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文献詳細

雑誌文献

臨床眼科77巻2号

2023年02月発行

文献概要

特集 視神経炎診療のブレークスルー—病態理解から新規治療まで 【治療法の特性・副作用】

抗補体蛋白抗体製剤・抗CD19(CD20)抗体製剤

著者: 澤村裕正1

所属機関: 1東京大学医学部眼科学教室

ページ範囲:P.210 - P.215

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●抗アクアポリン4抗体陽性視神経炎の病態の理解が進んでいる。

●抗アクアポリン4抗体陽性視神経炎では再発予防も重要である。

●再発予防として,複数の分子標的薬が承認されてきている。

参考文献

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6)Rensel M, Zabeti A, Mealy MA et al:Long-term efficacy and safety of inebilizumab in neuromyelitis optica spectrum disorder:Analysis of aquaporin-4—immunoglobulin G—seropositive participants taking inebilizumab for≥4 years in the N-MOmentum trial. Mult Scler 28:925-932, 2022
7)Tahara M, Oeda T, Okada K et al:Safety and efficacy of rituximab in neuromyelitis optica spectrum disorders(RIN-1 study):a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol 19:298-306, 2020
8)Pittock SJ, Berthele A, Fujihara K et al:Eculizumab in aquaporin-4—positive neuromyelitis optica spectrum disorder. N Engl J Med 381:614-625, 2019
9)Wingerchuk DM, Fujihara K, Palace J et al:Long-term safety and efficacy of eculizumab in aquaporin-4 IgG-positive NMOSD. Ann Neurol 89:1088-1098, 2021
10)Lee DSW, Rojas OL, Gommerman JL:B cell depletion therapies in autoimmune disease:advances and mechanistic insights. Nat Rev Drug Discov 20:179-199, 2021
11)Papadopoulos MC, Bennett JL, Verkman AS:Treatment of neuromyelitis optica:state-of-the-art and emerging therapies. Nat Rev Neurol 10:493-506, 2014
12)Fujihara K, Bennett JL, de Seze J et al:Interleukin-6 in neuromyelitis optica spectrum disorder pathophysiology. Neurol Neuroimmunol Neuroinflamm 7:e841, 2020
13)Takeshita Y, Fujikawa S, Serizawa K et al:New BBB model reveals that IL-6 blockade suppressed the BBB disorder, preventing onset of NMOSD. Neurol Neuroimmunol Neuroinflamm 8:e1076, 2021
14)Pittock SJ, Zekeridou A, Weinshenker BG:Hope for patients with neuromyelitis optica spectrum disorders- from mechanisms to trials. Nat Rev Neurol 17:759-773, 2021

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1308

印刷版ISSN:0370-5579

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