Neurological Surgery 脳神経外科52巻6号

2024年11月発行

総説

脳卒中後てんかんと脳血管性認知症

著者： 田中智貴¹ 猪原匡史¹

所属機関： ¹国立循環器病研究センター脳神経内科

ページ範囲：P.1279 - P.1290

文献概要

Ⅰ はじめに
　近年，脳神経外科治療，血栓溶解療法や脳血管内治療の飛躍的な発展により，脳卒中死亡率は劇的に改善してきている．一方，超高齢化社会，食生活の欧米化に伴い，脳卒中の罹患者は依然として多く，脳卒中生存者の後遺症，合併症の負担の軽減は重要な課題となっている^1）．脳卒中後てんかんは，後天的に発症するてんかんのなかで脳神経外科医が最も高頻度に遭遇するてんかんであり，脳卒中生存者の重要な合併症の1つである．近年の報告では，高齢者のてんかんの原因の約半数を占めるという報告もある^2）．また，血管性認知症（vascular dementia：VaD）も近年のアルツハイマー病（Alzheimer disease：AD）のアミロイドβ抗体療法と相まって，その病態の理解は脳神経領域では必須のものとなっている．
　本稿では，脳卒中後てんかん，VaDそれぞれにおける必須の知識について解説する．

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