臨床眼科77巻1号

2023年01月発行

特集 日本の眼の難病—何がどこまでわかってきたのか？

急性帯状潜在性網膜外層症（AZOOR）

著者： 近藤峰生¹

所属機関： ¹三重大学医学部眼科学教室

ページ範囲：P.71 - P.77

●AZOORは，若年女性の片眼に発症し，急激な視力低下，視野欠損，光視症などを起こす網膜外層の疾患である。

●診断には，特徴的な症状に加えてOCTや多局所ERGが有用である。

●現時点ではエビデンスのある有効な治療法は存在しない。

参考文献

1）Gass JD：Acute zonal occult outer retinopathy. Donders Lecture：the Netherlands ophthalmological society, Maastricht, Holland, June 19, 1992. J Clin Neuroophthalmol 13：79-97, 1993

2）Gass JD, Agarwal A, Scott IU：Acute zonal occult outer retinopathy：a long-term follow-up study. Am J Ophthalmol 134：329-339, 2002

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5）Saito S, Saito W, Saito M et al：Acute zonal occult outer retinopathy in Japanese patients：clinical features, visual function, and factors affecting visual function. PLoS One 10：e0125133, 2015

6）Gass JD：Are acute zonal occult outer retinopathy and the white spot syndromes（AZOOR complex）specific autoimmune diseases? Am J Ophthalmol 135：380-381, 2003

7）Jampol LM, Becker KG：White spot syndromes of the retina：a hypothesis based on the common genetic hypothesis of autoimmune/inflammatory disease. Am J Ophthalmol 135：376-379, 2003

8）Pearlman RB, Golchet PR, Feldman MG et al：Increased prevalence of autoimmunity in patients with white spot syndromes and their family members. Arch Ophthalmol 127：869-874, 2009.

9）Spaide RF：Collateral damage in acute zonal occult outer retinopathy. Am J Ophthalmol 138：887-889, 2004

10）Saito A, Saito W, Furudate N et al：Indocyanine green angiography in a case of punctate inner choroidopathy associated with acute zonal occult outer retinopathy. Jpn J Ophthalmol 51：295-300, 2007

11）Fujiwara T, Imamura Y, Giovinazzo VJ et al：Fundus autofluorescence and optical coherence tomographic findings in acute zonal occult outer retinopathy. Retina 30：1206-1216, 2010

12）Ueno S, Kawano K, Ito Y et al：Near-infrared reflectance imaging in eyes with acute zonal occult outer retinopathy. Retina 35：1521-1530, 2015

13）Li D, Kishi S：Loss of photoreceptor outer segment in acute zonal occult outer retinopathy. Arch Ophthalmol 125：1194-1200, 2007

14）Spaide RF, Koizumi H, Freund KB：Photoreceptor outer segment abnormalities as a cause of blind spot enlargement in acute zonal occult outer retinopathy-complex diseases. Am J Ophthalmol 146：111-120, 2008

15）Matsui Y, Matsubara H, Ueno S et al：Changes in outer retinal microstructures during six month period in eyes with acute zonal occult outer retinopathy-complex. PLoS One 9：e110592, 2014

16）Tsunoda K, Fujinami K, Miyake Y et al：Selective abnormality of cone outer segment tip line in acute zonal occult outer retinopathy as observed by spectral-domain optical coherence tomography. Arch Ophthalmol 129：1099-1101, 2011

17）Francis PJ, Marinescu A, Fitzke FW et al：Acute zonal occult outer retinopathy：towards a set of diagnostic criteria. Br J Ophthalmol 89：70-73, 2005

18）Arai M, Nao-i N, Sawada A et al：Multifocal electroretinogram indicates visual field loss in acute zonal occult outer retinopathy. Am J Ophthalmol 126：466-469, 1998

19）Jampol LM, Wiredu A：MEWDS, MFC, PIC, AMN, AIBSE, and AZOOR：one disease or many? Retina 15：373-378, 1995

20）Gass JD, Stern C：Acute annular outer retinopathy as a variant of acute zonal occult outer retinopathy. Am J Ophthalmol 119：330-334, 1995

21）近藤峰生・飯田知弘・園田康平・他：急性帯状潜在性網膜外層症（AZOOR）の診断ガイドライン 日眼会誌123：443-449，2019