang Y, Zhao X, Liu L, Wang D, Wang C, Wang C, Li H, Meng X, Cui L, Jia J, Dong Q, Xu A, Zeng J, Li Y, Wang Z, Xia H, Johnston SC;CHANCE Investigators:Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med 369:11-19, 2013
17) Wong KS, Chen C, Fu J, Chang HM, Suwanwela NC, Huang YN, Han Z, Tan KS, Ratanakom D, Chollate P, Zhao Y, Koh A, Hao Q, Markus HS;CLAIR study investigators:Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis(CLAIR study):a randomised, open-label, blinded-endpoint trial. Lancet Neurol 9:489-497, 2010
18) 山崎昌子,内山真一郎:抗血小板薬の薬効評価.東女医大誌84:E49-E56, 2014
掲載誌情報