臨床眼科65巻8号

2011年08月発行

連載 今月の話題

緑内障の網膜電図異常

著者： 町田繁樹¹ 金子宗義¹

所属機関： ¹岩手医科大学眼科学教室

ページ範囲：P.1205 - P.1211

　網膜電図（ERG）には網膜神経節細胞（RGC）に由来する応答が含まれている。これらを記録することで，RGC機能を他覚的に評価できる。これらのRGCの応答は視野検査で得られた網膜感度，網膜神経線維層あるいは視神経乳頭の形態変化と相関する。このことから，ERGに含まれたRGCの応答は緑内障の視機能検査の1つとなる可能性がある。

参考文献

1）Viswanathan S, Frishman LJ, Robson JG et al：The photopic negative response of the macaque electroretinogram：reduction by experimental glaucoma. Invest Ophthalmol Vis Sci　40：1124-1136, 1999

2）Viswanathan S, Frishman LJ, Robson JG et al：The photopic negative response of the flash electroretinogram in primary open angle glaucoma. Invest Ophthalmol Vis Sci　42：514-522, 2001

3）Gotoh Y, Machida S, Tazawa Y：Selective loss of the photopic negative response in patients with optic nerve atrophy. Arch Ophthalmol　122：341-346, 2004

4）Machida S, Gotoh Y, Tanaka M et al：Predominant loss of the photopic negative response in central retinal artery occlusion. Am J Ophthalmol　37：938-940, 2004

5）Maffei L, Fiorentini A：Electroretinographic responses to alternating gratings before and after section of the optic nerve. Science　211：953-955, 1981

6）Rangaswamy NV, Shirato S, Kaneko M et al：Effects of spectral characteristics of ganzfeld stimuli on the photopic negative response（PhNR）of the ERG. Invest Ophthalmol Vis Sci　48：4818-4828, 2007

7）Miyake Y, Yanagida K, Yagasaki K et al：Subjective scotometry and recording of local electroretinogram and visual evoked response. System with television monitor of the fundus. Jpn J Ophthalmol　25：439-448, 1981

8）Machida S, Gotoh Y, Toba Y et al：Correlation between photopic negative response and retinal nerve fiber layer thickness and optic disc topography in glaucomatous eyes. Invest Ophthalmol Vis Sci　49：2201-2207, 2008

9）Machida S, Toba Y, Ohtaki A et al：Photopic negative response of focal electroretinogram in glaucomatous eyes. Invest Ophthalmol Vis Sci　49：5636-5644, 2008

10）Machida S, Tamada K, Oikawa T et al：Sensitivity and specificity of photopic negative response of focal electroretinograms in detecting glaucomatous eyes. Br J Ophthalmol　94：202-208, 2010

11）Machida S, Tamada K, Oikawa T et al：Comparison of photopic negative response between full-field and focal electroretinograms in detecting glaucomatous eyes. J Ophthalmol, 564131, 2011［Epub］

12）Tamada K, Machida S, Oikawa T et al：Correlation between photopic negative response of focal electroretinograms and local loss of retinal neurons in glaucoma. Curr Eye Res　35：155-164, 2010

13）Sano M, Tazawa Y, Nabeshima T et al：A new wavelet in the multifocal electroretinogram, probably originating from ganglion cells. Invest Ophthalmol Vis Sci　43：1666-1672, 2002

14）Nitta J, Tazawa Y, Murai K et al：Relationship between the s-wave of the multifocal electroretinogram and the retinal nerve fiber layer thickness in glaucoma eyes. Jpn J Ophthalmol　49：481-490, 2005

15）Hood DC, Greenstein VC, Holopigian K et al：An attempt to detect glaucomatous damage to the inner retina with the multifocal ERG. Invest Ophthalmol Vis Sci　41：1570-1579, 2000

16）Viswanathan S, Frishman LJ, Robson JG：The uniform field and pattern ERG in macaques with experimental glaucoma：removal of spiking activity. Invest Ophthalmol Vis Sci　41：2797-2810, 2000

17）Garway-Heath DF, Holder GE, Fitzke FW et al：Relationship between electrophysiological, psychophysical, and anatomical measurements in glaucoma. Invest Ophthalmol Vis Sci　43：2213-2220, 2002