1)Ostrom QT, et al:CBTRUS statistical report:primary brain and other central nervous system tumors diagnosed in the United States in 2013-2017. Neuro Oncol 22(12 Suppl 2):iv1-iv96, 2020
2)Stupp R, et al;European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups;National Cancer Institute of Canada Clinical Trials Group:Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987-996, 2005
3)Stupp R, et al;European Organisation for Research and Treatment of Cancer Brain Tumour and Radiation Oncology Groups;National Cancer Institute of Canada Clinical Trials Group:Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase Ⅲ study:5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10:459-466, 2009
4)Stupp R, et al:Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma:a randomized clinical trial. JAMA 318:2306-2316, 2017
5)Reardon DA, et al:Effect of nivolumab vs bevacizumab in patients with recurrent glioblastoma:the CheckMate 143 phase 3 randomized clinical trial. JAMA Oncol 6:1003-1010, 2020
6)Vuorinen V, et al:Debulking or biopsy of malignant glioma in elderly people - a randomised study. Acta Neurochir(Wien)145:5-10, 2003
7)Lacroix M, et al:A multivariate analysis of 416 patients with glioblastoma multiforme:prognosis, extent of resection, and survival. J Neurosurg 95:190-198, 2001
8)Stummer W, et al;ALA-Glioma Study Group:Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma:a randomised controlled multicentre phase Ⅲ trial. Lancet Oncol 7:392-401, 2006
9)Sanai N, et al:An extent of resection threshold for newly diagnosed glioblastomas. J Neurosurg 115:3-8, 2011
10)Brown TJ, et al:Association of the extent of resection with survival in glioblastoma:a systematic review and meta-analysis. JAMA Oncol 2:1460-1469, 2016
11)Marko NF, et al:Extent of resection of glioblastoma revisited:personalized survival modeling facilitates more accurate survival prediction and supports a maximum-safe-resection approach to surgery. J Clin Oncol 32:774-782, 2014
12)Ellingson BM, et al:Validation of postoperative residual contrast-enhancing tumor volume as an independent prognostic factor for overall survival in newly diagnosed glioblastoma. Neuro Oncol 20:1240-1250, 2018
13)Kreth FW, et al;German Glioma Network:Gross total but not incomplete resection of glioblastoma prolongs survival in the era of radiochemotherapy. Ann Oncol 24:3117-3123, 2013
14)Wen PY, et al:Glioblastoma in adults:a Society for Neuro-Oncology(SNO)and European Society of Neuro-Oncology(EANO)consensus review on current management and future directions. Neuro Oncol 22:1073-1113, 2020
15)McGirt MJ, et al:Association of surgically acquired motor and language deficits on overall survival after resection of glioblastoma multiforme. Neurosurgery 65:463-469;discussion 469-470, 2009
16)Hochberg FH, Pruitt A:Assumptions in the radiotherapy of glioblastoma. Neurology 30:907-911, 1980
17)Chang CH, et al:Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study. Cancer 52:997-1007, 1983
18)Roa W, et al:Abbreviated course of radiation therapy in older patients with glioblastoma multiforme:a prospective randomized clinical trial. J Clin Oncol 22:1583-1588, 2004
19)Roa W, et al:International Atomic Energy Agency randomized phase Ⅲ study of radiation therapy in elderly and/or frail patients with newly diagnosed glioblastoma multiforme. J Clin Oncol 33:4145-4150, 2015
20)Hermanto U, et al:Intensity-modulated radiotherapy(IMRT)and conventional three-dimensional conformal radiotherapy for high-grade gliomas:does IMRT increase the integral dose to normal brain? Int J Radiat Oncol Biol Phys 67:1135-1144, 2007
21)Amelio D, et al:Intensity-modulated radiation therapy in newly diagnosed glioblastoma:a systematic review on clinical and technical issues. Radiother Oncol 97:361-369, 2010
22)Balana C, et al:A phase Ⅱ randomized, multicenter, open-label trial of continuing adjuvant temozolomide beyond 6 cycles in patients with glioblastoma(GEINO 14-01). Neuro Oncol 22:1851-1861, 2020
23)Blumenthal DT, et al:Is more better? The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma:a secondary analysis of EORTC and NRG Oncology/RTOG. Neuro Oncol 19:1119-1126, 2017
