icon fsr

文献詳細

雑誌文献

Neurological Surgery 脳神経外科45巻8号

2017年08月発行

文献概要

連載 脳神経外科診療に役立つPETによる診断法【新連載】

(1)脳神経領域におけるPETの特徴

著者: 飯田秀博1 井口智史1 山内美穂1 越野一博2 安野史彦3 福田哲也1

所属機関: 1国立循環器病研究センター放射線部 2国立循環器病研究センター研究所画像診断医学部 3奈良県立医科大学精神科

ページ範囲:P.723 - P.736

文献購入ページに移動
Ⅰ.はじめに
 ポジトロン放出核種を使った生体の断層撮像(positron emission tomography:PET)における技術開発は,放射性同位元素の製造と標識合成技術,放射線計測技術や画像再構成法,さらに高度な画像解析法の開発などの,多分野の研究者と医学者との協力のもとに実用化がなされてきた.PETは,現在の多様な医療の中で,不可欠な診断技術と位置付けられており,分野横断的なコラボレーションに支えられながら,さらなる技術革新が進んでいるところである.本稿では,PETを使った種々の脳機能画像がどのように開発されてきたかを振り返り,そこからPETの新たな可能性を探るとともに,今後のあり方についても言及したい.

参考文献

1) Baron JC, Jones T:Oxygen metabolism, oxygen extraction and positron emission tomography:historical perspective and impact on basic and clinical neuroscience. Neuroimage 61:492-504, 2012
module for imaging the peripheral benzodiazepine receptor with PET. Appl Radiat Isot 70:176-183, 2012
C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo. J Med Chem 51:17-30, 2008
4) Burke JF, Albin RL, Koeppe RA, Giordani B, Kilbourn MR, Gilman S, Frey KA:Assessment of mild dementia with amyloid and dopamine terminal positron emission tomography. Brain 134(Pt 6):1647-1657, 2011
C. Eur J Nucl Med 1:11-14, 1976
6) Furukawa K, Okamura N, Tashiro M, Waragai M, Furumoto S, Iwata R, Yanai K, Kudo Y, Arai H:Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227:comparison to FDG-PET. J Neurol 257:721-727, 2010
F-labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography. Mol Imaging Biol 15:497-506, 2013
8) Garnett ES, Firnau G, Nahmias C:Dopamine visualized in the basal ganglia of living man. Nature 305(5930):137-138, 1983
F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med 27:235-238, 1986
O-labeled oxygen for quantitative assessment of regional metabolic rate of oxygen in man. Phys Med Biol 59:5593-5609, 2014
11) Hübner KF, Andrews GA, Buonocore E, Hayes RL, Washburn LC, Collmann IR, Gibbs WD:Carbon-11-labeled amino acids for the rectilinear and positron tomographic imaging of the human pancreas. J Nucl Med 20:507-513, 1979
C-2-deoxy-2-fluoro-D-glucose. J Labelled Comp Radiopharm 14:175-183, 1978
O-labeled gaseous PET. Nucl Instrum Methods Phys Res A 702:111-113, 2013
14) Iida H, Jones T, Miura S:Modeling approach to eliminate the need to separate arterial plasma in oxygen-15 inhalation positron emission tomography. J Nucl Med 34:1333-1340, 1993
O-labeled oxyhemoglobin on Macaca fascicularis. J Cereb Blood Flow Metab 34:1434-1439, 2014
F]-fluorophenylalanine and PET. J Nucl Med 36:1232-1237, 1995
17) Jack CR Jr, Wiste HJ, Vemuri P, Weigand SD, Senjem ML, Zeng G, Bernstein MA, Gunter JL, Pankratz VS, Aisen PS, Weiner MW, Petersen RC, Shaw LM, Trojanowski JQ, Knopman DS;Alzheimer's Disease Neuroimaging Initiative:Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease. Brain 133:3336-3348, 2010
18) Jones T, Rabiner EA;PET Research Advisory Company:The development, past achievements, and future directions of brain PET. J Cereb Blood Flow Metab 32:1426-1454, 2012
19) Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergström M, Savitcheva I, Huang GF, Estrada S, Ausén B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Långström B:Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol 55:306-319, 2004
inhalation PET. J Cereb Blood Flow Metab 29:355-364, 2009
21) Ogawa T, Miura S, Murakami M, Iida H, Hatazawa J, Inugami A, Kanno I, Yasui N, Sasajima T, Uemura K:Quantitative evaluation of neutral amino acid transport in cerebral gliomas using positron emission tomography and fluorine-18 fluorophenylalanine. Eur J Nucl Med 23:889-895, 1996
F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease. J Nucl Med 54:1420-1427, 2013
C-PIB PET study. Neurology 73:754-760, 2009
24) Powers WJ, Martin WR, Herscovitch P, Raichle ME, Grubb RL Jr:Extracranial-intracranial bypass surgery:hemodynamic and metabolic effects. Neurology 34:1168-1174, 1984
C psychotropic drugs in man. Dynamic studies with radioisotopes in medicine. vol SM 185/84:International Atomic Energy Agency, 1974, pp45-56
C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab:a phase 2, double-blind, placebo-controlled, ascending-dose study. Lancet Neurol 9:363-372, 2010
C]deoxyglucose method for the measurement of local cerebral glucose utilization:theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28:897-916, 1977
28) Teuho J, Johansson J, Linden J, Hansen AE, Holm S, Keller SH, Delso G, Veit-Haibach P, Magota K, Saunavaara V, Tolvanen T, Teräs M, Iida H:Effect of attenuation correction on regional quantification between PET/MR and PET/CT:a multicenter study using a 3-dimensional brain phantom. J Nucl Med 57:818-824, 2016
29) Vaishnavi SN, Vlassenko AG, Rundle MM, Snyder AZ, Mintun MA, Raichle ME:Regional aerobic glycolysis in the human brain. Proc Natl Acad Sci U S A 107:17757-17762, 2010
30) Vlassenko AG, Vaishnavi SN, Couture L, Sacco D, Shannon BJ, Mach RH, Morris JC, Raichle ME, Mintun MA:Spatial correlation between brain aerobic glycolysis and amyloid-β(Aβ)deposition. Proc Natl Acad Sci U S A 107:17763-17767, 2010
31) Vlassenko AG, Raichle ME:Brain aerobic glycolysis functions and Alzheimer's disease. Clin Transl Imaging 3:27-37, 2015
32) Vlassenko AG, McConathy J, Couture LE, Su Y, Massoumzadeh P, Leeds HS, Chicoine MR, Tran DD, Huang J, Dahiya S, Marcus DS, Fouke SJ, Rich KM, Raichle ME, Benzinger TL:Aerobic glycolysis as a marker of tumor aggressiveness:preliminary data in high grade human brain tumors. Dis Markers 2015:874904, 2015
33) Wagner HN Jr, Burns HD, Dannals RF, Wong DF, Langstrom B, Duelfer T, Frost JJ, Ravert HT, Links JM, Rosenbloom SB, Lukas SE, Kramer AV, Kuhar MJ:Imaging dopamine receptors in the human brain by positron tomography. Science 221(4617):1264-1266, 1983
34) Wolk DA, Price JC, Saxton JA, Snitz BE, James JA, Lopez OL, Aizenstein HJ, Cohen AD, Weissfeld LA, Mathis CA, Klunk WE, De-Kosky ST:Amyloid imaging in mild cognitive impairment subtypes. Ann Neurol 65:557-568, 2009

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1251

印刷版ISSN:0301-2603

雑誌購入ページに移動
icon up
あなたは医療従事者ですか?