公衆衛生79巻12号

2015年12月発行

連載 ［講座］子どもを取り巻く環境と健康・10

乳幼児のアレルギーと胎児期・小児期の可塑剤・難燃剤曝露

著者： 荒木敦子¹ アイツバマイゆふ¹ 岸玲子¹

所属機関： ¹北海道大学環境健康科学研究教育センター

ページ範囲：P.876 - P.881

　連載第9回で宮下らは，世界各国でのアレルギー疾患の有病率の増加および発症の低年齢化の原因の1つとして，ダイオキシン類や有機フッ素系化学物質など残留性有機汚染物質(POPs)曝露による影響について述べた．本稿では，乳幼児のアレルギーの一因として，可塑剤・難燃剤として多くの日用品に汎用されているフタル酸エステル類・リン酸トリエステル類曝露による影響について，最近の科学的知見を紹介する．

参考文献

1)Jaakkola JJ, et al:Plastic wall materials in the home and respiratory health in young children. Am J Public Health 90(5):797-799, 2000

2)Just AC et al:Prenatal Exposure to Butylbenzyl Phthalate and Early Eczema in an Urban Cohort. Environ Health Perspect 120(10):1475-1480, 2012

3)Whyatt RM, et al:Asthma in Inner-City Children at 5-11 Years of Age and Prenatal Exposure to Phthalates:The Columbia Center for Children's Environmental Health Cohort. Environ Health Perspect 122(10):1141-1146, 2014

4)Gascon M, et al:Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy. J Allergy Clin Immunol 135(2):370-378, 2014

5)Wang IJ, et al:Early life phthalate exposure and atopic disorders in children:a prospective birth cohort study. Environ Int 62:48-54, 2014

6)Ku HY, et al:Prenatal and postnatal exposure to phthalate esters and asthma:a 9-year follow-up study of a taiwanese birth cohort. PLoS One 10(4):e0123309, 2015

7)Callesen M, et al:Phthalate metabolites in urine and asthma, allergic rhinoconjunctivitis and atopic dermatitis in preschool children. Int J Hyg Environ Health 217(6):645-652, 2014

8)Just AC, et al:Children's urinary phthalate metabolites and fractional exhaled nitric oxide in an urban cohort. Am J Respir Crit Care Med 186(9):830-837, 2012

9)Hoppin JA, et al:Phthalate Exposure and Allergy in the U.S. Population:Results from NHANES 2005-2006. Environ Health Perspect 121(10):1129-1134, 2013

10)Bertelsen RJ, et al:Urinary biomarkers for phthalates associated with asthma in Norwegian children. Environ Health Perspect 121(2):251-256, 2013

11)Hsu NY, et al:Predicted risk of childhood allergy, asthma, and reported symptoms using measured phthalate exposure in dust and urine. Indoor Air 22(3):186-199, 2012

12)Kolarik B, et al:The association between phthalates in dust and allergic diseases among Bulgarian children. Environ Health Perspect 116(1):98-103, 2008

13)Callesen M, et al:Associations between selected allergens, phthalates, nicotine, polycyclic aromatic hydrocarbons, and bedroom ventilation and clinically confirmed asthma, rhinoconjunctivitis, and atopic dermatitis in preschool children. Indoor Air 24(2):136-147, 2013

14)Bornehag CG, et al:The association between asthma and allergic symptoms in children and phthalates in house dust:A nested case-control study. Environ Health Perspect 112(14):1393-1397, 2004

15)Ait Bamai Y, et al:Exposure to house dust phthalates in relation to asthma and allergies in both children and adults. Sci Total Environ 485-486:153-163, 2014

16)Ait Bamai Y, et al:Associations of phthalate concentrations in floor dust and multi-surface dust with the interior materials in Japanese dwellings. Sci Total Environ 468-469:147-157, 2014

17)Ait Bamai Y, et al:Comparisons of urinary phthalate metabolites and daily phthalate intakes among Japanese families. Int J Hyg Environ Health 218(5):461-470, 2015

18)Chen SQ, et al:Perinatal exposure to di-(2-ethylhexyl)phthalate leads to restricted growth and delayed lung maturation in newborn rats. J Perinat Med 38(5):515-521, 2010

19)Tanaka M, et al:, In vivo immunoamplifying effects of di-(2-ethylhexyl)phthalate on cytokine response. Immunopharmacol Immunotoxicol 35(1):147-150, 2013

20)Hansen JS, et al:Adjuvant effects of inhaled mono-2-ethylhexyl phthalate in BALB/cJ mice. Toxicology 232(1-2):79-88, 2007

21)Araki A, et al:Phosphorus flame retardants in indoor dust and their relation to asthma and allergies of inhabitants. Indoor Air 24(1):3-15, 2014