1)Ferrara N:Vascular endothelial growth factor and age-related macular degeneration:from basic science to therapy. Nat Med 16:1107-1111, 2010
2)Miller JW, Le Couter J, Strauss EC et al:Vascular endothelial growth factor a in intraocular vascular disease. Ophthalmology 120:106-114, 2013
3)Carmeliet P, Jain RK:Molecular mechanisms and clinical applications of angiogenesis. Nature 473:298-307, 2011
4)Ishida S, Shinoda K, Kawashima S et al:Coexpression of VEGF receptors VEGF-R2 and neuropilin-1 in proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 41:1649-1656, 2000
5)Gragoudas ES, Adamis AP, Cunningham ET Jr et al:Pegaptanib for neovascular age-related macular degeneration. N Engl J Med 351:2805-2816, 2004
6)Rosenfeld PJ, Brown DM, Heier JS et al:Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 355:1419-1431, 2006
7)Brown DM, Kaiser PK, Michels M et al:Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 355:1432-1444, 2006
8)Friberg TR, Tolentino M, Weber P et al:Pegaptanib sodium as maintenance therapy in neovascular age-related macular degeneration:the LEVEL study. Br J Ophthalmol 94:1611-1617, 2010
9)Varma R, Bressler NM, Suner I et al:Improved vision-related function after ranibizumab for macular edema after retinal vein occlusion:results from the BRAVO and CRUISE trials. Ophthalmology 119:2108-2118, 2012
10)Nguyen QD, Brown DM, Marcus DM et al:Ranibizumab for diabetic macular edema:results from 2 phase Ⅲ randomized trials:RISE and RIDE. Ophthalmology 119:789-801, 2012
11)Michels S, Rosenfeld PJ, Puliafito CA et al:Systemic bevacizumab(Avastin)therapy for neovascular age-related macular degeneration twelve-week results of an uncontrolled open-label clinical study, Ophthalmology 112:1035-1047, 2005
12)Martin DF, Maguire MG, Fine SL et al:Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration:two-year results. Ophthalmology 119:1388-1398, 2012
13)Gordon MS, Cunningham D:Managing patients treated with bevacizumab combination therapy. Oncology 69 Suppl 3:25-33, 2005
14)Ueta T, Yanagi Y, Tamaki Y et al:Cerebrovascular accidents in ranibizumab. Ophthalmology 116:362, 2009
15)Beyond cost considerations. Nat Med 18:835, 2012
16)Heier JS, Brown DM, Chong V et al:Intravitreal aflibercept(VEGF trap-eye)in wet age-related macular degeneration. Ophthalmology 119:2537-2548, 2012
17)Levine RJ, Maynard SE, Qian C et al:Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 350:672-683, 2004
18)Li Y, Zhang F, Nagai N et al:VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats. J Clin Invest 118:913-923, 2008
19)Murakami Y, Ikeda Y, Yonemitsu Y et al:Inhibition of choroidal neovascularization via brief subretinal exposure to a newly developed lentiviral vector pseudotyped with Sendai viral envelope proteins. Hum Gene Ther 21:199-209, 2010
20)Yafai Y, Yang XM, Niemeyer M et al:Anti-angiogenic effects of the receptor tyrosine kinase inhibitor, pazopanib, on choroidal neovascularization in rats. Eur J Pharmacol 666:12-18, 2011
, for age-related macular degeneration. Hum Gene Ther 23:980-991, 2012
22)Marneros AG, Keene DR, Hansen U et al:Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. Embo J 23:89-99, 2004
23)Barnstable CJ, Tombran-Tink J:Neuroprotective and antiangiogenic actions of PEDF in the eye:molecular targets and therapeutic potential. Prog Retin Eye Res 23:561-577, 2004
24)Campochiaro PA, Nguyen QD, Shah SM et al:Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration:results of a phase Ⅰ clinical trial. Hum Gene Ther 17:167-176, 2006
25)Ikeda Y, Yonemitsu Y, Miyazaki M et al:Stable retinal gene expression in nonhuman primates via subretinal injection of SIVagm-based lentiviral vectors. Hum Gene Ther 20:573-579, 2009