icon fsr

文献詳細

雑誌文献

検査と技術51巻9号

2023年09月発行

文献概要

増大号 匠から学ぶ 血栓止血検査ガイド 5章 疾患まとめ

深部静脈血栓症(DVT)/肺血栓塞栓症(PE)

著者: 荻原義人1 土肥薫1 伊藤正明1

所属機関: 1三重大学医学部附属病院循環器内科

ページ範囲:P.1111 - P.1115

文献購入ページに移動
疾患概念

 肺血栓塞栓症(pulmonary thromboembolism:PTEまたはPE,本稿ではPEを用いる.なお,本稿でのPEは急性PEを指す)と深部静脈血栓症(deep vein thrombosis:DVT)は一連の病態と考えられており,まとめて静脈血栓塞栓症(venous thromboembolism:VTE)と呼ばれる.

 四肢の筋膜より深層を走行する深部静脈に発生した血栓症をDVTと呼び,それより中枢側に位置する腸骨静脈,下大静脈,鎖骨下静脈,腕頭静脈,上大静脈,さらに内頸静脈に発生した血栓症もDVTに含まれる.静脈血栓が遊離し,塞栓子として肺動脈を閉塞した結果,PEを発症する.PEの塞栓源の約90%は下肢あるいは骨盤内の静脈由来とされる1)

参考文献

1)日本循環器学会,他.肺血栓塞栓症および深部静脈血栓症の診断,治療,予防に関するガイドライン(2017年改訂版).2017. https://js-phlebology.jp/wp/wp-content/uploads/2020/08/JCS2017.pdf(2023年6月21日アクセス)
2)Heit JA, et al. The epidemiology of venous thromboembolism. J Thromb Thrombolysis. 2016; 41: 3-14.
3)Lutsey PL, Zakai NA. Epidemiology and prevention of venous thromboembolism. Nat Rev Cardiol. 2023; 20: 248-262.
4)Nakamura M, et al. Current management of venous thromboembolism in Japan: Current epidemiology and advances in anticoagulant therapy. J Cardiol. 2015; 66: 451-459.
5)Kuroiwa M, et al. Changes in the incidence, case fatality rate, and characteristics of symptomatic perioperative pulmonary thromboembolism in Japan: Results of the 2002-2011 Japanese Society of Anesthesiologists Perioperative Pulmonary Thromboembolism (JSA-PTE) Study. J Anesth. 2015; 29: 433-441.
6)Ota S, et al. Incidence, Characteristics and Management of Venous Thromboembolism in Japan During 2011. Circ J. 2018; 82: 555-560.
7)Nakamura M, et al. Current venous thromboembolism management and outcomes in Japan. Circ J. 2014; 78: 708-717.
8)Yamashita Y, et al. Anticoagulation Therapy for Venous Thromboembolism in the Real World - From the COMMAND VTE Registry. Circ J. 2018; 82: 1262-1270.
9)Carson JL, et al. The clinical course of pulmonary embolism. N Engl J Med. 1992; 326: 1240-1245.
10)Yamashita Y, et al. Validation of simplified PESI score for identification of low-risk patients with pulmonary embolism: From the COMMAND VTE Registry. Eur Heart J Acute Cardiovasc Care. 2020; 9: 262-270.
11)Stark, K et al. Interplay between inflammation and thrombosis in cardiovascular pathology. Nat Rev Cardiol. 2021; 18: 666-682.
12)Stein PD, et al. D-dimer for the exclusion of acute venous thrombosis and pulmonary embolism: a systematic review. Ann Intern Med. 2004; 140: 589-602.
13)Konstantinides SV, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J. 2020; 41: 543-603.
14)Johnson ED, et al. The D-dimer assay. Am J Hematol. 2019; 94: 833-839.
15)Palareti G, et al. D-dimer testing to determine the duration of anticoagulation therapy. N Engl J Med. 2006; 355: 1780-1789.
16)Douketis J, et al. Patient-level meta-analysis: effect of measurement timing, threshold, and patient age on ability of D-dimer testing to assess recurrence risk after unprovoked venous thromboembolism. Ann Intern Med. 2010; 153: 523-531.
17)Cosmi B, et al. Sex, age and normal post-anticoagulation D-dimer as risk factors for recurrence after idiopathic venous thromboembolism in the Prolong study extension. J Thromb Haemost. 2010; 8: 1933-1942.
18)Wada H, et al. Elevated levels of soluble fibrin or D-dimer indicate high risk of thrombosis. J Thromb Haemost. 2006; 4: 1253-1258.
19)Cosmi B, et al. Usefulness of repeated D-dimer testing after stopping anticoagulation for a first episode of unprovoked venous thromboembolism: the PROLONG Ⅱ prospective study. Blood 2010; 115: 481-488.

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1375

印刷版ISSN:0301-2611

雑誌購入ページに移動
icon up
あなたは医療従事者ですか?