臨床眼科66巻7号

2012年07月発行

連載 今月の話題

抗加齢医学の最近の進歩と眼科疾患

著者： 綾木雅彦¹ 坪田一男²

所属機関： ¹国際医療福祉大学三田病院眼科 ²慶應義塾大学医学部眼科学教室

ページ範囲：P.953 - P.956

　抗加齢医学の科学的エビデンスが着実に蓄積されつつあり，従来は不可能とされてきた加齢疾患の予防や治療が現実的なものになりつつある。本稿では，最近めざましい研究成果が出てきているカロリス仮説とROS仮説について解説する。特にカロリス仮説は老化への全体的介入を可能にした画期的な学説であり，今後の発展が注目される。

参考文献

1）坪田一男：眼と加齢 活性酸素・炎症：エイジング仮説．日眼会誌　111：193-206，2007

2）川島素子・坪田一男：眼とアンチエイジング．総合臨牀　60：430-434，2011

3）Colman RJ, Anderson RM, Johnson SC et al：Caloric restriction delays disease onset and mortality in rhesus monkeys. Science　325：201-204, 2009

4）Bordone L, Guarente L：Calorie restriction, SIRT1 and metabolism：understanding longevity. Nat Rev Mol Cell Biol　6：298-305, 2005

5）Baur JA：Dietary restriction：standing up for sirtuins. Science　329：1012-1013, 2010

6）Guarente L：Sirtuins, aging, and medicine. N Engl J Med　364：2235-2244, 2011

7）Kaeberlein M, Kennedy BK：Ageing：a midlife longevity drug?　Nature　460：331-332, 2009

8）Fontana L, Partridge L, Longo VD：Extending healthy life span―from yeast to humans. Science　328：321-326, 2010

9）Spindler SR：Calorie restriction enhances the expression of key metabolic enzymes associated with protein renewal during aging. Ann N Y Acad Sci　928：296-304, 2001

10）Blagosklonny MV：Calorie restriction：decelerating mTOR-driven aging from cells to organisms（including humans）. Cell Cycle　9：683-688, 2010

11）Heilbronn LK, de Jonge L, Frisard MI et al：Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals：a randomized controlled trial. JAMA　295：1539-1548, 2006

12）Renaud S, de Lorgeril M：Alcohol, platelets, and the French paradox for coronary heart disases. Lancet　339：1523-1526, 1992

13）Baur JA, Pearson KJ, Price NL et al：Resveratrol improves health and survival of mice on a high-calorie diet. Nature　444：337-342, 2006

14）Anekonda TS：The benefits of calorie restriction and calorie restriction mimetics as related to the eye. Open Longev Sci　3：28-37, 2009

15）Taylor A, Lipman RD, Jahngen-Hodge J et al：Dietary calorie restriction in the Emory mouse：effects on lifespan, eye lens cataract prevalence and progression, levels of ascorbate, glutathione, glucose, and glycohemoglobin, tail collagen breaktime, DNA and RNA oxidation, skin integrity, fecundity, and cancer. Mech Ageing Dev　79：33-57, 1995

16）Kawashima M, Tsubota K：Effect of calorie restriction on change in lacrimal gland with age. Cornea　30（Suppl 1）：S29-S33, 2011

17）Kubota S, Ozawa Y, Kurihara T et al：Roles of AMP-activated protein kinase in diabetes-induced retinal inflammation. Invest Ophthalmol Vis Sci　52：9142-9148, 2011

18）Schriner SE, Linford NJ, Martin GM et al：Extension of murine life span by overexpression of catalase targeted to mitochondria. Science　308：1909-1911, 2005

19）Sun J, Folk D, Bradley TJ et al：Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. Genetics　161：661-672, 2002

20）Izumi-Nagai K, Nagai N, Ohgami K et al：Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin. Invest Ophthalmol Vis Sci　49：1679-1685, 2008

21）Sasaki M, Ozawa Y, Kurihara T et al：Neuroprotective effect of an antioxidant, lutein, during retinal inflammation. Invest Ophthalmol Vis Sci　50：1433-1439, 2009

22）Nakamura S, Shibuya M, Nakashima H et al：Involvement of oxidative stress on corneal epithelial alterations in a blink-suppressed dry eye. Invest Ophthalmol Vis Sci　48：1552-1558, 2007

23）Imamura Y, Noda S, Hashizume K et al：Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice：a model of age-related macular degeneration. Proc Natl Acad Sci USA　103：11282-11287, 2006

24）Higuchi A, Ito K, Dogru M et al：Corneal damage and lacrimal gland dysfunction in a smoking rat model. Free Radic Biol Med　51：2210-2216, 2011

25）Dogru M, Matsumoto Y, Yamamoto Y et al：Lactoferrin in Sjögren's syndrome. Ophthalmology　114：2366-2367, 2007

26）Higuchi A, Takahashi K, Hirashima M et al：Selenoprotein P controls oxidative stress in cornea. PLoS One　5：e9911, 2010