24)Hegi ME, et al:MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352:997-1003, 2005
25)Esteller M, et al:Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343:1350-1354, 2000
26)Gilbert MR, et al:Dose-dense temozolomide for newly diagnosed glioblastoma:a randomized phase Ⅲ clinical trial. J Clin Oncol 31:4085-4091, 2013
27)Tanaka S, et al:Diagnostic and therapeutic avenues for glioblastoma:no longer a dead end? Nat Rev Clin Oncol 10:14-26, 2013
28)Chinot OL, et al:Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med 370:709-722, 2014
29)Gilbert MR, et al:A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med 370:699-708, 2014
30)Friedman HS, et al:Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol 27:4733-4740, 2009
31)Wick W, et al:Lomustine and bevacizumab in progressive glioblastoma. N Engl J Med 377:1954-1963, 2017
32)Westphal M, et al:A phase 3 trial of local chemotherapy with biodegradable carmustine(BCNU)wafers(Gliadel wafers)in patients with primary malignant glioma. Neuro Oncol 5:79-88, 2003
33)Wakabayashi T, et al;Members of Japan Clinical Oncology Group Brain Tumor Study Group(JCOG-BTSG):JCOG0911 INTEGRA study:a randomized screening phase Ⅱ trial of interferonβ plus temozolomide in comparison with temozolomide alone for newly diagnosed glioblastoma. J Neurooncol 138:627-636, 2018
system for glioblastoma:The Patient Registry Dataset(PRiDe). Semin Oncol 41 Suppl 6:S4-S13, 2014
35)Muragaki Y, et al:Phase Ⅱ clinical study on intraoperative photodynamic therapy with talaporfin sodium and semiconductor laser in patients with malignant brain tumors. J Neurosurg 119:845-852, 2013
36)van Breemen MS, et al:Epilepsy in patients with brain tumours:epidemiology, mechanisms, and management. Lancet Neurol 6:421-430, 2007
37)Wu AS, et al:A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors. J Neurosurg 118:873-883, 2013
38)Greenhalgh J, et al:Antiepileptic drugs as prophylaxis for postcraniotomy seizures. Cochrane Database Syst Rev 4:CD007286, 2020
39)Göttlicher M, et al:Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 20:6969-6978, 2001
40)Bobustuc GC, et al:Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide. Neuro Oncol 12:917-927, 2010
41)Happold C, et al:Does valproic acid or levetiracetam improve survival in glioblastoma? A pooled analysis of prospective clinical trials in newly diagnosed glioblastoma. J Clin Oncol 34:731-739, 2016
-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells. Nat Med 8:971-978, 2002
43)Lange F, et al:AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro. PLoS One 14:e0211644, 2019
44)Grossman SA, et al:Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma:a multicenter phase Ⅱ trial. J Clin Oncol 27:4155-4161, 2009
45)Venkatesh HS, et al:Neuronal activity promotes glioma growth through neuroligin-3 secretion. Cell 161:803-816, 2015
46)Venkatesh HS, et al:Electrical and synaptic integration of glioma into neural circuits. Nature 573(7775):539-545, 2019
47)Collins FS, Varmus H:A new initiative on precision medicine. N Engl J Med 372:793-795, 2015
48)Chi AS, et al:Exploring predictors of response to dacomitinib in EGFR-amplified recurrent glioblastoma. JCO Precis Oncol 4:PO.19.00295, 2020
49)Patel AP, et al:Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science 344(6190):1396-1401, 2014
50)Louis DN, et al:cIMPACT-NOW update 6:new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading. Brain Pathol 30:844-856, 2020
51)Konteatis Z, et al:Vorasidenib(AG-881):a first-in-class, brain-penetrant dual inhibitor of mutant IDH1 and 2 for treatment of glioma. ACS Med Chem Lett 11:101-107, 2020
52)Machida Y, et al:A potent blood-brain barrier-permeable mutant IDH1 inhibitor suppresses the growth of glioblastoma with IDH1 mutation in a patient-derived orthotopic xenograft model. Mol Cancer Ther 19:375-383, 2020
53)Johnson DR, O'Neill BP:Glioblastoma survival in the United States before and during the temozolomide era. J Neurooncol 107:359-364, 2012
54)Johnson DR, et al:Glioblastoma survival in the United States improved after Food and Drug Administration approval of bevacizumab:a population-based analysis. Cancer 119:3489-3495, 2013