検査と技術42巻7号

2014年07月発行

Laboratory Practice 〈病理〉

乳腺腫瘍の分子マーカーと遺伝子検索

著者： 増田しのぶ¹

所属機関： ¹日本大学医学部病態病理学系腫瘍病理学分野

ページ範囲：P.712 - P.716

はじめに

　乳腺腫瘍の発癌および治療の標的分子探索に関する研究については個別的要素が強い．本稿においては，日常診療に必要な知識として，乳腺腫瘍の分子マーカーと遺伝子検索の実際的な内容を中心に解説する．

参考文献

1）Goldhirsch A, Winer EP, Coates AS, et al : Personalizing the treatment of women with early breast cancer : highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann Oncol　24：2206-2223，2013

2）Wolff AC, Hammond ME, Hicks DG, et al : Recommendations for human epidermal growth factor receptor 2 testing in breast cancer : American Society of Clinical Oncology/college of American Pathologists clinical practice guideline update. Arch Pathol Lab Med　138：241-256，2014

3）Wolff AC, Hammond ME, Schwartz JN, et al : American Society of Clinical Oncology/College of American Pathologists. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. Arch Pathol Lab Med　131：18-43，2007

4）Hammond ME, Hayes DF, Dowsett M, et al : American Society of Clinical Oncology; College of American Pathologists. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version). Arch Pathol Lab Med　134：e48-e72，2010