icon fsr

文献詳細

雑誌文献

Neurological Surgery 脳神経外科44巻11号

2016年11月発行

文献概要

総説

脳脊髄液運動の新知見

著者: 松前光紀1 厚見秀樹1 平山晃大1 林直一1 滝沢賢1 佐野史弥1 横田和馬1 反町隆俊1

所属機関: 1東海大学医学部外科学系脳神経外科学領域

ページ範囲:P.909 - P.924

文献購入ページに移動
Ⅰ.はじめに
 脳室およびくも膜下腔を満たす脳脊髄液(cerebrospinal fluid:CSF)は,脳ならびに脊髄の細胞外腔と自由に行き来し,盛んに物質の交換や代謝熱の放出などを行っている.さらに,脳・脊髄・神経・血管系に対する浮力効果,外力に対する緩衝作用および浸透圧調整などの重要な役割を担っている.近年CSFの役割やその動きについて新しい知見が発表されるようになり,本誌総説でもたびたびこれらの業績が紹介されてきた.本稿では,CSFに関する古い文献上の記載,CSFと細胞外液との関わり,最近注目される硬膜のリンパ管様構造物の発見,脳室とくも膜下腔におけるCSFの運動などについて文献を引用しながら考察する.

参考文献

1) Abdullah A, Hirayama A, Yatsushiro S, Matsumae M, Kuroda K:Cerebrospinal fluid image segmentation using spatial fuzzy clustering method with improved evolutionary Expectation Maximization. Conf Proc IEEE Eng Med Biol Soc 2013:3359-3362, 2013
2) Abe K, Ono Y, Yoneyama H, Nishina Y, Aihara Y, Okada Y, Sakai S:Assessment of cerebrospinal fluid flow patterns using the time-spatial labeling inversion pulse technique with 3T MRI:early clinical experiences. Neuroradiol J 27:268-279, 2014
3) Alcolado R, Weller RO, Parrish EP, Garrod D:The cranial arachnoid and pia mater in man:anatomical and ultrastructural observations. Neuropathol Appl Neurobiol 14:1-17, 1988
4) Alperin N, Hushek SG, Lee SH, Sivaramakrishnan A, Lichtor T:MRI study of cerebral blood flow and CSF flow dynamics in an upright posture:the effect of posture on the intracranial compliance and pressure. Acta Neurochir Suppl 95:177-181, 2005
5) Alperin N, Lee SH, Sivaramakrishnan A, Hushek SG:Quantifying the effect of posture on intracranial physiology in humans by MRI flow studies. J Magn Reson Imaging 22:591-596, 2005
6) Andres KH, von Düring M, Muszynski K, Schmidt RF:Nerve fibres and their terminals of the dura mater encephali of the rat. Anat Embryol(Berl)175:289-301, 1987
7) Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, Wiig H, Alitalo K:A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med 212:991-999, 2015
8) Atsumi H, Matsumae M, Hirayama A, Kuroda K:Measurements of intracranial pressure and compliance index using 1.5-T clinical MRI machine. Tokai J Exp Clin Med 39:34-43, 2014
9) Bakker EN, Bacskai BJ, Arbel-Ornath M, Aldea R, Bedussi B, Morris AW, Weller RO, Carare RO:Lymphatic clearance of the brain:perivascular, paravascular and significance for neurodegenerative diseases. Cell Mol Neurobiol 36:181-194, 2016
10) Bateman GA, Napier BD:External hydrocephalus in infants:six cases with MR venogram and flow quantification correlation. Childs Nerv Syst 27:2087-2096, 2011
11) Beckett A, Chen L, Verma A, Feinberg DA:Velocity phase imaging with simultaneous multi-slice EPI reveals respiration driven motion in spinal CSF. Proc Intl Soc Magn Reson Med 23:4445, 2015
12) Bergstrand G, Bergström M, Nordell B, Staåhlberg F, Ericsson A, Hemmingsson A, Sperber G, Thuomas KA, Jung B:Cardiac gated MR imaging of cerebrospinal fluid flow. J Comput Assist Tomogr 9:1003-1006, 1985
13) Bhadelia RA, Frederick E, Patz S, Dubey P, Erbay SH, Do-Dai D, Heilman C:Cough-associated headache in patients with Chiari I malformation:CSF Flow analysis by means of cine phase-contrast MR imaging. AJNR Am J Neuroradiol 32:739-742, 2011
14) Bito LZ, Davson H, Fenstermacher JD(eds):The ocular and cerebrospinal fluids:proceedings of a Fogarty International Center Symposium, Bethesda, Md., 3-6 May 1976. Academic Press, London, 1977
15) Bowsher D:Pathways of absorption of protein from the cerebrospinal fluid:an autoradiographic study in the cat. Anat Rec 128:23-39, 1957
16) Bowsher D:Cerebrospinal fluid dynamics in health and disease. C.C. Thomas, Springfield, 1960
17) Bradbury MW, Cole DF:The role of the lymphatic system in drainage of cerebrospinal fluid and aqueous humour. J Physiol 299:353-365, 1980
