文献詳細
文献概要
特集 頭部外傷診療アップデート—ガイドラインを読み解く Ⅲ さまざまな頭部外傷の病態
Talk and deteriorateと高齢者頭部外傷
著者: 刈部博1
所属機関: 1仙台市立病院脳神経外科
ページ範囲:P.1001 - P.1009
文献購入ページに移動Point
・高齢者頭部外傷は転帰不良であり,高齢者特有の身体能力の低下や解剖学的特徴,生理学的特徴に外傷リスクや悪化リスクがあると考えられている.
・Talk and deteriorateは高齢者頭部外傷における転帰不良の要因である可能性がある.
・外傷後の凝固線溶系障害や抗血栓薬内服はtalk and deteriorateを惹起する可能性がある.
・高齢者頭部外傷は転帰不良であり,高齢者特有の身体能力の低下や解剖学的特徴,生理学的特徴に外傷リスクや悪化リスクがあると考えられている.
・Talk and deteriorateは高齢者頭部外傷における転帰不良の要因である可能性がある.
・外傷後の凝固線溶系障害や抗血栓薬内服はtalk and deteriorateを惹起する可能性がある.
参考文献
1)内閣府:令和2年版高齢社会白書. https://www8.cao.go.jp/kourei/whitepaper/w-2020/zenbun/02pdf_index.html(2021年6月6日アクセス)
2)亀山元信,他:宮城頭部外傷研究会多施設共同登録調査—年齢と受傷原因・病態・転帰.神経外傷 31:49-56, 2008
3)加藤侑哉,他:重症頭部外傷における年齢構成の推移—頭部外傷データバンク【プロジェクト1998,2004,2009,2015】の変遷.神経外傷 42:160-167, 2019
4)Howard MA 3rd, et al:Acute subdural hematomas:an age-dependent clinical entity. J Neurosurg 71:858-863, 1989
5)Jane JA, et al:Age and outcome of head injury. Narayan RK, et al(eds):Neurotrauma. McGraw-Hill, New York, 1996, pp. 793-804
6)横堀將司,他:高齢者重症頭部外傷に対する積極的治療と患者転帰の変遷—頭部外傷データバンク【プロジェクト1998,2004,2009】における検討.神経外傷 36:76-85, 2013
7)Kannus P, et al:Increasing number and incidence of fall-induced severe head injuries in older adults:nationwide statistics in Finland in 1970-1995 and prediction for the future. Am J Epidemiol 149:143-150, 1999
8)Milos V, et al:Fall risk-increasing drugs and falls:a cross-sectional study among elderly patients in primary care. BMC Geriatr 14:40, 2014
9)Eisenberg HM, et al:Initial CT findings in 753 patients with severe head injury. A report from the NIH Traumatic Coma Data Bank. J Neurosurg 73:688-698, 1990
10)小野純一,他:高齢者重症頭部外傷例の問題点—神経症状,CT所見による分析.No Shinkei Geka 21:717-721, 1993
11)Hedman AM, et al:Human brain changes across the life span:a review of 56 longitudinal magnetic resonance imaging studies. Hum Brain Mapp 33:1987-2002, 2012
12)Chen JJ, et al:Age-associated reductions in cerebral blood flow are independent from regional atrophy. Neuroimage 55:468-478, 2011
13)Meyer JS, et al:Cerebral circulation in the elderly. Cerebrovasc Brain Metab Rev 5:122-146, 1993
14)Czosnyka M, et al:Age, intracranial pressure, autoregulation, and outcome after brain trauma. J Neurosurg 102:450-454, 2005
15)Peisker T, et al:Impact of aging on cerebral vasoregulation and parenchymal integrity. J Neurol Sci 299:112-115, 2010
16)Choi JY, et al:Aging and cerebrovascular disease. Neurol Clin 16:687-711, 1998
17)Bouma GJ, et al:Cerebral circulation and metabolism after severe traumatic brain injury:the elusive role of ischemia. J Neurosurg 75:685-693, 1991
18)Marion DW, et al:Acute regional cerebral blood flow changes caused by severe head injuries. J Neurosurg 74:407-414, 1991
19)刈部 博,他:高齢者頭部外傷後のsymptomatic hemispheric hyperperfusion. CI研究 31:255-262, 2010
20)Chieregato A, et al:Hyperemia beneath evacuated acute subdural hematoma is frequent and prolonged in patients with an unfavorable outcome:a xe-computed tomographic study. Neurosurgery 64:705-717;discussion 717-718, 2009
21)Deiner S, et al:Management of trauma in the geriatric patient. Curr Opin Anaesthesiol 17:165-170, 2004
22)Pudelek B:Geriatric trauma:special needs for a special population. AACN Clin Issues 13:61-72, 2002
23)Demetriades D, et al:Effect on outcome of early intensive management of geriatric trauma patients. Br J Surg 89:1319-1322, 2002
24)Grossman MD, et al:When is an elder old? Effect of preexisting conditions on mortality in geriatric trauma. J Trauma 52:242-246, 2002
