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文献詳細

雑誌文献

臨床眼科68巻1号

2014年01月発行

文献概要

特集 眼底疾患と悪性腫瘍

脈絡膜悪性黒色腫

著者: 鈴木茂伸1

所属機関: 1国立がん研究センター中央病院眼腫瘍科

ページ範囲:P.58 - P.65

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はじめに

 成人の眼内に生じる原発性悪性腫瘍で最も多いのは悪性黒色腫である。典型例は色素を伴う隆起病変で,ドーム状やマッシュルーム状の形状をとり,漿液性網膜剝離を伴うことが多い。通常は臨床診断に基づき治療方針を決定する。治療はレーザー,放射線治療,眼球摘出,局所切除などが行われる。転移を生じやすい腫瘍であり,常に生命予後を考えて診療にあたることが重要である。本稿では,疫学,診断,治療,予後について解説する。

参考文献

1)Singh AD, Topham A:Incidence of uveal melanoma in the United States:1973-1997. Ophthalmology 110:956-961, 2003
2)Hu DN, Yu GP, McCormick SA et al:Population-based incidence of uveal melanoma in various races and ethnic groups. Am J Ophthalmol 76:784-796, 1996
3)金子明博:1977年より3年間における日本の眼部悪性黒色腫の頻度について.日眼会誌 86:1042-1045,1982
4)Singh AD, Bergman L, Seregard S:Uveal melanoma:epidemiologic aspects. Ophthalmol Clin North Am 18:75-84, 2005
5)The Collaborative Ocular Melanoma Study Group:Accuracy of diagnosis of choroidal melanomas in the Collaborative Ocular Melanoma Study. COMS report no. 1. Arch Ophthalmol 108:1268-1273, 1990
6)Zimmerman LE, McLean IW, Foster WD:Does enucleation of the eye containing a malignant melanoma prevent or accelerate the dissemination of tumour cells. Br J Ophthalmol 62:420-425, 1978
7)Hawkins BS;Collaborative Ocular Melanoma Study Group:The Collaborative Ocular Melanoma Study(COMS)randomized trial of pre-enucleation radiation of large choroidal melanoma:Ⅳ. Ten-year mortality findings and prognostic factors. COMS report number 24. Am J Ophthalmol 138:936-951, 2004
8)Collaborative Ocular Melanoma Study Group:The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma:Ⅴ. Twelve-year mortality rates and prognostic factors:COMS report No. 28. Arch Ophthalmol 124:1684-1693, 2006
9)The Collaborative Ocular Melanoma Study Group:Factors predictive of growth and treatment of small choroidal melanoma:COMS Report No. 5. Arch Ophthalmol 115:1537-1544, 1997
10)Shields CL, Furuta M, Berman EL et al:Choroidal nevus transformation into melanoma:analysis of 2514 consecutive cases. Arch Ophthalmol 127:981-987, 2009
I]-iodoamphetamine. Jpn J Ophthalmol 55:148-154, 2011
12)Kato K, Kubota T, Ikeda M et al:Low efficacy of 18F-FDG PET for detection of uveal malignant melanoma compared with 123I-IMP SPECT. J Nucl Med 47:404-409, 2006
13)Tamura K, Yoshikawa K, Ishikawa H et al:Carbon-11-methionine PET imaging of choroidal melanoma and the time course after carbon ion beam radiotherapy. Anticancer Res 29:1507-1514, 2009
14)小森宏之・中面哲也・別府 透・他:GPC3(glypican-3).日本臨床 68(suppl 7):833-836,2010
15)Shields JA, Shields CL:Posterior uveal melanoma:diagnositic approaches. In Intraocular Tumors, pp 127-138, Lippincott Williams & Wilkins, Philaderphia, 2008
16)McCannel TA, Burgess BL, Rao NP et al:Identification of candidate tumor oncogenes by integrative molecular analysis of choroidal melanoma fine-needle aspiration biopsy specimens. Arch Ophthalmol 128:1170-1177, 2010
17)Malignant melanoma of the uvea. In:Edge SB, Byrd DR, Compton CC et al(eds):AJCC Cancer Staging Manual. 7th ed. pp 547-559, Springer, New York, 2010
18)Shields CL, Shields JA, Perez N et al.:Primary transpupillary thermotherapy for small choroidal melanoma in 256 consecutive cases:outcomes and limitations. Ophthalmology 109:225-234, 2002
