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雑誌文献

臨床眼科63巻1号

2009年01月発行

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連載 今月の話題

一酸化窒素と網膜疾患

著者: 米今敬一1

所属機関: 1名古屋大学大学院医学系研究科眼科学・感覚器障害制御学教室

ページ範囲:P.9 - P.14

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 一酸化窒素(NO)には実に多様な生理活性作用があり,その不足や過剰産生は全身のさまざまな疾患に関与している。本稿においては,代表的な網膜硝子体疾患である糖尿病網膜症,加齢黄斑変性,未熟児網膜症および網膜色素変性症におけるNOの果たしている役割に焦点を絞り,臨床医がその病態生理を考察する際の手助けとなるように最新の知見を疾患別に紹介する。

参考文献

1)藤崎美奈子・一守康史・中澤博江:NOの代謝と測定法.大柳善彦(編):NOラジカルの医学.14-28,羊土社,東京,1996
2)平田結喜緒:NOSの構造と機能.大柳善彦(編):NOラジカルの医学.29-41,羊土社,東京,1996
3)Toda N, Nakanishi-Toda M:Nitric oxide:ocular blood flow, glaucoma, and diabetic retinopathy. Prog Retin Eye Res 26:205-238, 2007
4)Doganay S, Evereklioglu C, Er H et al:Comparison of serum NO, TNF-alpha, IL-1beta, sIL-2R, IL-6 and IL-8 levels with grades of retinopathy in patients with diabetes mellitus. Eye 16:163-170, 2002
5)Ozden S, Tatlipinar S, Biçer N et al:Basal serum nitric oxide levels in patients with type 2 diabetes mellitus and different stages of retinopathy. Can J Ophthalmol 38:393-396, 2003
6)Cicik E, Tekin H, Akar S et al:Interleukin-8, nitric oxide and glutathione status in proliferative vitreoretinopathy and proliferative diabetic retinopathy. Ophthalmic Res 35:251-255, 2003
7)Hernández C, Lecube A, Segura RM et al:Nitric oxide and vascular endothelial growth factor concentrations are increased but not related in vitreous fluid of patients with proliferative diabetic retinopathy. Diabet Med 19:655-660, 2002
8)Abu El-Asrar AM, Van Aelst I, Al-Mansouri S et al:Expression of the inducible isoform of nitric oxide synthase in the retinas of human subjects with diabetes mellitus. Am J Ophthalmol 132:551-556, 2001
9)Schaefer S, Kajimura M, Tsuyama S et al:Aberrant utilization of nitric oxide and regulation of soluble guanylate cyclase in rat diabetic retinopathy. Antioxid Redox Signal 5:457-465, 2003
10)Sennlaub F, Courtois Y, Goureau O:Inducible nitric oxide synthase mediates the change from retinal to vitreal neovascularization in ischemic retinopathy. J Clin Invest 107:717-725, 2001
11)Sennlaub F, Courtois Y, Goureau O:Inducible nitric oxide synthase mediates retinal apoptosis in ischemic proliferative retinopathy. J Neurosci 22:3987-3993, 2002
12)Du XL, Edelstein D, Dimmeler S et al:Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. J Clin Invest 108:1341-1348, 2001
13)El-Remessy AB, Abou-Mohamed G, Caldwell RW et al:High glucose-induced tyrosine nitration in endothelial cells:role of eNOS uncoupling and aldose reductase activation. Invest Ophthalmol Vis Sci 44:3135-3143, 2003
14)Evereklioglu C, Er H, Doganay S et al:Nitric oxide and lipid peroxidation are increased and associated with decreased antioxidant enzyme activities in patients with age-related macular degeneration. Doc Ophthalmol 106:129-136, 2003
15)Totan Y, Cekiç O, Borazan M et al:Plasma malondialdehyde and nitric oxide levels in age related macular degeneration. Br J Ophthalmol 85:1426-1428, 2008
16)Tsai DC, Charng MJ, Lee FL et al:Different plasma levels of vascular endothelial growth factor and nitric oxide between patients with choroidal and retinal neovascularization. Ophthalmologica 220:246-251, 2006
17)Ando A, Yang A, Nambu H et al:Blockade of nitric-oxide synthase reduces choroidal neovascularization. Mol Pharmacol 62:539-544, 2002
18)Ando A, Yang A, Mori K et al:Nitric oxide is proangiogenic in the retina and choroid. J Cell Physiol 191:116-124, 2002
19)Hattenbach LO, Falk B, Nürnberger F et al:Detection of inducible nitric oxide synthase and vascular endothelial growth factor in choroidal neovascular membranes. Ophthalmologica 216:209-214, 2002
20)She H, Nakazawa T, Matsubara A et al:Reduced photoreceptor damage after photodynamic therapy through blockade of nitric oxide synthase in a model of choroidal neovascularization. Invest Ophthalmol Vis Sci 48:2268-2277, 2007
21)Beauchamp MH, Sennlaub F, Speranza G et al:Redox-dependent effects of nitric oxide on microvascular integrity in oxygen-induced retinopathy. Free Radic Biol Med 37:1885-1894, 2004
22)Alon T, Hemo I, Itin A et al:Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1:1024-1028, 1995
23)Brooks SE, Gu X, Samuel S et al:Reduced severity of oxygen-induced retinopathy in eNOS-deficient mice. Invest Ophthalmol Vis Sci 42:222-228, 2001
24)Gu X, El-Remessy AB, Brooks SE et al:Hyperoxia induces retinal vascular endothelial cell apoptosis through formation of peroxynitrite. Am J Physiol Cell Physiol 285:C546-C554, 2003
25)Kermorvant-Duchemin E, Sennlaub F, Sirinyan M et al:Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration. Nat Med 11:1339-1345, 2005
26)Smith LE, Connor KM:A radically twisted lipid regulates vascular death. Nat Med 11:1275-1276, 2005
27)Káldi I, Dittmar M, Pierce P et al:L-NAME protects against acute light damage in albino rats, but not against retinal degeneration in P23H and S334ter transgenic rats. Exp Eye Res 76:453-461, 2003
28)Komeima K, Usui S, Shen J et al:Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa. Free Radic Biol Med 45:905-912, 2008
29)Hughes EH, Schlichtenbrede FC, Murphy CC et al:Generation of activated sialoadhesin-positive microglia during retinal degeneration. Invest Ophthalmol Vis Sci 44:2229-2234, 2003

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1308

印刷版ISSN:0370-5579

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