18) Brightman MW, Palay SL:The fine structure of ependyma in the brain of the rat. J Cell Biol 19:415-439, 1963
19) Brinker T, Stopa E, Morrison J, Klinge P:A new look at cerebrospinal fluid circulation. Fluids Barriers CNS 11:10, 2014
20) Brodbelt A, Stoodley M:CSF pathways:a review. Br J Neurosurg 21:510-520, 2007
21) Bucchieri F, Farina F, Zummo G, Cappello F:Lymphatic vessels of the dura mater:a new discovery? J Anat 227:702-703, 2015
22) Carare RO, Hawkes CA, Jeffrey M, Kalaria RN, Weller RO:Review:cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies(PEFA)in neurodegenerative disease with a focus on therapy. Neuropathol Appl Neurobiol 39:593-611, 2013
23) Cotugno D:De ischiade nervosa commentarius. Apud Rudolphum Gräffer, Viennae, 1770
24) Cousins J, Haughton V:Motion of the cerebellar tonsils in the foramen magnum during the cardiac cycle. AJNR Am J Neuroradiol 30:1587-1588, 2009
25) Crone C:The blood-brain barrier as a tight epithelium:where is information lacking? Ann N Y Acad Sci 481:174-185, 1986
26) Cserr HF:Convection of brain interstitial fluid and drainage into cerebrospinal fluid and deep cervical lymph. Wiss Z Karl Marx Univ Leipzig Math Naturwiss R 36:127-130, 1987
27) Cserr HF:Role of secretion and bulk flow of brain interstitial fluid in brain volume regulation. Ann N Y Acad Sci 529:9-20, 1988
28) Cushing H:The third circulation and its channels. Lancet 209:851-857, 1925
29) Deisenhammer F:The history of cerebrospinal fluid. In Deisenhammer F, Sellebjerg F, Teunissen CE, Tumani H(eds):Cerebrospinal Fluid in Clinical Neurology. Springer International Publishing, Cham, 2015, pp.3-16
30) Di Chiro G:Movement of the cerebrospinal fluid in human beings. Nature 204:290-291, 1964
31) Di leva A, Yaşargil MG:Liquor cotunnii:The history of cerebrospinal fluid in Domenico Cotugno's work. Neurosurgery 63:352-358;discussion 358, 2008
32) Di Matteo B, Tarabella V, Filardo G, Viganò A, Tomba P, Kon E, Marcacci M:Art in science:Giovanni Paolo Mascagni and the art of anatomy. Clin Orthop Relat Res 473:783-788, 2015
33) Dóczi T:Volume regulation of the brain tissue--a survey. Acta Neurochir(Wien)121:1-8, 1993
34) Drayer BP, Rosenbaum AE:Metrizamide brain penetrance. Acta Radiol Suppl 355:280-293, 1977
35) Drayer BP, Rosenbaum AE, Higman HB:Cerebrospinal fluid imaging using serial metrizamide CT cisternography. Neuroradiology 13:7-17, 1977
36) Dreha-Kulaczewski S, Joseph AA, Merboldt K-D, Ludwig H-C, Gärtner J, Frahm J:Inspiration is the major regulator of human CSF flow. J Neurosci 35:2485-2491, 2015
37) Du Boulay GH:Pulsatile movements in the CSF pathways. Br J Radiol 39:255-262, 1966
38) Edsbagge M, Tisell M, Jacobsson L, Wikkelso C:Spinal CSF absorption in healthy individuals. Am J Physiol Regul Integr Comp Physiol 287:R1450-1455, 2004
39) Erlich SS, McComb JG, Hyman S, Weiss MH:Ultrastructure of the orbital pathway for cerebrospinal fluid drainage in rabbits. J Neurosurg 70:926-931, 1989
40) Evans WA Jr:An encephalographic ratio for estimating ventricular enlargement and cerebral atrophy. Arch Neurol Psychiatry 47:931-937, 1942
41) Field EJ, Brierley JB:The retro-orbital tissues as a site of outflow of cerebrospinal fluid. Proc R Soc Med 42:447-450, 1949
42) Földi M, Csillik B, Zoltán ÖT:Lymphatic drainage of the brain. Experientia 24:1283-1287, 1968
43) Földi M, Gellért A, Kozma M, Poberai M, Zoltán OT, Csanda E:New contributions to the anatomical connections of the brain and the lymphatic system. Acta Anat(Basel)64:498-505, 1966
44) Gomez DG, Chambers AA, Di Benedetto AT, Potts DG:The spinal cerebrospinal fluid absorptive pathways. Neuroradiology 8:61-66, 1974
