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Neurological Surgery 脳神経外科49巻3号

2021年05月発行

文献概要

特集 グリオーマ—現在の常識と近未来のスタンダード Ⅳグリオーマ治療法update

化学療法

著者: 齋藤竜太1

所属機関: 1名古屋大学大学院医学系研究科脳神経外科学

ページ範囲:P.588 - P.596

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・全身化学療法において,血液脳関門により化学療法薬の脳腫瘍内集積は制限される.
・カルムスチン脳内留置用剤は,局所高濃度化学療法を達するが浸透性に限界がある.
・脳腫瘍への化学療法は,有効性向上に向けた研究が必要とされる分野である.

参考文献

1)Saito R, et al:Two different mechanisms of apoptosis resistance observed in interferon-beta induced apoptosis of human glioma cells. J Neurooncol 67:273-280, 2004
2)Stupp R, et al:Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987-996, 2005
3)Stevens MF, et al:Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one(CCRG 81045;M & B 39831), a novel drug with potential as an alternative to dacarbazine. Cancer Res 47:5846-5852, 1987
4)Aoki T, et al:Pharmacokinetic study of temozolomide on a daily-for-5-days schedule in Japanese patients with relapsed malignant gliomas:first study in Asians. Int J Clin Oncol 12:341-349, 2007
5)西川 亮,他:初回再発の退形成性星細胞腫患者に対するTemozolomide単剤投与の有効性および安全性の検討—多施設共同第Ⅱ相試験.癌と化学療法 33:1279-1285, 2006
6)Shoji T, et al:Hepatitis B virus reactivation during temozolomide administration for malignant glioma. Int J Clin Oncol 26:305-315, 2021
7)Hegi ME, et al:MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352:997-1003, 2005
8)三木俊一郎,他:グリオーマ遺伝子検査の理解の基本とpitfall.脳外誌 26:806-816, 2017
9)Walker MD, et al:Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med 303:1323-1329, 1980
10)Juillerat-Jeanneret L:The targeted delivery of cancer drugs across the blood-brain barrier:chemical modifications of drugs or drug-nanoparticles? Drug Discovery Today 13:1099-1106, 2008
11)Brem H, et al:Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas. J Neurosurg 74:441-446, 1991
12)Brem H, et al:Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. The Polymer-brain Tumor Treatment Group. Lancet 345(8956):1008-1012, 1995
13)Westphal M, et al:A phase 3 trial of local chemotherapy with biodegradable carmustine(BCNU)wafers(Gliadel wafers)in patients with primary malignant glioma. Neuro Oncol 5:79-88, 2003
wafer)for Japanese patients with malignant gliomas. Neurol Med Chir(Tokyo)54:290-301, 2014
15)Kadota T, et al:A multicenter randomized phase Ⅲ study for newly diagnosed maximally resected glioblastoma comparing carmustine wafer implantation followed by chemoradiotherapy with temozolomide with chemoradiotherapy alone;Japan Clinical Oncology Group Study JCOG1703(MACS study). Jpn J Clin Oncol 49:1172-1175, 2019
16)Saito R, et al:Regression of recurrent glioblastoma infiltrating the brainstem after convection-enhanced delivery of nimustine hydrochloride. J Neurosurg Pediatr 7:522-526, 2011
17)Saito R, et al:Phase Ⅰ trial of convection-enhanced delivery of nimustine hydrochloride(ACNU)for brainstem recurrent glioma. Neurooncol Adv 2:vdaa033, 2020

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1251

印刷版ISSN:0301-2603

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