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臨床眼科76巻11号

2022年10月発行

文献概要

増刊号 最新臨床研究から探る眼科臨床のギモンQ&A 1 緑内障

交感神経α2受容体刺激薬には神経保護効果があると考えてよいですか?

著者: 横山悠1

所属機関: 1東北大学大学院医学系研究科神経感覚器病態学眼科学分野

ページ範囲:P.39 - P.43

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眼圧下降療法のようなエビデンスは確立されているとはいえませんが,いくつかの基礎研究,臨床研究で神経保護に関する有望な成果が報告されています.

参考文献

1)Krupin T et al;Low-Pressure Glaucoma Study Group:A randomized trial of brimonidine versus timolol in preserving visual function:results from the Low-Pressure Glaucoma Treatment Study. Am J Ophthalmol 151:671-681, 2011
2)Wheeler LA et al:Role of alpha-2 adrenergic receptors in neuroprotection and glaucoma. Surv Ophthalmol 45 Suppl 3:S290-S294, 2001
3)Matsuo T et al:Localization of alpha-2 adrenergic receptors in the human eye. Ophthalmic Res 24:213-219, 1992
4)Kalapesi FB et al:Human ganglion cells express the alpha-2 adrenergic receptor:relevance to neuroprotection. Br J Ophthalmol 89:758-763, 2005
5)Bylund DB et al:Characterization of alpha2 adrenergic receptor subtypes in human ocular tissue homogenates. Invest Ophthalmol Vis Sci 40:2299-2306, 1999
6)Takamura Y et al:Vitreous and aqueous concentrations of brimonidine following topical application of brimonidine tartrate 0.1% ophthalmic solution in humans. J Ocul Pharmacol Ther 31:282-285, 2015
7)Shinno K et al:The relationship of brimonidine concentration in vitreous body to the free concentration in retina/choroid following topical administration in pigmented rabbits. Curr Eye Res 42:748-753, 2017
8)Lambert WS et al:Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons. Mol Neurodegener 6:4, 2011
-Adrenergic modulation of the glutamate receptor and transporter function in a chronic ocular hypertension model. Eur J Pharmacol 765:274-283, 2015
10)Fujita Y et al:Brimonidine promotes axon growth after optic nerve injury through Erk phosphorylation. Cell Death Dis 4:e763, 2013
11)Dong CJ et al:Alpha2 adrenergic modulation of NMDA receptor function as a major mechanism of RGC protection in experimental glaucoma and retinal excitotoxicity. Invest Ophthalmol Vis Sci 49:4515-4522, 2008
12)Semba K et al:Brimonidine prevents neurodegeneration in a mouse model of normal tension glaucoma. Cell Death Dis 5:e1341, 2014
13)Lee D et al:Brimonidine blocks glutamate excitotoxicity-induced oxidative stress and preserves mitochondrial transcription factor a in ischemic retinal injury. PLoS One 7:e47098, 2012
14)Lai RK et al:Alpha-2 adrenoceptor agonist protects retinal function after acute retinal ischemic injury in the rat. Vis Neurosci 19:175-185, 2002
15)Mayor-Torroglosa S et al:Ischemia results 3 months later in altered ERG, degeneration of inner layers, and deafferented tectum:neuroprotection with brimonidine. Invest Ophthalmol Vis Sci 46:3825-3835, 2005
16)Yukita M et al:Brimonidine enhances the electrophysiological response of retinal ganglion cells through the Trk-MAPK/ERK and PI3K pathways in axotomized eyes. Curr Eye Res 42:125-133, 2017
17)Yokoyama Y et al:Effects of Brimonidine and Timolol on the Progression of Visual Field Defects in Open-angle Glaucoma:A Single-center Randomized Trial. J Glaucoma 28:575-583, 2019

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1308

印刷版ISSN:0370-5579

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