臨床眼科66巻11号

2012年10月発行

特集 オキュラーサーフェス診療アップデート 5．基礎研究と臨床とのつながり 感染症と免疫

眼表面の免疫特権

著者： 国重智之¹ 堀純子¹

所属機関： ¹日本医科大学眼科学教室

ページ範囲：P.346 - P.350

Point

1．免疫特権とは，過剰な炎症を自動制御して組織の恒常性を保護する特別な性質である。

2．眼表面には，角膜上皮側よりも内皮側に免疫特権がある。

3．角膜の免疫特権の仕組みとしては，① 解剖学的・細胞分子学的なバリア，② 前房関連免疫偏位（ACAID），③ 眼内免疫抑制性微小環境が挙げられる。

4．免疫特権は眼表面炎症の新しい治療法に応用できる。

参考文献

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