Neurological Surgery 脳神経外科50巻1号

2022年01月発行

特集 Precision Medicine—個別化医療を目指した遺伝子診断と新治療の知見 Ⅲ脳血管障害

脳動脈瘤—遺伝子解析と治療薬開発の現状

著者： 青木友浩¹ 栢原智道¹² 小野功朗¹³ 岡田明大¹³

所属機関： ¹国立循環器病研究センター研究所分子薬理部 ²埼玉医科大学国際医療センター脳卒中外科 ³京都大学大学院医学研究科脳神経外科学

ページ範囲：P.179 - P.195

Point
・一塩基多型の解析では，複数の多型で脳動脈瘤との関連が示されている．そのため，脳動脈瘤は多因子疾患であると考えられる．
・脳動脈瘤多発家系や遺伝病において，細胞外基質や内皮細胞に関連する遺伝子などが原因遺伝子として同定されている．
・スタチン製剤やアスピリンの服用による脳動脈瘤破裂に起因するくも膜下出血発症抑制効果が臨床研究により示されている．

参考文献

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