25)Yilmaz S, et al:The impact of associated diseases on the etiology, course and mortality in geriatric trauma patients. Eur J Emerg Med 13:295-298, 2006
26)Lobato RD, et al:Head-injured patients who talk and deteriorate into coma. Analysis of 211 cases studied with computerized tomography. J Neurosurg 75:256-261, 1991
27)川又達朗,片山容一:Talk and deteriorate 86症例の検討—臨床像,治療,転帰について.神経外傷 25:205-209, 2002
28)刈部 博,他:高齢者頭部外傷におけるtalk and deteriorateのリアル.Neurosurg Emerg 25:187-194, 2020
29)Albeck MJ, et al:Age dependency of resistance to cerebrospinal fluid outflow. J Neurosurg 89:275-278, 1998
30)Ferrera PC, Bartfield JM:Outcomes of anticoagulated trauma patients. Am J Emerg Med 17:154-156, 1999
31)Gaetani P, et al:Traumatic brain injury in the elderly:considerations in a series of 103 patients older than 70. J Neurosurg Sci 56:231-237, 2012
32)Karni A, et al:Traumatic head injury in the anticoagulated elderly patient:a lethal combination. Am Surg 67:1098-1100, 2001
33)Mina AA, et al:Intracranial complications of preinjury anticoagulation in trauma patients with head injury. J Trauma 53:668-672, 2002
34)Lavoie A, et al:Preinjury warfarin use among elderly patients with closed head injuries in a trauma center. J Trauma 56:802-807, 2004
35)Ohm C, et al:Effects of antiplatelet agents on outcomes for elderly patients with traumatic intracranial hemorrhage. J Trauma 58:518-522, 2005
36)Cohen DB, et al:Traumatic brain injury in anticoagulated patients. J Trauma 60:553-557, 2006
37)Franko J, et al:Advanced age and preinjury warfarin anticoagulation increase the risk of mortality after head trauma. J Trauma 61:107-110, 2006
38)Pieracci FM, et al:Degree of anticoagulation, but not warfarin use itself, predicts adverse outcomes after traumatic brain injury in elderly trauma patients. J Trauma 63:525-530, 2007
39)Ivascu FA, et al:Predictors of mortality in trauma patients with intracranial hemorrhage on preinjury aspirin or clopidogrel. J Trauma 65:785-788, 2008
40)Wong DK, et al:The effects of clopidogrel on elderly traumatic brain injured patients. J Trauma 65:1303-1308, 2008
41)Inamasu J, et al:Influence of age and anti-platelet/anti-coagulant use on the outcome of elderly patients with fall-related traumatic intracranial hemorrhage. Neurol Med Chir(Tokyo)50:1051-1055, 2010
42)Davis DP, et al:Head-injured patients who “talk and die”:the San Diego perspective. J Trauma 62:277-281, 2007
43)Itshayek E, et al:Delayed posttraumatic acute subdural hematoma in elderly patients on anticoagulation. Neurosurgery 58:E851-E856, 2006
44)刈部 博:日本脳神経外科学会,日本脳神経外傷学会(監),頭部外傷治療・管理のガイドライン作成委員会(編):頭部外傷治療・管理のガイドライン 第4版.医学書院,東京,2019, pp. 173-180
45)Baugh CW, et al:Anticoagulant reversal strategies in the emergency department setting:recommendations of a multidisciplinary expert panel. Ann Emerg Med 76:470-485, 2020
46)Beynon C, et al:Clinical review:traumatic brain injury in patients receiving antiplatelet medication. Crit Care 16:228, 2012.
47)Powner DJ, et al:Counteracting the effects of anticoagulants and antiplatelet agents during neurosurgical emergencies. Neurosurgery 57:823-831, 2005
48)Desborough MJ, et al:Desmopressin for treatment of platelet dysfunction and reversal of antiplatelet agents:a systematic review and meta-analysis of randomized controlled trials. J Thromb Haemost 15:263-272, 2017
49)Grottke O, et al:Efficacy of prothrombin complex concentrates for the emergency reversal of dabigatran-induced anticoagulation. Crit Care 20:115, 2016
掲載誌情報