公衆衛生80巻10号

2016年10月発行

連載 ［講座］子どもを取り巻く環境と健康・20

環境化学物質曝露による先天異常への影響—(1) 尿道下裂，停留精巣

著者： 三井貴彦¹²

所属機関： ¹山梨大学大学院 医学工学総合研究部 泌尿器科学 ²北海道大学 環境健康科学研究教育センター

ページ範囲：P.775 - P.779

　妊娠期および胎児期における内分泌かく乱物質(EDCs)への曝露が，児の性腺機能，性分化や第二次性徴の発来に影響を与える懸念が世界的に高まっており，本稿で紹介するように，EDCs曝露が尿道下裂や停留精巣などの先天異常に与える影響が明らかになりつつある．しかし，その結果には，いまだ確立されたものはなく，今後も新たなエビデンスの蓄積が必要である．特に，本邦からのエビデンスの高いデータの発信が望まれる．

参考文献

1)Bergman Å, et al(eds):State of the Science of Endocrine Disrupting Chemicals-2012. United Nations Environment Programme and the World Health Organization, 2013

2)Sharpe RM, Irvine DS:How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health? BMJ 328(7437)：447-451, 2004

3)Moriya K, et al:Long-term cosmetic and sexual outcome of hypospadias surgery:norm related study in adolescence. J Urol 176(4 Pt 2):1889-1892;discussion 1892-1893, 2006

4)Moriya K, et al:Long-term patient reported outcome of urinary symptoms after hypospadias surgery:norm related study in adolescents. J Urol 178(4 Pt 2):1659-1662;discussion 1662, 2007

5)Moriya K, et al:Long-term outcome of pituitary-gonadal axis and gonadal growth in patients with hypospadias at puberty. J Urol 184(4 Suppl)：1610-1614, 2010

6)Giordano F, et al:Maternal exposures to endocrine disrupting chemicals and hypospadias in offspring. Birth Defects Res A Clin Mol Teratol 88(4)：241-250, 2010

7)Rocheleau CM, et al:Pesticides and hypospadias:a meta-analysis. J Pediatr Urol 5(1)：17-24, 2009

8)Carbone P, et al:Cryptorchidism and hypospadias in the Sicilian district of Ragusa and the use of pesticides. Reprod Toxicol 22(1)：8-12, 2006

9)Christensen JS, et al:Association between organic dietary choice during pregnancy and hypospadias in offspring:a study of mothers of 306 boys operated on for hypospadias. J Urol 189(3)：1077-1082, 2013

10)Ormond G, et al:Endocrine disruptors in the workplace, hair spray, folate supplementation, and risk of hypospadias:case-control study. Environ Health Perspect 117(2)：303-307, 2009

11)Rignell-Hydbom A, et al:A nested case-control study of intrauterine exposure to persistent organochlorine pollutants and the risk of hypospadias. PLoS One 7(9):e44767, 2012

12)North K, Golding J:A maternal vegetarian diet in pregnancy is associated with hypospadias. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. BJU Int 85(1)107-113, 2000

13)Damgaard IN, et al:Persistent pesticides in human breast milk and cryptorchidism. Environ Health Perspect 114(7)：1133-1138, 2006

14)Jørgensen KT, et al:Risk of cryptorchidism among sons of horticultural workers and farmers in Denmark. Scand J Work Environ Health 40(3)：323-330, 2014

15)Carran M, Shaw IC:New Zealand Malayan war veterans' exposure to dibutylphthalate is associated with an increased incidence of cryptorchidism, hypospadias and breast cancer in their children. N Z Med J 125(1358)：52-63, 2012

16)Skakkebaek NE, et al:Testicular dysgenesis syndrome:an increasingly common developmental disorder with environmental aspects. Hum Reprod 16(5)：972-978, 2001

17)Araki A, et al:Association between maternal exposure to di(2-ethylhexyl)phthalate and reproductive hormone levels in fetal blood:the Hokkaido study on environment and children's health. PLoS One 9(10):e109039, 2014

18)Mitsui T, et al:Effects of prenatal Leydig cell function on the ratio of the second to fourth digit lengths in school-aged children. PLoS One 10(3):e0120636, 2015