文献詳細
文献概要
総説
特発性正常圧水頭症のトピックス—超高齢社会への適応に向けたガイドライン改訂の要点
著者: 山田茂樹1
所属機関: 1滋賀医科大学脳神経外科学講座
ページ範囲:P.773 - P.780
文献購入ページに移動Ⅰ.序論
この20年で高齢化率が倍増し,介護提供者の不足が大きな問題となりつつあるわが国において,介護が必要となる3大要因「歩けない」「物忘れ」「尿失禁」を主症状とする特発性正常圧水頭症(idiopathic normal pressure hydrocephalus:iNPH)は,脳神経外科医にとって慢性硬膜下血腫とならび身近で診療する機会の多い疾患である.
しかしながら,慢性硬膜下血腫の穿頭血腫除去術とは異なり,症状が進行してから髄液シャント手術を行っても介護が必要なくなるほどまでの回復は困難であり,早期発見と適切な時期に手術を勧めることが重要である.ただしiNPH患者は,転倒リスクが高いために入院中に日常生活動作が制限されやすく,手術にはさまざまなピットフォールがあり,万が一にも合併症を来すと,容易に歩行・認知機能の低下に陥る.またシャント術後も,バルブの設定圧を適宜変更して髄液排出量を適正に調整し,積極的なリハビリテーションを行い,退院後も長期的に患者とその家族に寄り添う医療が求められる.
この20年で高齢化率が倍増し,介護提供者の不足が大きな問題となりつつあるわが国において,介護が必要となる3大要因「歩けない」「物忘れ」「尿失禁」を主症状とする特発性正常圧水頭症(idiopathic normal pressure hydrocephalus:iNPH)は,脳神経外科医にとって慢性硬膜下血腫とならび身近で診療する機会の多い疾患である.
しかしながら,慢性硬膜下血腫の穿頭血腫除去術とは異なり,症状が進行してから髄液シャント手術を行っても介護が必要なくなるほどまでの回復は困難であり,早期発見と適切な時期に手術を勧めることが重要である.ただしiNPH患者は,転倒リスクが高いために入院中に日常生活動作が制限されやすく,手術にはさまざまなピットフォールがあり,万が一にも合併症を来すと,容易に歩行・認知機能の低下に陥る.またシャント術後も,バルブの設定圧を適宜変更して髄液排出量を適正に調整し,積極的なリハビリテーションを行い,退院後も長期的に患者とその家族に寄り添う医療が求められる.
参考文献
1) Ambarki K, Israelsson H, Wåhlin A, Birgander R, Eklund A, Malm J:Brain ventricular size in healthy elderly:comparison between Evans index and volume measurement. Neurosurgery 67:94-99, 2010
2) Bradley WG Jr, Bahl G, Alksne JF:Idiopathic normal pressure hydrocephalus may be a “two hit” disease:benign external hydrocephalus in infancy followed by deep white matter ischemia in late adulthood. J Magn Reson Imaging 24:747-755, 2006
3) Chan AK, McGovern RA, Zacharia BE, Mikell CB, Bruce SS, Sheehy JP, Kelly KM, McKhann GM 2nd:Inferior short-term safety profile of endoscopic third ventriculostomy compared with ventriculoperitoneal shunt placement for idiopathic normal-pressure hydrocephalus:a population-based study. Neurosurgery 73:951-961, 2013
4) Graff-Radford NR, Godersky JC:Symptomatic congenital hydrocephalus in the elderly simulating normal pressure hydrocephalus. Neurology 39:1596-1600, 1989
5) Hakim S, Adams RD:The special clinical problem of symptomatic hydrocephalus with normal cerebrospinal fluid pressure. Observations on cerebrospinal fluid hydrodynamics. J Neurol Sci 2:307-327, 1965
6) Hashimoto M, Ishikawa M, Mori E, Kuwana N;Study of INPH on neurological improvement(SINPHONI):Diagnosis of idiopathic normal pressure hydrocephalus is supported by MRI-based scheme:a prospective cohort study. Cerebrospinal Fluid Res 7:18, 2010
7) Hung AL, Vivas-Buitrago T, Adam A, Lu J, Robison J, Elder BD, Goodwin CR, Jusué-Torres I, Rigamonti D:Ventriculoatrial versus ventriculoperitoneal shunt complications in idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg 157:1-6, 2017
8) Ishikawa M;Guideline Committee for Idiopathic Normal Pressure Hydrocephalus, Japanese Society of Normal Pressure Hydrocephalus:Clinical guidelines for idiopathic normal pressure hydrocephalus. Neurol Med Chir(Tokyo)44:222-223, 2004
9) Kameda M, Yamada S, Atsuchi M, Kimura T, Kazui H, Miyajima M, Mori E, Ishikawa M, Date I, SINPHONI and SINPHONI-2 Investigators:Cost-effectiveness analysis of shunt surgery for idiopathic normal pressure hydrocephalus based on the SINPHONI and SINPHONI-2 trials. Acta Neuroch ir(Wien)159:995-1003, 2017
10) Kanemoto H, Kazui H, Suzuki Y, Sato S, Kishima H, Yoshimine T, Yoshiyama K:Effect of lumbo-peritoneal shunt surgery on neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus. J Neurol Sci 361:206-212, 2016
11) Kazui H, Miyajima M, Mori E, Ishikawa M;SINPHONI-2 Investigators:Lumboperitoneal shunt surgery for idiopathic normal pressure hydrocephalus(SINPHONI-2):an open-label randomised trial. Lancet Neurol 14:585-594, 2015
12) Meier U, Mutze S:Correlation between decreased ventricular size and positive clinical outcome following shunt placement in patients with normal-pressure hydrocephalus. J Neurosurg 100:1036-1040, 2004