45) Gomez DG, Manzo RP, Fenstermacher JD, Potts DG:Cerebrospinal fluid absorption in the rabbit. Optic pathways. Graefes Arch Clin Exp Ophthalmol 226:1-7, 1988
46) Greitz T, Hindmarsh T:Computer assisted tomography of intracranial CSF circulation using a water-soluble contrast medium. Acta Radiol Diagn(Stockh)15:497-507, 1974
47) Hadaczek P, Yamashita Y, Mirek H, Tamas L, Bohn MC, Noble C, Park JW, Bankiewicz K:The “perivascular pump” driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain. Mol Ther 14:69-78, 2006
48) Haller Av:Primae lineae physiologiae in usum praelectionum academicarum. A. Vandenhoeck, Gottingae, 1747
49) Hammock MK, Milhorat TH, Davis DA:Isotope cisternography and ventriculography in the diagnosis of hydrocephalus. Dev Med Child Neurol 16:58-71, 1974
50) Hassin GB:Circulation of cerebrospinal fluid. J Nerv Ment Dis 79:465, 1934
51) Hassin GB:The cerebrospinal fluid pathways(a critical note). J Neuropathol Exp Neurol 6:172-176, 1947
52) Hasuo M, Asano Y, Teraoka M, Ikeyama A, Kageyama N:Cerebrospinal fluid absorption into the lymphatic system in increased intracranial pressure. In Ishii S, Nagai H, Brock M(eds):Intracranial Pressure V. Springer Verlag, Berlin, 1983, pp.611-617
53) Hayashi N, Matsumae M, Yatsushiro S, Hirayama A, Abdullah A, Kuroda K:Quantitative analysis of cerebrospinal fluid pressure gradients in healthy volunteers and patients with normal pressure hydrocephalus. Neurol Med Chir(Tokyo)55:657-662, 2015
54) Herndon RM, Brumback RA(eds):The Cerebrospinal Fluid. Kluwer Academic Publishers, Boston, 1989
55) Hettiarachchi HD, Hsu Y, Harris TJ Jr, Penn R, Linninger AA:The effect of pulsatile flow on intrathecal drug delivery in the spinal canal. Ann Biomed Eng 39:2592-2602, 2011
56) Hirayama A, Matsumae M, Yatsushiro S, Abdulla A, Atsumi H, Kuroda K:Visualization of pulsatile CSF motion around membrane-like structures with both 4D velocity mapping and Time-SLIP technique. Magn Reson Med Sci 14:263-273, 2015
57) Hladky SB, Barrand MA:Mechanisms of fluid movement into, through and out of the brain:evaluation of the evidence. Fluids Barriers CNS 11:26, 2014
58) Hutchings M, Weller RO:Anatomical relationships of the pia mater to cerebral blood vessels in man. J Neurosurg 65:316-325, 1986
59) Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M:A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med 4:147ra111, 2012
60) Johanson CE, Duncan JA 3rd, Klinge PM, Brinker T, Stopa EG, Silverberg GD:Multiplicity of cerebrospinal fluid functions:new challenges in health and disease. Cerebrospinal Fluid Res 5:10, 2008
61) Johnston M, Zakharov A, Papaiconomou C, Salmasi G, Armstrong D:Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species. Cerebrospinal Fluid Research 1:2, 2004
62) Kelly EJ, Yamada S:Cerebrospinal fluid flow studies and recent advancements. Semin Ultrasound CT MR 37:92-99, 2016
63) Key A, Retzius G:Studien in der Anatomie des Nervensystems und des Bindegewebes. Norstedt & Söner, Stockholm, 1875
64) Key A, Retzius G:Studien in der Anatomie des Nervensystems und des Bindegewebes. Norstedt & Söner, Stockholm, 1876
65) Kuriyama N, Yamada K, Sakai K, Tokuda T, Akazawa K, Tomii Y, Tamura A, Kondo M, Watanabe I, Ozaki E, Matsui D, Nakagawa M, Mizuno T, Watanabe Y:Ventricular temperatures in idiopathic normal pressure hydrocephalus(iNPH)measured with DWI-based MR thermometry. Magn Reson Med Sci 14:305-312, 2015
66) Lesch JE:Science and Medicine in France:the emergence of experimental physiology, 1790-1855. Harvard University Press, Cambridge, 1984, pp.178-191
67) Lim ST, Potts G, Deck MD:Changes in the ventricular size during fractional pneumoencephalography. Radiology 104:585-592, 1972
68) Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J:Structural and functional features of central nervous system lymphatic vessels. Nature 523:337-341, 2015
69) Love JA, Leslie RA:The effects of raised ICP on lymph flow in the cervical lymphatic trunks in cats. J Neurosurg 60:577-581, 1984
70) Magendie F:Recherches physiologiques et cliniques sur le liquide céphalo-rachidien ou cérébro-spinal. Méquignon-Marvis fils, Paris, 1842
71) Manzo RP, Gomez DG, Potts DG:Cerebrospinal fluid absorption in the rabbit. Inner ear pathways. Acta Otolaryngol 109:389-396, 1990
72) Mascagni P:Vasorum lymphaticorum corporis humani historia et ichnographia. Pazzini Carli, Senis, 1787
73) Matsumae M, Kikinis R, Mórocz I, Lorenzo AV, Albert MS, Black PM, Jolesz FA:Intracranial compartment volumes in patients with enlarged ventricles assessed by magnetic resonance-based image processing. J Neurosurg 84:972-981, 1996
74) Matsumae M, Hirayama A, Atsumi H, Yatsushiro S, Kuroda K:Velocity and pressure gradients of cerebrospinal fluid assessed with magnetic resonance imaging. J Neurosurg 120:218-227, 2014
75) Matsumae M, Sato O, Hirayama A, Hayashi N, Takizawa K, Atsumi H, Sorimachi T:Research into the physiology of cerebrospinal fluid reaches a new horizon:intimate exchange between cerebrospinal fluid and interstitial fluid may contribute to maintenance of homeostasis in the central nervous system. Neurol Med Chir(Tokyo)56:416-441, 2016
76) McComb JG, Hyman S, Weiss MH:Lymphatic drainage of cerebrospinal fluid in the cat. In Shapiro K, Marmarou A, Portnoy H(eds):Hydrocephalus. Raven Press, New York, 1984, pp.83-98
77) Miyazaki M, Sugiura S, Tateishi F, Wada H, Kassai Y, Abe H:Non-contrast-enhanced MR angiography using 3D ECG-synchronized half-Fourier fast spin echo. J Magn Reson Imaging 12:776-783, 2000
78) Nattie EE, Edwards WH:Brain and CSF water and ions in newborn puppies during acute hypo-and hypernatremia. J Appl Physiol Respir Environ Exerc Physiol 51:1086-1091, 1981
79) Orešković D, Klarica M:The formation of cerebrospinal fluid:nearly a hundred years of interpretations and misinterpretations. Brain Res Rev 64:241-262, 2010
80) Preston SD, Steart PV, Wilkinson A, Nicoll JA, Weller RO:Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease:defining the perivascular route for the elimination of amyloid beta from the human brain. Neuropathol Appl Neurobiol 29:106-117, 2003
81) Robin C:Recherches sur quelques particularités de la structure des capillaires de l'encéphale. J Physiol Homme 2:537-548, 1859
82) Rottenberg DA, Howieson J, Deck MD:The rate of CSF formation in man:preliminary observations on metrizamide washout as a measure of CSF bulk flow. Ann Neurol 2:503-510, 1977
83) Sato O, Asai T, Amano Y, Hara M, Tsugane R, Yagi M:Extraventricular origin of the cerebrospinal fluid:formation rate quantitatively measured in the spinal subarachnoid space of dogs. J Neurosurg 36:276-282, 1972
84) 佐藤 修:脳脊髄液研究再考.新井 一(監),石川正恒,森 悦朗(編):特発性正常圧水頭症の診療.金芳堂,京都,2014, pp.8-18
85) Schläger C, Körner H, Krueger M, Vidoli S, Haberl M, Mielke D, Brylla E, Issekutz T, Cabañas C, Nelson PJ, Ziemssen T, Rohde V, Bechmann I, Lodygin D, Odoardi F, Flügel A:Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid. Nature 530:349-353, 2016
86) Selverstone B:Studies of the formation and absorption of the cerebrospinal fluid using radioactive isotopes:a critical evaluation of data and conclusions. In Wolstenholme GEW, O'connor CM(eds):Ciba Foundation Symposium-The Cerebrospinal Fluid:Production, Circulation and Absorption. John Wiley & Sons Ltd., Chichester, 1958, pp.147-167
