Neurological Surgery 脳神経外科45巻2号

2017年02月発行

症例

乳児atypical teratoid/rhabdoid tumorに対する放射線治療および分子生物学的分類と予後との関連について

著者： 大谷理浩¹ 市川智継¹ 黒住和彦¹ 安原隆雄¹ 鷲尾佳奈² 嶋田明² 片山敬久³ 勝井邦彰⁴ 柳井広之⁵ 伊達勲¹

所属機関： ¹岡山大学大学院医歯薬学総合研究科脳神経外科学 ²岡山大学大学院医歯薬学総合研究科小児医科学 ³岡山大学大学院医歯薬学総合研究科放射線医学 ⁴岡山大学大学院医歯薬学総合研究科陽子線治療学 ⁵岡山大学病院病理診断科

ページ範囲：P.147 - P.154

Ⅰ．はじめに
　Atypical teratoid/rhabdoid tumor（AT/RT）は，1995年にRorkeらにより提唱され，WHO2000に新しい腫瘍概念として採用された胎児性腫瘍である¹²⁾．希少な腫瘍のため定まった治療方針はなく，手術や化学療法を行った場合でも3年生存率は約10%と非常に予後不良な疾患である¹⁷⁾．これまで3歳未満の患児では放射線治療は行っていない報告が主であったが，生命予後が極めて不良であったため，近年では3歳未満でも放射線治療を行った報告が散見される．今回われわれは，当院で治療を行った乳児AT/RTの4例について，放射線治療の有無および近年報告されている分子生物学的所見に基づく分類について，予後との関連を検討した．

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