19)Barbazetto IA, Lee TC, Rollins IS et al:Treatment of choroidal melanoma using photodynamic therapy. Am J Ophthalmol 135:898-899, 2003
20)Nag S, Quivey JM, Earle JD et al:The American Brachytherapy Society recommendations for brachytherapy of uveal melanomas. Int J Radiat Oncol Biol Phys 56:544-55, 2003
21)Damato B, Patel I, Campbell IR et al:Local tumor control after 106Ru brachytherapy of choroidal melanoma. Int J Radiat Oncol Biol Phys 63:385-391, 2005
22)Jampol LM, Moy CS, Murray TG et al:The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma:Ⅳ. Local treatment failure and enucleation in the first 5 years after brachytherapy. COMS report no. 19. Ophthalmology 109:2197-2206, 2002
23)Caujolle JP, Paoli V, Chamorey E et al:Local recurrence after uveal melanoma proton beam therapy:recurrence types and prognostic consequences. Int J Radiat Oncol Biol Phys 85:1218-1224, 2013
24)Castro JR, Char DH, Petti PL et al:15 years experience with helium ion radiotherapy for uveal melanoma. Int J Radiat Oncol Biol Phys 39:989-996, 1997
25)Char DH, Quivey JM, Castro JR et al.:Helium ions versus iodine 125 brachytherapy in the management of uveal melanoma. A prospective, randomized, dynamically balanced trial. Ophthalmology 100:1547-1554, 1993
26)Tsuji H, Ishikawa H, Yanagi T et al:Carbon-ion radiotherapy for locally advanced or unfavorably located choroidal melanoma:a Phase Ⅰ/Ⅱ dose-escalation study. Int J Radiat Oncol Biol Phys 67:857-862, 2007
27)Toyama S, Tsuji H, Mizoguchi N et al:Long-term results of carbon ion radiation therapy for locally advanced or unfavorably located choroidal melanoma:usefulness of CT-based 2-port orthogonal therapy for reducing the incidence of neovascular glaucoma. Int J Radiat Oncol Biol Phys 86:270-276, 2013
28)Modorati G, Miserocchi E, Galli L et al.:Gamma knife radiosurgery for uveal melanoma:12 years of experience. Br J Ophthalmol 93:40-44, 2009
29)Muller K, Nowak PJ, de Pan C et al.:Effectiveness of fractionated stereotactic radiotherapy for uveal melanoma. Int J Radiat Oncol Biol Phys 63:116-122, 2005
30)Damato B, Lecuona K:Conservation of eyes with choroidal melanoma by a multimodality approach to treatment:an audit of 1632 patients. Ophthalmology 111:977-983, 2004
31)Karkhaneh R, Chams H, Amoli FA el al:Long-term surgical outcome of posterior choroidal melanoma treated by endoresection. Retina 27:908-914, 2007
32)藤代貴志・小島孚允:局所切除術および眼球摘出術を行ったぶどう膜悪性黒色腫29例の長期予後.日眼会誌 112:847-854,2008
33)Flaherty KT, Puzanov I, Kim KB et al:Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 363:809-819, 2010
34)Diener-West M, Reynolds SM, Agugliaro DJ et al:Development of metastatic disease after enrollment in the COMS trials for treatment of choroidal melanoma:Collaborative Ocular Melanoma Study Group Report No. 26. Arch Ophthalmol 123:1639-1643, 2005
35)Wen JC, Sai V, Straatsma BR et al:Radiation-related cancer risk associated with surveillance imaging for metastasis from choroidal melanoma. JAMA Ophthalmol 131:56-61, 2013

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1308

印刷版ISSN:0370-5579

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