公衆衛生79巻6号

2015年06月発行

連載 ［講座］子どもを取り巻く環境と健康・4 環境化学物質の曝露(3)

有機フッ素系化学物質(PFCs)の曝露実態

著者： 原田浩二¹ 小泉昭夫¹

所属機関： ¹京都大学大学院医学研究科環境衛生学分野

ページ範囲：P.413 - P.418

　新たなPOPsとして2000年以降，急速に汚染物質として認識され，なお現在も汚染実態が未解明な点がある有機フッ素系化学物質について解説する．有機フッ素系化学物質がどのような用途，場所で使用，検出されるのかをこれまでの調査例から知ってもらいたい．特に日本ほか，東アジアでは欧米とは異なる有機フッ素系化学物質が観察されることを紹介する．有機フッ素系化学物質の曝露は主に食品を介していると考えられるが，局所的には，有機フッ素化学物質を使用する事業所の周辺では水や大気を介した曝露が大きくなる点について留意したい．

参考文献

1)Saito N, et al:Perfluorooctanoate and perfluorooctane sulfonate concentrations in surface water in Japan. J Occup Health 46(1):49-59, 2004

2)Niisoe T, et al:Long-Term Simulation of Human Exposure to Atmospheric Perfluorooctanoic Acid(PFOA)and Perfluorooctanoate(PFO)in the Osaka Urban Area, Japan. Environ Sci Technol 44(20):7852-7857, 2010

3)Liu W, et al:Analysis of perfluoroalkyl carboxylates in vacuum cleaner dust samples in Japan. Chemosphere 85(11):1734-1741, 2011

4)Fujii Y, et al:Occurrence of perfluorinated carboxylic acids(PFCAs)in personal care products and compounding agents. Chemosphere 93(3):538-544, 2013

5)Koizumi A, et al:Past, present, and future of environmental specimen banks. Environ Health Prev Med 14(6):307-318, 2009

6)Harada K, et al:Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan. Chemosphere 66(2):293-301, 2007

7)Harada KH, et al:Levels of perfluorooctane sulfonate and perfluorooctanoic acid in female serum samples from Japan in 2008, Korea in 1994-2008 and Vietnam in 2007-2008. Chemosphere 79(3):314-319, 2010

8)Harada KH, et al:Odd-numbered perfluorocarboxylates predominate over perfluorooctanoic acid in serum samples from Japan, Korea and Vietnam. Environ Int 37(7):1183-1189, 2011

9)Jin Y, et al:Historical trends in human serum levels of perfluorooctanoate and perfluorooctane sulfonate in Shenyang, China. Tohoku J Exp Med 212(1):63-70, 2007

10)Okada E, et al:Temporal trends of perfluoroalkyl acids in plasma samples of pregnant women in Hokkaido, Japan, 2003-2011. Environ Int 60:89-96, 2013

11)Fujii Y, et al:Analysis of perfluoroalkyl carboxylic acids in composite dietary samples by gas chromatography/mass spectrometry with electron capture negative ionization. Environ Sci Technol 46(20):11235-11242, 2012

12)Inoue K, et al:Perfluorooctane sulfonate(PFOS)and related perfluorinated compounds in human maternal and cord blood samples:assessment of PFOS exposure in a susceptible population during pregnancy. Environ Health Perspect 112(11):1204-1207, 2004

13)Fujii Y, et al:Levels and profiles of long-chain perfluorinated carboxylic acids in human breast milk and infant formulas in East Asia. Chemosphere 86(3):315-321, 2012

14)Bach CC, et al:Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth:A systematic review. Crit Rev Toxicol 45(1)：53-67, 2015

15)Kärrman A, et al:Relationship between dietary exposure and serum perfluorochemical(PFC)levels—a case study. Environ Int 35(4):712-717, 2009

16)Harada K, et al:Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion. Environ Res 99(2):253-261, 2005

17)Fujii Y, et al:Toxicokinetics of perfluoroalkyl carboxylates with different carbon chain lengths in mice and humans. J Occup Health 57(1):1-12, 2015