87) Sierra Del Rio M, Ricard D, Houillier C, Navarro S, Gonzalez-Aguilar A, Idbaih A, Kaloshi G, Elhallani S, Omuro A, Choquet S, Soussain C, Hoang-Xuan K:Prophylactic intrathecal chemotherapy in primary CNS lymphoma. J Neurooncol 106:143-146, 2012
88) Suzuki Y, Nakamura Y, Yamada K, Igarashi H, Kasuga K, Yokoyama Y, Ikeuchi T, Nishizawa M, Kwee IL, Nakada T:Reduced CSF water influx in Alzheimer's disease supporting the β-amyloid clearance hypothesis. PLoS One 10:e0123708, 2015
89) Tamaki N, Kanazawa Y, Asada M, Kusunoki T, Matsumoto S:Dynamics of cerebrospinal fluid circulation evaluated by metrizamide CT cisternography. J Comput Assist Tomogr 3:209-216, 1979
90) Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H, Nicholson C, Zlokovic BV, Frangione B, Blennow K, Ménard J, Zetterberg H, Wisniewski T, de Leon MJ:Clearance systems in the brain-implications for Alzheimer disease. Nat Rev Neurol 11:457-470, 2015
91) Tripathi RC:The functional morphology of the outflow systems of ocular and cerebrospinal fluids. Exp Eye Res 25 Suppl:65-116, 1977
92) Tubbs RS, Hansasuta A, Stetler W, Kelly DR, Blevins D, Humphrey R, Chua GD, Shoja MM, Loukas M, Oakes WJ:Human spinal arachnoid villi revisited:immunohistological study and review of the literature. J Neurosurg Spine 7:328-331, 2007
93) Viets HR:Domenico Cotugno:His description of the cerebrospinal fluid, with a translation of part of his De Ischiade Nervosa Commentarius(1764)and a bibliography of his important works. Bulletin of the Institute of the history of medicine-The Johns Hopkins University 3:701-713, 1935
94) Virchow R:Ueber die Erweiterung kleinerer Gefäfse. Arch Pathol Anat Physiol Klin Med 3:427-462, 1851
95) Wang P, Olbricht WL:Fluid mechanics in the perivascular space. J Theor Biol 274:52-57, 2011
96) Weller RO, Mitchell J:Cerebrospinal fluid edema and its sequelae in hydrocephalus. Adv Neurol 28:111-123, 1980
97) Weller RO, Kida S, Harding BN:Aetiology and pathology of hydrocephalus. In Schurr PH, Polkey CE(eds):Hydrocephalus. Oxford University Press, Oxford, 1993, pp.48-99
98) Weller RO, Galea I, Carare RO, Minagar A:Pathophysiology of the lymphatic drainage of the central nervous system:implications for pathogenesis and therapy of multiple sclerosis. Pathophysiology 17:295-306, 2010
99) Wislocki GB, Putnam TJ:Absorption from the ventricles in experimentally produced internal hydrocephalus. Am J Anat 29:313-320, 1921
100)Yamada S, Miyazaki M, Kanazawa H, Higashi M, Morohoshi Y, Bluml S, McComb JG:Visualization of cerebrospinal fluid movement with spin labeling at MR imaging:preliminary results in normal and pathophysiologic conditions. Radiology 249:644-652, 2008
101)Yamada S, Miyazaki M, Yamashita Y, Ouyang C, Yui M, Nakahashi M, Shimizu S, Aoki I, Morohoshi Y, McComb JG:Influence of respiration on cerebrospinal fluid movement using magnetic resonance spin labeling. Fluids Barriers CNS 10:36, 2013
102)Yamada S, Tsuchiya K, Bradley WG, Law M, Winkler ML, Borzage MT, Miyazaki M, Kelly EJ, McComb JG:Current and emerging MR imaging techniques for the diagnosis and management of CSF flow disorders:a review of phase-contrast and time-spatial labeling inversion pulse. AJNR Am J Neuroradiol 36:623-630, 2015
103)Yang L, Kress BT, Weber HJ, Thiyagarajan M, Wang B, Deane R, Benveniste H, Iliff JJ, Nedergaard M:Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer. J Transl Med 11:107, 2013
104)Yatsushiro S, Hirayama A, Matsumae M, Kuroda K:Visualization of pulsatile CSF motion separated by membrane-like structure based on four-dimensional phase-contrast(4D-PC)velocity mapping. Conf Proc IEEE Eng Med Biol Soc 2013:6470-6473, 2013

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1251

印刷版ISSN:0301-2603

雑誌購入ページに移動
icon up
あなたは医療従事者ですか?