13) Miyajima M, Kazui H, Mori E, Ishikawa M;on behalf of the SINPHONI-2 Investigators:One-year outcome in patients with idiopathic normal-pressure hydrocephalus:comparison of lumboperitoneal shunt to ventriculoperitoneal shunt. J Neurosurg 125:1483-1492, 2016
14) Mori E, Ishikawa M, Kato T, Kazui H, Miyake H, Miyajima M, Nakajima M, Hashimoto M, Kuriyama N, Tokuda T, Ishii K, Kaijima M, Hirata Y, Saito M, Arai H, Japanese Society of Normal Pressure Hydrocephalus:Guidelines for management of idiopathic normal pressure hydrocephalus:second edition. Neurol Med Chir(Tokyo)52:775-809, 2012
15) Nakajima M, Miyajima M, Ogino I, Akiba C, Kawamura K, Kamohara C, Fusegi K, Harada Y, Hara T, Sugano H, Tange Y, Karagiozov K, Kasuga K, Ikeuchi T, Tokuda T, Arai H:Preoperative phosphorylated Tau concentration in the cerebrospinal fluid can predict cognitive function three years after shunt surgery in patients with idiopathic normal pressure hydrocephalus. J Alzheimers Dis 66:319-331, 2018
16) Nesvick CL, Khan NR, Mehta GU, Klimo P Jr:Image guidance in ventricular cerebrospinal fluid shunt catheter placement:a systematic review and meta-analysis. Neurosurgery 77:321-331, 2015
17) 日本正常圧水頭症学会 特発性正常圧水頭症診療ガイドライン作成委員会:特発性正常圧水頭症診療ガイドライン 第2版.メディカルレビュー社,大阪,2011
18) 日本正常圧水頭症学会「特発性正常圧水頭症の診療ガイドライン作成に関する研究」班:特発性正常圧水頭症診療ガイドライン 第3版.メディカルレビュー社,大阪,2020
19) 日本正常圧水頭症研究会 特発性正常圧水頭症診療ガイドライン作成委員会:特発性正常圧水頭症診療ガイドライン(初版).メディカルレビュー社,大阪,2004
20) Relkin N, Marmarou A, Klinge P, Bergsneider M, Black PM:Diagnosing idiopathic normal-pressure hydrocephalus. Neurosurgery 57(3 Suppl):S4-S16;discussion ii-v, 2005
21) Saper CB:The Emperor has no clothes. Ann Neurol 79:165-166, 2016
22) Schniepp R, Trabold R, Romagna A, Akrami F, Hesselbarth K, Wuehr M, Peraud A, Brandt T, Dieterich M, Jahn K:Walking assessment after lumbar puncture in normal-pressure hydrocephalus:a delayed improvement over 3 days. J Neurosurg 126:148-157, 2017
23) Toma AK, Holl E, Kitchen ND, Watkins LD:Evans' index revisited:the need for an alternative in normal pressure hydrocephalus. Neurosurgery 68:939-944, 2011
24) Yamada S, Ishikawa M, Yamamoto K:Optimal diagnostic indices for idiopathic normal pressure hydrocephalus based on the 3D quantitative volumetric analysis for the cerebral ventricle and subarachnoid space. AJNR Am J Neuroradiol 36:2262-2269, 2015
25) Yamada S, Ishikawa M, Yamamoto K:Comparison of CSF distribution between idiopathic normal pressure hydrocephalus and Alzheimer disease. AJNR Am J Neuroradiol 37:1249-1255, 2016
26) Yamada S, Ishikawa M, Iwamuro Y, Yamamoto K:Choroidal fissure acts as an overflow device in cerebrospinal fluid drainage:morphological comparison between idiopathic and secondary normal-pressure hydrocephalus. Sci Rep 6:39070, 2016
27) Yamada S, Ishikawa M, Miyajima M, Atsuchi M, Kimura T, Kazui H, Mori E, SINPHONI-2 Investigators(Appendix):Disease duration:the key to accurate CSF tap test in iNPH. Acta Neurol Scand 135:189-196, 2017
28) Yamada S, Ishikawa M, Miyajima M, Nakajima M, Atsuchi M, Kimura T, Tokuda T, Kazui H, Mori E:Timed up and go test at tap test and shunt surgery in idiopathic normal pressure hydrocephalus. Neurol Clin Pract 7:98-108, 2017
29) Yamada S, Kimura T, Jingami N, Atsuchi M, Hirai O, Tokuda T, Miyajima M, Kazui H, Mori E, Ishikawa M, SINPHONI-2 Investigators:Disability risk or unimproved symptoms following shunt surgery in patients with idiopathic normal-pressure hydrocephalus:post hoc analysis of SINPHONI-2. J Neurosurg 126:2002-2009, 2017
30) Yamada S, Aoyagi Y, Yamamoto K, Ishikawa M:Quantitative evaluation of gait disturbance on an instrumented timed up-and-go test. Aging Dis 10:23-36, 2019
31) Yamada S, Ishikawa M, Yamamoto K:Utility of preoperative simulation for ventricular catheter placement via a parieto-occipital approach in normal-pressure hydrocephalus. Oper Neurosurg(Hagerstown)16:647-657, 2019
掲載誌情報