臨床眼科71巻12号

2017年11月発行

特集 視神経炎最前線

抗MOG抗体陽性視神経炎

著者： 毛塚剛司¹²

所属機関： ¹毛塚眼科医院 ²東京医科大学臨床医学系眼科学分野

ページ範囲：P.1676 - P.1681

はじめに

　特発性視神経炎は，大多数の症例でステロイド点滴療法に反応して寛解する。少数例ではあるが，ステロイド治療に抵抗性の場合もあれば，ステロイドを減量するとすぐに再発してしまう症例も存在する。特発性視神経炎は，自己免疫機序が原因となり発症に至ることが推察されており，特に特異抗体による視神経炎でその傾向が強いとされる。特異抗体陽性視神経炎では，ステロイド抵抗性である抗アクアポリン（aquaporin：AQP）4抗体陽性例に引き続き，最近，抗ミエリンオリゴデンドロサイトグリコプロテイン（myelin-oligodendrocyte-glycoprotein：MOG）に対する抗体が陽性となる視神経炎も発見された^1〜3）。本稿では，抗MOG抗体陽性視神経炎において推察される病態や視力予後などについて述べていきたいと思う。

参考文献

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