公衆衛生84巻4号

2020年04月発行

特集 ゲノム革命—予防・医療のイノベーション

ゲノム革命の足跡と予防・医療の近未来

著者： 宮野悟¹

所属機関： ¹東京大学医科学研究所ヒトゲノム解析センター

ページ範囲：P.214 - P.219

【ポイント】
◆次世代シーケンサーの発展によって，個々人のゲノム情報に基づく医療が現実となった．
◆がんゲノム研究によって，がんの複雑さが一層，明らかになりつつある．
◆人工知能(AI)の支援によって，がんの臨床シーケンス解析にスピードが出るようになった．しかし，現時点では専門医から置き換わるものとはなっていない．

参考文献

1)National Human Genome Research Institute:The Human Genome Project.　https://www.genome.gov/human-genome-project

2)National Human Genome Research Institute:International HapMap Project.　https://www.genome.gov/10001688/international-hapmap-project

3)National Cancer Institute:The Cancer Genome Atlas Program.　https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga

4)the WHITE HOUSE:THE PRECISION MEDICINE INITIATIVE.　https://obamawhitehouse.archives.gov/precision-medicine

.　https://www.cancer.gov/research/key-initiatives/moonshot-cancer-initiative

6)International Cancer Genome Consortium.　https://icgc.org/

7)IGSR:The International Genome Sample Resource.　https://www.internationalgenome.org/

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16)Nakamura S, et al:Circulating tumor DNA dynamically predicts response and/or relapse in patients with hematological malignancies. Int J Hematol 108:402-410, 2018