臨床眼科70巻2号

2016年02月発行

特集 緑内障治療の副作用・合併症対策総ざらい

点眼薬

著者： 井上賢治¹

所属機関： ¹井上眼科病院

ページ範囲：P.142 - P.150

はじめに

　緑内障治療では視野障害の進行を抑制するために眼圧を下降させる。点眼薬治療が効果と副作用の観点から第一選択である。緑内障点眼薬には現在8系統の点眼薬と，それらを組み合わせた配合点眼薬がある（図1，表1）。眼圧下降効果と副作用出現には個人差があり，多剤併用でも副作用が全く出現しない症例もあり，副作用の評価は難しい。

参考文献

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11）Inoue K, Shiokawa M, Wakakura M et al：Deepening of the upper eyelid sulcus caused by 5 types of prostaglandin analogs. J Glaucoma 22：626-631, 2013

12）Shah M, Lee G, Lefebvre DR et al：A cross-sectional survey of the association between bilateral topical prostaglandin analogue use and ocular adnexal features. PLoS One 8：e61638, 2013

13）Aptel F, Cucherat M, Denis P et al：Efficacy and tolerability of prostaglandin-timolol fixed combinations：a meta-analysis of randomized clinical trials. Eur J Ophthalmol 22：5-18, 2012

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16）Zimmerman TJ, Kooner KS, Kandarakis AS et al：Improving the therapeutic index of topically applied ocular drugs. Arch Ophthalmol 102：551-553, 1984